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Protein

Type 2 DNA topoisomerase 6 subunit A

Gene

top6A

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Relaxes both positive and negative superturns and exhibits a strong decatenase activity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081NucleophileUniRule annotation
Metal bindingi202 – 2021MagnesiumUniRule annotation
Metal bindingi254 – 2541MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

ATP-binding, DNA-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 DNA topoisomerase 6 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Type II DNA topoisomerase VI subunit AUniRule annotation
Gene namesi
Name:top6AUniRule annotation
Ordered Locus Names:PYRAB05950
ORF Names:PAB2411
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Type 2 DNA topoisomerase 6 subunit APRO_0000145452Add
BLAST

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two Top6A and two Top6B chains.UniRule annotation

Protein-protein interaction databases

IntActiQ9V134. 1 interaction.
MINTiMINT-7906156.
STRINGi272844.PAB2411.

Structurei

3D structure databases

ProteinModelPortaliQ9V134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TOP6A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04143. Archaea.
COG1697. LUCA.
HOGENOMiHOG000225930.
KOiK03166.
OMAiWEEQIEL.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A. 1 hit.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKRQKPKE KFSYDPQKVL KKLEDLAWKI LEEVKSGKNP YFDVPTRGLN
60 70 80 90 100
NVYFDEEARL IKLGDKLSRR YFLNVAHARK FTQTLILMAY IKRLVSEGKH
110 120 130 140 150
ASLREAYYAN KHTIPGTREN TFEDQSESDP IIEDLERMLG VLREEMHITA
160 170 180 190 200
DRRGYIYGDI VIKDGEDEFN ASKLGTGGWA VPGTVEHIQF PEVNVDYVLV
210 220 230 240 250
VETAAMADRL IEEKYPKKEN CLIVATQGQA SRGVRRLIHR LHYEEGLPII
260 270 280 290 300
VFTDGDPYGW YIYSTIKQGS INLAYLSEKL ATPDAKFVGM TMDDIKEYNL
310 320 330 340 350
EHVTEKLKGI PPDKKGGPTG DYKRLIEELN YPWFQNKEWQ RQLKLALKWG
360 370 380
VRIEQQALAN KSLEFVAKEY LPEKIREGKL LP
Length:382
Mass (Da):44,188
Last modified:May 1, 2000 - v1
Checksum:i6462F819FDEBD6BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49517.1.
HE613800 Genomic DNA. Translation: CCE69987.1.
PIRiF75179.
RefSeqiWP_010867719.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49517; CAB49517; PAB2411.
GeneIDi1495500.
KEGGipab:PAB2411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49517.1.
HE613800 Genomic DNA. Translation: CCE69987.1.
PIRiF75179.
RefSeqiWP_010867719.1. NC_000868.1.

3D structure databases

ProteinModelPortaliQ9V134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9V134. 1 interaction.
MINTiMINT-7906156.
STRINGi272844.PAB2411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49517; CAB49517; PAB2411.
GeneIDi1495500.
KEGGipab:PAB2411.

Phylogenomic databases

eggNOGiarCOG04143. Archaea.
COG1697. LUCA.
HOGENOMiHOG000225930.
KOiK03166.
OMAiWEEQIEL.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A. 1 hit.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTOP6A_PYRAB
AccessioniPrimary (citable) accession number: Q9V134
Secondary accession number(s): G8ZJ60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.