Q9V113 (RPOA2_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit A''
EC=2.7.7.6

Gene names

Name:	rpoA2
Ordered Locus Names:	PYRAB06160
ORF Names:	PAB0425

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_00411
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_00411
Sequence similarities	Belongs to the RNA polymerase beta' chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	DNA-directed RNA polymerase subunit A'' HAMAP MF_00411		PRO_0000074020

Sequences

	Sequence		Length	Mass (Da)
	Q9V113 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E459658EAE9C15CB	FASTA	397	44,595
	10 20 30 40 50 60 MVSSSTIKSL IEKKGKDLPE SVKQELYEKL IKYNEKYKLT KAEVETIIDE VVKEYERALV 70 80 90 100 110 120 EPGEAVGTVA AQSIGEPSTQ MTLNTFHYAG VAEINVTLGL PRIIEIVDAR KNPSTPMMTV 130 140 150 160 170 180 YLDEEHRYDR EKAEEVARRI EGTTLENLAR TTTLDLINME FIVEIDPERL EKSGLTMEKV 190 200 210 220 230 240 LKKLQSSFKS AEFEMEGYTL IVRPKKFEKI SDLRRLAEKV KKHRLKGLSG VGKTIVRKEG 250 260 270 280 290 300 DEYVIYTEGS NFKQVLKVPG VDPTRTKTNN IHEIAEVLGI EAARNAIIEE IMNTMREQGL 310 320 330 340 350 360 EVDIRHIMLV ADIMTLDGVV RPIGRHGVVG EKASVLARAA FEITVQHLFE AAERGEVDNL 370 380 390 SGVIENVLIG QPVPVGTGMV KLTMKLPLRP QKEKEEV

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49538.1.
PIR	C75182.
RefSeq	NP_126307.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V113.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002783; EBPYRP00000002714; EBPYRG00000002783.
GeneID	1495521.
GenomeReviews	Gene locus PYRAB06160 in contig AL096836_GR.
KEGG	pab:PAB0425.
NMPDR	fig|272844.1.peg.645.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023271.
HOGENOM	HBG297327.
OMA	RPIGRHG.
ProtClustDB	PRK04309.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0425-MONOMER.
Family and domain databases
HAMAP	MF_00411. RNApol_arch_A. [Tree]
InterPro	IPR012757. DNA-dir_RpoA2. IPR007081. RNA_pol_Rpb1_5. [Graphical view]
KO	K03042.
Pfam	PF04998. RNA_pol_Rpb1_5. 1 hit. [Graphical view]
TIGRFAMs	TIGR02389. RNA_pol_rpoA2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPOA2_PYRAB

Accession

Primary (citable) accession number: Q9V113

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program