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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:PYRAB06880
ORF Names:PAB0469
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625Arginine--tRNA ligasePRO_0000151650Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0469.

Structurei

3D structure databases

ProteinModelPortaliQ9V0V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi128 – 13811"HIGH" regionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiDFQGNTG.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V0V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRVKEGAR EKIIKVIESL APGWKGEIEF KDTPSPELGD FGTPVAFKLA
60 70 80 90 100
RVMKKPPFQI AELIVEELKK ELPEGIREVR AINGYVNFFV DYGYLARQLI
110 120 130 140 150
VEVLEKGDRF GSSDIGRGKK VIVEHTSVNP TKPLHMGHAR NAILGDSMAR
160 170 180 190 200
ILRFLGYEVE VQNYIDDLGI QFAQVYWGYL KLREKFEKIM KELKEKGIKE
210 220 230 240 250
DPIDHVLGLL YVEVNRVLEE NPEIEAEIRD IMKKLESGEL NGRELAESVV
260 270 280 290 300
RAQMVTTYRL GIKYDLLVWE SDIVSRKLFE IAVKLLERNE NFYTPNEGKY
310 320 330 340 350
KGAFVMDLSK LFPDMKNPYL VLRRSDGTAT YTGKDIAYHL WKFGKIDVDL
360 370 380 390 400
LYKPWDEHTW TTAPDGESVK GKFGGADIVI NVIGAEQRHP QMAIKHALKL
410 420 430 440 450
LGFEDAAENL HHLAYEHVER PEGKFSGRKG TWVGFTVDEV INEAIKRARE
460 470 480 490 500
LIEEKSPGLS DEEKEEIAEK VGVGAIRYNM VKYSPDKKII FRWEDVLNFE
510 520 530 540 550
GESAPYIQYA HARCSSILRK AGNPEWEALL KEANFKELTE RERELIILLS
560 570 580 590 600
KFPEVVEQAG RDVKPHLIAW YANELASLFN KFYMDHPVIK AEKGIREARL
610 620
LLVMAVRQVL RNSLWLLGIE APDRM
Length:625
Mass (Da):71,691
Last modified:May 1, 2000 - v1
Checksum:iF1B1E7D79AFEC891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA. Translation: CAB49601.1.
HE613800 Genomic DNA. Translation: CCE70077.1.
PIRiH75110.
RefSeqiNP_126370.1. NC_000868.1.
WP_010867806.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49601; CAB49601; PAB0469.
GeneIDi1495590.
KEGGipab:PAB0469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA. Translation: CAB49601.1.
HE613800 Genomic DNA. Translation: CCE70077.1.
PIRiH75110.
RefSeqiNP_126370.1. NC_000868.1.
WP_010867806.1. NC_000868.1.

3D structure databases

ProteinModelPortaliQ9V0V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49601; CAB49601; PAB0469.
GeneIDi1495590.
KEGGipab:PAB0469.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiDFQGNTG.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiSYR_PYRAB
AccessioniPrimary (citable) accession number: Q9V0V2
Secondary accession number(s): G8ZJF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.