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Q9V0V2 (SYR_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:PYRAB06880
ORF Names:PAB0469
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 625625Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151650

Regions

Motif128 – 13811"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q9V0V2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F1B1E7D79AFEC891

FASTA62571,691
        10         20         30         40         50         60 
MLSRVKEGAR EKIIKVIESL APGWKGEIEF KDTPSPELGD FGTPVAFKLA RVMKKPPFQI 

        70         80         90        100        110        120 
AELIVEELKK ELPEGIREVR AINGYVNFFV DYGYLARQLI VEVLEKGDRF GSSDIGRGKK 

       130        140        150        160        170        180 
VIVEHTSVNP TKPLHMGHAR NAILGDSMAR ILRFLGYEVE VQNYIDDLGI QFAQVYWGYL 

       190        200        210        220        230        240 
KLREKFEKIM KELKEKGIKE DPIDHVLGLL YVEVNRVLEE NPEIEAEIRD IMKKLESGEL 

       250        260        270        280        290        300 
NGRELAESVV RAQMVTTYRL GIKYDLLVWE SDIVSRKLFE IAVKLLERNE NFYTPNEGKY 

       310        320        330        340        350        360 
KGAFVMDLSK LFPDMKNPYL VLRRSDGTAT YTGKDIAYHL WKFGKIDVDL LYKPWDEHTW 

       370        380        390        400        410        420 
TTAPDGESVK GKFGGADIVI NVIGAEQRHP QMAIKHALKL LGFEDAAENL HHLAYEHVER 

       430        440        450        460        470        480 
PEGKFSGRKG TWVGFTVDEV INEAIKRARE LIEEKSPGLS DEEKEEIAEK VGVGAIRYNM 

       490        500        510        520        530        540 
VKYSPDKKII FRWEDVLNFE GESAPYIQYA HARCSSILRK AGNPEWEALL KEANFKELTE 

       550        560        570        580        590        600 
RERELIILLS KFPEVVEQAG RDVKPHLIAW YANELASLFN KFYMDHPVIK AEKGIREARL 

       610        620 
LLVMAVRQVL RNSLWLLGIE APDRM 

« Hide

References

« Hide 'large scale' references
[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.
[2]"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
Gao J., Wang J.
Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: GE5 / Orsay.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ248285 Genomic DNA. Translation: CAB49601.1.
HE613800 Genomic DNA. Translation: CCE70077.1.
PIRH75110.
RefSeqNP_126370.1. NC_000868.1.

3D structure databases

ProteinModelPortalQ9V0V2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272844.PAB0469.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB49601; CAB49601; PAB0469.
GeneID1495590.
KEGGpab:PAB0469.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMANPNGPLH.
ProtClustDBPRK01611.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_PYRAB
AccessionPrimary (citable) accession number: Q9V0V2
Secondary accession number(s): G8ZJF0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries