ID   Q9V0Q7_PYRAB            Unreviewed;       454 AA.
AC   Q9V0Q7;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   SubName: Full=4-aminobutyrate aminotransferase {ECO:0000313|EMBL:CCE70128.1};
DE   SubName: Full=Pyridoxal phosphate-dependent aminotransferase {ECO:0000313|EMBL:CAB49646.1};
GN   Name=gabT {ECO:0000313|EMBL:CAB49646.1};
GN   ORFNames=PAB0501 {ECO:0000313|EMBL:CAB49646.1};
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844 {ECO:0000313|EMBL:CAB49646.1, ECO:0000313|Proteomes:UP000000810};
RN   [1] {ECO:0000313|EMBL:CAB49646.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Orsay {ECO:0000313|EMBL:CAB49646.1};
RA   Genoscope;
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAB49646.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Orsay {ECO:0000313|EMBL:CAB49646.1};
RX   PubMed=10736225; DOI=10.1006/jmbi.2000.3593;
RA   Gaspin C., Cavaille J., Erauso G.;
RT   "Archaeal homologs of eukaryotic methylation guide small nucleolar RNAs:
RT   lessons from the Pyrococcus genomes.";
RL   J. Mol. Biol. 297:895-906(2000).
RN   [3] {ECO:0000313|EMBL:CAB49646.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Orsay {ECO:0000313|EMBL:CAB49646.1};
RX   PubMed=11381026; DOI=10.1101/gr.GR1653R;
RA   Lecompte O., Ripp R., Puzos-Barbe V., Duprat S., Heilig R., Dietrich J.,
RA   Thierry J.C., Poch O.;
RT   "Genome evolution at the genus level: comparison of three complete genomes
RT   of hyperthermophilic archaea.";
RL   Genome Res. 11:981-993(2001).
RN   [4] {ECO:0000313|EMBL:CAB49646.1, ECO:0000313|Proteomes:UP000000810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay {ECO:0000313|Proteomes:UP000000810}, and Orsay
RC   {ECO:0000313|EMBL:CAB49646.1};
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G., Barbe V., Flament D., Galperin M., Heilig R., Ripp R.,
RA   Lecompte O., Prieur D., Poch O., Quellerou J., Thierry J.C.,
RA   Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [5] {ECO:0000313|EMBL:CCE70128.1, ECO:0000313|Proteomes:UP000009139}
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 {ECO:0000313|EMBL:CCE70128.1}, and GE5 / Orsay
RC   {ECO:0000313|Proteomes:UP000009139};
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|RuleBase:RU003560}.
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DR   EMBL; AJ248285; CAB49646.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70128.1; -; Genomic_DNA.
DR   PIR; E75116; E75116.
DR   RefSeq; WP_010867854.1; NC_000868.1.
DR   AlphaFoldDB; Q9V0Q7; -.
DR   STRING; 272844.PAB0501; -.
DR   GeneID; 1495641; -.
DR   KEGG; pab:PAB0501; -.
DR   PATRIC; fig|272844.11.peg.772; -.
DR   eggNOG; arCOG00915; Archaea.
DR   HOGENOM; CLU_016922_10_0_2; -.
DR   OrthoDB; 6534at2157; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR049704; Aminotrans_3_PPA_site.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1.
DR   PANTHER; PTHR11986:SF58; LEUCINE_METHIONINE RACEMASE; 1.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:CAB49646.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU003560}; Transferase {ECO:0000313|EMBL:CCE70128.1}.
SQ   SEQUENCE   454 AA;  50667 MW;  A1B435EF65185898 CRC64;
     MELKPNVKEI PGPKARKVIE EHHKYMATTT NDPNEYFLVI EKAEGVYWID VDGNVILDFS
     SGIGVMNVGL RNPKVIEAIK KQLDLVLHAA GTDYYNPYQV ELAKKLIEIA PGDMERKVFL
     SNSGTEANEA ALKIAKWSTN RKMFIAFIGA FHGRTHGTMS LTASKPVHRS RMFPTMPGVE
     HVPYPNPYRN PWGIDGYENP DELINRVIEY IEDYLFEHYV PAEEVAGIFF EPIQGEGGYV
     VPPKNFFKEL KKLADKHGIL LIDDEVQMGM GRTGRMWAIE HFDVVPDIIT VAKALGGGIP
     IGATIFRADL DFGVSGVHSN TFGGNAVAAA AALAVIEELQ NGLIENAQKL EPLFRERLEE
     MKEKYEIIGD VRGLGLAWGV EFVKDRKTKE YATKERNEIV VEALKRGLAL LGCGKSAIRL
     IPPLIISEEE AKIGLDIFEE AIKVVSERHG YKIH
//