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Q9V0N0

- PANE_PYRAB

UniProt

Q9V0N0 - PANE_PYRAB

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Protein
Putative 2-dehydropantoate 2-reductase
Gene
apbA, PYRAB07590, PAB0512
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991NADP; via amide nitrogen By similarity
Binding sitei99 – 991Substrate By similarity
Active sitei179 – 1791Proton donor By similarity
Binding sitei183 – 1831Substrate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei249 – 2491Substrate By similarity
Binding sitei261 – 2611NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:apbA
Ordered Locus Names:PYRAB07590
ORF Names:PAB0512
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Putative 2-dehydropantoate 2-reductase
PRO_0000157325Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0512.

Structurei

3D structure databases

ProteinModelPortaliQ9V0N0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiSQCHILL.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V0N0-1 [UniParc]FASTAAdd to Basket

« Hide

MKIYILGAGA IGSLFGGLLA NAGEDVLLIG RDPHVSAINE KGLKIVGIKD    50
LNVKVEATTR VPEEKPDLIV LATKSYSTIE ALKSARHIVK GSWVLSIQNG 100
IGNEDKIIEF GGKAIGGITT NGAMVEAPGV IKWTGKGVTI IGLYPQGKEK 150
FIEKVADVFN SADIETHVSE NIISWIWAKA IVNSAINPIG TLLEVKNKVI 200
RENDFLLSMA MEVVKEGCRV ALQNGIEFDV PPMDLFFQTL EQTRENYNSM 250
LQDIWRGKKT EVDYINGKIV EYAKAVNLEA PMNLLLWGLI KGKEALEGKK 300
Length:300
Mass (Da):32,773
Last modified:May 1, 2000 - v1
Checksum:iF559625B73F691DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248285 Genomic DNA. Translation: CAB49673.1.
HE613800 Genomic DNA. Translation: CCE70155.1.
PIRiH75119.
RefSeqiNP_126442.1. NC_000868.1.
WP_010867881.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49673; CAB49673; PAB0512.
GeneIDi1496099.
KEGGipab:PAB0512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248285 Genomic DNA. Translation: CAB49673.1 .
HE613800 Genomic DNA. Translation: CCE70155.1 .
PIRi H75119.
RefSeqi NP_126442.1. NC_000868.1.
WP_010867881.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9V0N0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB0512.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB49673 ; CAB49673 ; PAB0512 .
GeneIDi 1496099.
KEGGi pab:PAB0512.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi SQCHILL.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiPANE_PYRAB
AccessioniPrimary (citable) accession number: Q9V0N0
Secondary accession number(s): G8ZGW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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