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Q9V0N0

- PANE_PYRAB

UniProt

Q9V0N0 - PANE_PYRAB

Protein

Putative 2-dehydropantoate 2-reductase

Gene

apbA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991NADP; via amide nitrogenBy similarity
    Binding sitei99 – 991SubstrateBy similarity
    Active sitei179 – 1791Proton donorBy similarity
    Binding sitei183 – 1831SubstrateBy similarity
    Binding sitei187 – 1871SubstrateBy similarity
    Binding sitei249 – 2491SubstrateBy similarity
    Binding sitei261 – 2611NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:apbA
    Ordered Locus Names:PYRAB07590
    ORF Names:PAB0512
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Putative 2-dehydropantoate 2-reductasePRO_0000157325Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272844.PAB0512.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V0N0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiSQCHILL.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9V0N0-1 [UniParc]FASTAAdd to Basket

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    MKIYILGAGA IGSLFGGLLA NAGEDVLLIG RDPHVSAINE KGLKIVGIKD    50
    LNVKVEATTR VPEEKPDLIV LATKSYSTIE ALKSARHIVK GSWVLSIQNG 100
    IGNEDKIIEF GGKAIGGITT NGAMVEAPGV IKWTGKGVTI IGLYPQGKEK 150
    FIEKVADVFN SADIETHVSE NIISWIWAKA IVNSAINPIG TLLEVKNKVI 200
    RENDFLLSMA MEVVKEGCRV ALQNGIEFDV PPMDLFFQTL EQTRENYNSM 250
    LQDIWRGKKT EVDYINGKIV EYAKAVNLEA PMNLLLWGLI KGKEALEGKK 300
    Length:300
    Mass (Da):32,773
    Last modified:May 1, 2000 - v1
    Checksum:iF559625B73F691DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248285 Genomic DNA. Translation: CAB49673.1.
    HE613800 Genomic DNA. Translation: CCE70155.1.
    PIRiH75119.
    RefSeqiNP_126442.1. NC_000868.1.
    WP_010867881.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB49673; CAB49673; PAB0512.
    GeneIDi1496099.
    KEGGipab:PAB0512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248285 Genomic DNA. Translation: CAB49673.1 .
    HE613800 Genomic DNA. Translation: CCE70155.1 .
    PIRi H75119.
    RefSeqi NP_126442.1. NC_000868.1.
    WP_010867881.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9V0N0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB0512.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB49673 ; CAB49673 ; PAB0512 .
    GeneIDi 1496099.
    KEGGi pab:PAB0512.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi SQCHILL.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiPANE_PYRAB
    AccessioniPrimary (citable) accession number: Q9V0N0
    Secondary accession number(s): G8ZGW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3