Q9V0N0 (PANE_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 2-dehydropantoate 2-reductase
EC=1.1.1.169

Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR

Gene names

Ordered Locus Names:	PYRAB07590
ORF Names:	PAB0512

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.
Catalytic activity	(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the ketopantoate reductase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-dehydropantoate 2-reductase activity Inferred from electronic annotation. Source: EC NADP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Putative 2-dehydropantoate 2-reductase		PRO_0000157325
Regions
	Nucleotide binding	7 – 12	6	NADP By similarity
Sites
	Active site	179	1	Proton donor By similarity
	Binding site	99	1	NADP; via amide nitrogen By similarity
	Binding site	99	1	Substrate By similarity
	Binding site	183	1	Substrate By similarity
	Binding site	187	1	Substrate By similarity
	Binding site	249	1	Substrate By similarity
	Binding site	261	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V0N0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F559625B73F691DC	FASTA	300	32,773
	10 20 30 40 50 60 MKIYILGAGA IGSLFGGLLA NAGEDVLLIG RDPHVSAINE KGLKIVGIKD LNVKVEATTR 70 80 90 100 110 120 VPEEKPDLIV LATKSYSTIE ALKSARHIVK GSWVLSIQNG IGNEDKIIEF GGKAIGGITT 130 140 150 160 170 180 NGAMVEAPGV IKWTGKGVTI IGLYPQGKEK FIEKVADVFN SADIETHVSE NIISWIWAKA 190 200 210 220 230 240 IVNSAINPIG TLLEVKNKVI RENDFLLSMA MEVVKEGCRV ALQNGIEFDV PPMDLFFQTL 250 260 270 280 290 300 EQTRENYNSM LQDIWRGKKT EVDYINGKIV EYAKAVNLEA PMNLLLWGLI KGKEALEGKK

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248285 Genomic DNA. Translation: CAB49673.1.
PIR	H75119.
RefSeq	NP_126442.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V0N0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003299; EBPYRP00000003230; EBPYRG00000003299.
GeneID	1496099.
GenomeReviews	Gene locus PYRAB07590 in contig AL096836_GR.
KEGG	pab:PAB0512.
NMPDR	fig|272844.1.peg.792.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023359.
HOGENOM	HBG668370.
OMA	ITTNGAM.
PhylomeDB	Q9V0N0.
ProtClustDB	PRK06522.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0512-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR003710. ApbA. IPR013752. ApbA_C. IPR013332. ApbA_N. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00077.
Pfam	PF02558. ApbA. 1 hit. PF08546. ApbA_C. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00745. ApbA_panE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANE_PYRAB

Accession

Primary (citable) accession number: Q9V0N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program