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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341Aspartate; via amide nitrogenBy similarity
Binding sitei171 – 1711AspartateBy similarity
Binding sitei362 – 3621AspartateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:PYRAB07770
ORF Names:PAB0525
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Aspartate aminotransferasePRO_0000123860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272844.PAB0525.

Structurei

3D structure databases

ProteinModelPortaliQ9V0L2.
SMRiQ9V0L2. Positions 2-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01130. Archaea.
COG0436. LUCA.
HOGENOMiHOG000223062.
KOiK10907.
OMAiLIPEPCF.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V0L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSDRLDLV NPSEIRKLFD IAAGMKDVIS LGIGEPDFDT PQHIKEYAKE
60 70 80 90 100
ALDMGLTHYG PNIGLPELRE AIAEKLKKQN NIEADPNKEI MVLVGANQAF
110 120 130 140 150
LMGLSAFLKD GEEVLIPTPA FVSYAPAVIL AGGKPVEVPT YEENEFRLNV
160 170 180 190 200
DELKKYVTEK TKALIINSPC NPTGSVLKKK DLEEIADFAV EHDLIVISDE
210 220 230 240 250
VYEHFIYDDV KHYSIASLDG MFERTITVNG FSKTFAMTGW RLGFVAAPSW
260 270 280 290 300
IIEKMVKFQM YNATCPVTFI QYAAAKALRD ERSWKAVEEM RKEYDRRRKL
310 320 330 340 350
VWKRLNEMGL PTVKPKGAFY IFPRIKDTGL TSKEFSELML MEAKVAVVPG
360 370 380
SAFGKAGEGY VRISYATAYE KLEEAMDRME KVLREKKLT
Length:389
Mass (Da):43,923
Last modified:May 1, 2000 - v1
Checksum:iAC811F1A171A513C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA. Translation: CAB49691.1.
HE613800 Genomic DNA. Translation: CCE70174.1.
PIRiB75122.
RefSeqiWP_010867899.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49691; CAB49691; PAB0525.
GeneIDi1496118.
KEGGipab:PAB0525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA. Translation: CAB49691.1.
HE613800 Genomic DNA. Translation: CCE70174.1.
PIRiB75122.
RefSeqiWP_010867899.1. NC_000868.1.

3D structure databases

ProteinModelPortaliQ9V0L2.
SMRiQ9V0L2. Positions 2-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49691; CAB49691; PAB0525.
GeneIDi1496118.
KEGGipab:PAB0525.

Phylogenomic databases

eggNOGiarCOG01130. Archaea.
COG0436. LUCA.
HOGENOMiHOG000223062.
KOiK10907.
OMAiLIPEPCF.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiAAT_PYRAB
AccessioniPrimary (citable) accession number: Q9V0L2
Secondary accession number(s): G8ZGX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.