Reviewed, UniProtKB/Swiss-Prot Q9V0L2 (AAT_PYRAB)

Names and origin

Protein names

Recommended name:
    Aspartate aminotransferase
      Short name=AspAT
    EC=2.6.1.1
Alternative name(s):
    Transaminase A

Gene names

Name:	aspC
Ordered Locus Names:	PYRAB07770
ORF Names:	PAB0525

Organism

Pyrococcus abyssi [Complete proteome] [HAMAP]

Taxonomic identifier

29292 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Aspartate aminotransferase		PRO_0000123860
Amino acid modifications
	Modified residue	233	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V0L2-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: AC811F1A171A513C	FASTA	389	43,923
	10 20 30 40 50 60 MAMSDRLDLV NPSEIRKLFD IAAGMKDVIS LGIGEPDFDT PQHIKEYAKE ALDMGLTHYG 70 80 90 100 110 120 PNIGLPELRE AIAEKLKKQN NIEADPNKEI MVLVGANQAF LMGLSAFLKD GEEVLIPTPA 130 140 150 160 170 180 FVSYAPAVIL AGGKPVEVPT YEENEFRLNV DELKKYVTEK TKALIINSPC NPTGSVLKKK 190 200 210 220 230 240 DLEEIADFAV EHDLIVISDE VYEHFIYDDV KHYSIASLDG MFERTITVNG FSKTFAMTGW 250 260 270 280 290 300 RLGFVAAPSW IIEKMVKFQM YNATCPVTFI QYAAAKALRD ERSWKAVEEM RKEYDRRRKL 310 320 330 340 350 360 VWKRLNEMGL PTVKPKGAFY IFPRIKDTGL TSKEFSELML MEAKVAVVPG SAFGKAGEGY 370 380 VRISYATAYE KLEEAMDRME KVLREKKLT

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ248285 Genomic DNA. Translation: CAB49691.1.
PIR	B75122.
RefSeq	NP_126460.1.
3D structure databases
HSSP	HSSP built from PDB template 1GD9 based on UniProtKB O59096.
SMR	Q9V0L2. Positions 2-388.
ModBase	Search...
Genome annotation databases
GeneID	1496118.
GenomeReviews	Gene locus PYRAB07770 in contig AL096836_GR.
KEGG	pab:PAB0525.
NMPDR	fig|272844.1.peg.811.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9V0L2.
OMA	KTHYAPS.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0525-MON.
BRENDA	2.6.1.1. 262861.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAT_PYRAB

Accession

Primary (citable) accession number: Q9V0L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)