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Q9V0D5

- MDH_PYRAB

UniProt

Q9V0D5 - MDH_PYRAB

Protein

Malate dehydrogenase

Gene

mdh

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    Ordered Locus Names:PYRAB08550
    ORF Names:PAB1791
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Malate dehydrogenasePRO_0000083828Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi272844.PAB1791.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V0D5.
    SMRiQ9V0D5. Positions 1-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH2/MDH2 oxidoreductase family.Curated

    Phylogenomic databases

    eggNOGiCOG2055.
    HOGENOMiHOG000173270.
    OMAiHFFMAID.

    Family and domain databases

    InterProiIPR003767. Malate/L-lactate_DH.
    [Graphical view]
    PANTHERiPTHR11091. PTHR11091. 1 hit.
    PfamiPF02615. Ldh_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF89733. SSF89733. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9V0D5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFEKGYVDEN YVRIPKDELF SFVVRVLTKL GTPEEDAKIV ADNLIMADLR    50
    GIESHGVQRL KRYVDGILSG GINLHPRIKI IREGPSYALL DGDEGFGQVV 100
    GYKAMKLAIE KARKTGIGIV AVRNSNHYGI AGYYALMAAE EGMIGISMTN 150
    SRPLVAPTGG VERILGTNPI ALAAPTKGKP FLLDMATSVV PIGKLEVYRR 200
    KGEEIPEGWA INSKGEITRS VEEVFNGGSL LPLGGFGELL GGHKGYGLSL 250
    MVDILSGILS GGTWSKHVKN TNEKNSNVCH FFMAINIEHF TPLEEFKGRM 300
    SEMINEIKNS RKHPDFERIW IHGEKGFLTM ETRLKLGIPI YKKVLDELNE 350
    IARRVGVKGL EV 362
    Length:362
    Mass (Da):39,907
    Last modified:May 1, 2000 - v1
    Checksum:i1E15C2E9E6BA5012
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248285 Genomic DNA. Translation: CAB49769.1.
    HE613800 Genomic DNA. Translation: CCE70260.1.
    PIRiH75131.
    RefSeqiNP_126538.1. NC_000868.1.
    WP_010867978.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB49769; CAB49769; PAB1791.
    GeneIDi1496204.
    KEGGipab:PAB1791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248285 Genomic DNA. Translation: CAB49769.1 .
    HE613800 Genomic DNA. Translation: CCE70260.1 .
    PIRi H75131.
    RefSeqi NP_126538.1. NC_000868.1.
    WP_010867978.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9V0D5.
    SMRi Q9V0D5. Positions 1-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB1791.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB49769 ; CAB49769 ; PAB1791 .
    GeneIDi 1496204.
    KEGGi pab:PAB1791.

    Phylogenomic databases

    eggNOGi COG2055.
    HOGENOMi HOG000173270.
    OMAi HFFMAID.

    Family and domain databases

    InterProi IPR003767. Malate/L-lactate_DH.
    [Graphical view ]
    PANTHERi PTHR11091. PTHR11091. 1 hit.
    Pfami PF02615. Ldh_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89733. SSF89733. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiMDH_PYRAB
    AccessioniPrimary (citable) accession number: Q9V0D5
    Secondary accession number(s): G8ZH65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3