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Protein

Malate dehydrogenase

Gene

mdh

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:PYRAB08550
ORF Names:PAB1791
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Malate dehydrogenasePRO_0000083828Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272844.PAB1791.

Structurei

3D structure databases

ProteinModelPortaliQ9V0D5.
SMRiQ9V0D5. Positions 1-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family.Curated

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
OMAiLAWDNGA.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V0D5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFEKGYVDEN YVRIPKDELF SFVVRVLTKL GTPEEDAKIV ADNLIMADLR
60 70 80 90 100
GIESHGVQRL KRYVDGILSG GINLHPRIKI IREGPSYALL DGDEGFGQVV
110 120 130 140 150
GYKAMKLAIE KARKTGIGIV AVRNSNHYGI AGYYALMAAE EGMIGISMTN
160 170 180 190 200
SRPLVAPTGG VERILGTNPI ALAAPTKGKP FLLDMATSVV PIGKLEVYRR
210 220 230 240 250
KGEEIPEGWA INSKGEITRS VEEVFNGGSL LPLGGFGELL GGHKGYGLSL
260 270 280 290 300
MVDILSGILS GGTWSKHVKN TNEKNSNVCH FFMAINIEHF TPLEEFKGRM
310 320 330 340 350
SEMINEIKNS RKHPDFERIW IHGEKGFLTM ETRLKLGIPI YKKVLDELNE
360
IARRVGVKGL EV
Length:362
Mass (Da):39,907
Last modified:May 1, 2000 - v1
Checksum:i1E15C2E9E6BA5012
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA. Translation: CAB49769.1.
HE613800 Genomic DNA. Translation: CCE70260.1.
PIRiH75131.
RefSeqiNP_126538.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49769; CAB49769; PAB1791.
GeneIDi1496204.
KEGGipab:PAB1791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA. Translation: CAB49769.1.
HE613800 Genomic DNA. Translation: CCE70260.1.
PIRiH75131.
RefSeqiNP_126538.1. NC_000868.1.

3D structure databases

ProteinModelPortaliQ9V0D5.
SMRiQ9V0D5. Positions 1-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB1791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49769; CAB49769; PAB1791.
GeneIDi1496204.
KEGGipab:PAB1791.

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
OMAiLAWDNGA.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiMDH_PYRAB
AccessioniPrimary (citable) accession number: Q9V0D5
Secondary accession number(s): G8ZH65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.