Q9V0D5 (MDH_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malate dehydrogenase
EC=1.1.1.37

Gene names

Name:	mdh
Ordered Locus Names:	PYRAB08550
ORF Names:	PAB1791

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the LDH2/MDH2 oxidoreductase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Malate dehydrogenase		PRO_0000083828

Sequences

	Sequence		Length	Mass (Da)
	Q9V0D5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1E15C2E9E6BA5012	FASTA	362	39,907
	10 20 30 40 50 60 MFEKGYVDEN YVRIPKDELF SFVVRVLTKL GTPEEDAKIV ADNLIMADLR GIESHGVQRL 70 80 90 100 110 120 KRYVDGILSG GINLHPRIKI IREGPSYALL DGDEGFGQVV GYKAMKLAIE KARKTGIGIV 130 140 150 160 170 180 AVRNSNHYGI AGYYALMAAE EGMIGISMTN SRPLVAPTGG VERILGTNPI ALAAPTKGKP 190 200 210 220 230 240 FLLDMATSVV PIGKLEVYRR KGEEIPEGWA INSKGEITRS VEEVFNGGSL LPLGGFGELL 250 260 270 280 290 300 GGHKGYGLSL MVDILSGILS GGTWSKHVKN TNEKNSNVCH FFMAINIEHF TPLEEFKGRM 310 320 330 340 350 360 SEMINEIKNS RKHPDFERIW IHGEKGFLTM ETRLKLGIPI YKKVLDELNE IARRVGVKGL EV

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248285 Genomic DNA. Translation: CAB49769.1.
PIR	H75131.
RefSeq	NP_126538.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V0D5.
SMR	Q9V0D5. Positions 1-360.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002526; EBPYRP00000002457; EBPYRG00000002526.
GeneID	1496204.
GenomeReviews	Gene locus PYRAB08550 in contig AL096836_GR.
KEGG	pab:PAB1791.
NMPDR	fig|272844.1.peg.897.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022443.
HOGENOM	HBG553037.
OMA	MYINDLA.
PhylomeDB	Q9V0D5.
ProtClustDB	CLSK865277.
Enzyme and pathway databases
BioCyc	PABY272844:PAB1791-MONOMER.
Family and domain databases
InterPro	IPR003767. Malate/L-lactate_DH. [Graphical view]
KO	K05884.
PANTHER	PTHR11091. MDH_LDH. 1 hit.
Pfam	PF02615. Ldh_2. 1 hit. [Graphical view]
SUPFAM	SSF89733. MDH_LDH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MDH_PYRAB

Accession

Primary (citable) accession number: Q9V0D5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program