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Q9V0D5 (MDH_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:PYRAB08550
ORF Names:PAB1791
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the LDH2/MDH2 oxidoreductase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Malate dehydrogenase
PRO_0000083828

Sequences

Sequence LengthMass (Da)Tools
Q9V0D5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1E15C2E9E6BA5012

FASTA36239,907
        10         20         30         40         50         60 
MFEKGYVDEN YVRIPKDELF SFVVRVLTKL GTPEEDAKIV ADNLIMADLR GIESHGVQRL 

        70         80         90        100        110        120 
KRYVDGILSG GINLHPRIKI IREGPSYALL DGDEGFGQVV GYKAMKLAIE KARKTGIGIV 

       130        140        150        160        170        180 
AVRNSNHYGI AGYYALMAAE EGMIGISMTN SRPLVAPTGG VERILGTNPI ALAAPTKGKP 

       190        200        210        220        230        240 
FLLDMATSVV PIGKLEVYRR KGEEIPEGWA INSKGEITRS VEEVFNGGSL LPLGGFGELL 

       250        260        270        280        290        300 
GGHKGYGLSL MVDILSGILS GGTWSKHVKN TNEKNSNVCH FFMAINIEHF TPLEEFKGRM 

       310        320        330        340        350        360 
SEMINEIKNS RKHPDFERIW IHGEKGFLTM ETRLKLGIPI YKKVLDELNE IARRVGVKGL 


EV 

« Hide

References

« Hide 'large scale' references
[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.
[2]"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
Gao J., Wang J.
Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: GE5 / Orsay.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ248285 Genomic DNA. Translation: CAB49769.1.
HE613800 Genomic DNA. Translation: CCE70260.1.
PIRH75131.
RefSeqNP_126538.1. NC_000868.1.

3D structure databases

ProteinModelPortalQ9V0D5.
SMRQ9V0D5. Positions 1-360.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272844.PAB1791.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB49769; CAB49769; PAB1791.
GeneID1496204.
KEGGpab:PAB1791.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2055.
HOGENOMHOG000173270.
OMAAINRCVH.
ProtClustDBCLSK865277.

Family and domain databases

InterProIPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERPTHR11091. PTHR11091. 1 hit.
PfamPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMSSF89733. SSF89733. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_PYRAB
AccessionPrimary (citable) accession number: Q9V0D5
Secondary accession number(s): G8ZH65
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: March 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families