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Q9V0B9

- SYL_PYRAB

UniProt

Q9V0B9 - SYL_PYRAB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei653 – 6531ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PYRAB08710
    ORF Names:PAB1782
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 967967Leucine--tRNA ligasePRO_0000152137Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272844.PAB1782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V0B9.
    SMRiQ9V0B9. Positions 4-967.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi650 – 6545"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9V0B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPELNFRAIE EKWQKRWLEA KVFEPNIKDK PKEKKFYITV AFPYLSGHLH    50
    VGHARTYTIP DVIARFKRMQ GYNVLFPMGW HITGSPIVGI AERIKNRDPH 100
    TIWIYRDVYK VPEEILWTFE DPVNIVKYFM KAAKETFIRA GFSVDWSREF 150
    YTTSLFPPFS KFIEWQFLKL KEKGYIVKGA HRVRWDPVVG TPLGDHDLME 200
    GEDVPILEYV IIKFELKEGD ETIYLPAATL RPETVYGVTN MWINPNATYV 250
    KAKVKRGGKE ETWIISKEAA YKLSFQDREI EVIEEFKGEK LIGKYVRNPV 300
    TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK RESEILVKYD 350
    IDPRIVEEIT YISLIKLEGY GEFPAVEEVQ KLGIKSQKDR EKLEQATKTI 400
    YKAEYHKGIF KVPPYDGKPV QEVKELIAKE MMEKGIAEIM YEFAEKNVIS 450
    RFGNRAVIKI IHDQWFIDYG NSEWKEKARK ALARMKIYPE TRRAQFEAII 500
    DWLDKKACAR KVGLGTPLPW DPEWVIESLS DSTIYMAYYT ISRHINRLRE 550
    EGRLDPEKLT PEFFDYIFLE EFSEEREKEL EKKTGIPAEI IHEMKEEFEY 600
    WYPLDWRCSG KDLIPNHLTF FIFNHVAIFR EEHWPKGIAV NGFGTLEGQK 650
    MSKSKGNVLN FIDAIEENGA DVVRLYIMSL AEHDSDFDWR RKEVGKLRRQ 700
    LERFYELISQ FAEYEAKENV ELKTIDKWLL HRLNKAIEGT TKALEEFRTR 750
    TAVQWAFYSI MNDLRWYMRR TEGRDDEAKR FVLRKLADIW VRLMAPFTPH 800
    ICEELWEKLG GEGFVSLAKW PEPVDEWWNE EVEVEEDFIK SLIEDIKEII 850
    EVAKIESPKR AYIYTAPEWK WKVYEVVAEK REFKSAMAEL MKDEEIRKHG 900
    KEVAKLVQAI IKERAFDVKR IDEEKVLRES KDFLEKELGL EVIINPEEDK 950
    GGKKRQAIPL KPAVFIE 967
    Length:967
    Mass (Da):113,824
    Last modified:May 1, 2000 - v1
    Checksum:iAA138311F00276A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248285 Genomic DNA. Translation: CAB49785.1.
    HE613800 Genomic DNA. Translation: CCE70276.1.
    PIRiH75133.
    RefSeqiNP_126554.1. NC_000868.1.
    WP_010867994.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB49785; CAB49785; PAB1782.
    GeneIDi1496220.
    KEGGipab:PAB1782.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248285 Genomic DNA. Translation: CAB49785.1 .
    HE613800 Genomic DNA. Translation: CCE70276.1 .
    PIRi H75133.
    RefSeqi NP_126554.1. NC_000868.1.
    WP_010867994.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9V0B9.
    SMRi Q9V0B9. Positions 4-967.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB1782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB49785 ; CAB49785 ; PAB1782 .
    GeneIDi 1496220.
    KEGGi pab:PAB1782.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiSYL_PYRAB
    AccessioniPrimary (citable) accession number: Q9V0B9
    Secondary accession number(s): G8ZI35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3