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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-948-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PYRAB08710
ORF Names:PAB1782
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521371 – 967Leucine--tRNA ligaseAdd BLAST967

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1782

Structurei

3D structure databases

ProteinModelPortaliQ9V0B9
SMRiQ9V0B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi650 – 654"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V0B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELNFRAIE EKWQKRWLEA KVFEPNIKDK PKEKKFYITV AFPYLSGHLH
60 70 80 90 100
VGHARTYTIP DVIARFKRMQ GYNVLFPMGW HITGSPIVGI AERIKNRDPH
110 120 130 140 150
TIWIYRDVYK VPEEILWTFE DPVNIVKYFM KAAKETFIRA GFSVDWSREF
160 170 180 190 200
YTTSLFPPFS KFIEWQFLKL KEKGYIVKGA HRVRWDPVVG TPLGDHDLME
210 220 230 240 250
GEDVPILEYV IIKFELKEGD ETIYLPAATL RPETVYGVTN MWINPNATYV
260 270 280 290 300
KAKVKRGGKE ETWIISKEAA YKLSFQDREI EVIEEFKGEK LIGKYVRNPV
310 320 330 340 350
TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK RESEILVKYD
360 370 380 390 400
IDPRIVEEIT YISLIKLEGY GEFPAVEEVQ KLGIKSQKDR EKLEQATKTI
410 420 430 440 450
YKAEYHKGIF KVPPYDGKPV QEVKELIAKE MMEKGIAEIM YEFAEKNVIS
460 470 480 490 500
RFGNRAVIKI IHDQWFIDYG NSEWKEKARK ALARMKIYPE TRRAQFEAII
510 520 530 540 550
DWLDKKACAR KVGLGTPLPW DPEWVIESLS DSTIYMAYYT ISRHINRLRE
560 570 580 590 600
EGRLDPEKLT PEFFDYIFLE EFSEEREKEL EKKTGIPAEI IHEMKEEFEY
610 620 630 640 650
WYPLDWRCSG KDLIPNHLTF FIFNHVAIFR EEHWPKGIAV NGFGTLEGQK
660 670 680 690 700
MSKSKGNVLN FIDAIEENGA DVVRLYIMSL AEHDSDFDWR RKEVGKLRRQ
710 720 730 740 750
LERFYELISQ FAEYEAKENV ELKTIDKWLL HRLNKAIEGT TKALEEFRTR
760 770 780 790 800
TAVQWAFYSI MNDLRWYMRR TEGRDDEAKR FVLRKLADIW VRLMAPFTPH
810 820 830 840 850
ICEELWEKLG GEGFVSLAKW PEPVDEWWNE EVEVEEDFIK SLIEDIKEII
860 870 880 890 900
EVAKIESPKR AYIYTAPEWK WKVYEVVAEK REFKSAMAEL MKDEEIRKHG
910 920 930 940 950
KEVAKLVQAI IKERAFDVKR IDEEKVLRES KDFLEKELGL EVIINPEEDK
960
GGKKRQAIPL KPAVFIE
Length:967
Mass (Da):113,824
Last modified:May 1, 2000 - v1
Checksum:iAA138311F00276A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA Translation: CAB49785.1
HE613800 Genomic DNA Translation: CCE70276.1
PIRiH75133
RefSeqiWP_010867994.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49785; CAB49785; PAB1782
GeneIDi1496220
KEGGipab:PAB1782
PATRICifig|272844.11.peg.919

Similar proteinsi

Entry informationi

Entry nameiSYL_PYRAB
AccessioniPrimary (citable) accession number: Q9V0B9
Secondary accession number(s): G8ZI35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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