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Q9V0B9

- SYL_PYRAB

UniProt

Q9V0B9 - SYL_PYRAB

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei653 – 6531ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PYRAB08710
ORF Names:PAB1782
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Leucine--tRNA ligasePRO_0000152137Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1782.

Structurei

3D structure databases

ProteinModelPortaliQ9V0B9.
SMRiQ9V0B9. Positions 4-967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi650 – 6545"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V0B9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPELNFRAIE EKWQKRWLEA KVFEPNIKDK PKEKKFYITV AFPYLSGHLH
60 70 80 90 100
VGHARTYTIP DVIARFKRMQ GYNVLFPMGW HITGSPIVGI AERIKNRDPH
110 120 130 140 150
TIWIYRDVYK VPEEILWTFE DPVNIVKYFM KAAKETFIRA GFSVDWSREF
160 170 180 190 200
YTTSLFPPFS KFIEWQFLKL KEKGYIVKGA HRVRWDPVVG TPLGDHDLME
210 220 230 240 250
GEDVPILEYV IIKFELKEGD ETIYLPAATL RPETVYGVTN MWINPNATYV
260 270 280 290 300
KAKVKRGGKE ETWIISKEAA YKLSFQDREI EVIEEFKGEK LIGKYVRNPV
310 320 330 340 350
TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK RESEILVKYD
360 370 380 390 400
IDPRIVEEIT YISLIKLEGY GEFPAVEEVQ KLGIKSQKDR EKLEQATKTI
410 420 430 440 450
YKAEYHKGIF KVPPYDGKPV QEVKELIAKE MMEKGIAEIM YEFAEKNVIS
460 470 480 490 500
RFGNRAVIKI IHDQWFIDYG NSEWKEKARK ALARMKIYPE TRRAQFEAII
510 520 530 540 550
DWLDKKACAR KVGLGTPLPW DPEWVIESLS DSTIYMAYYT ISRHINRLRE
560 570 580 590 600
EGRLDPEKLT PEFFDYIFLE EFSEEREKEL EKKTGIPAEI IHEMKEEFEY
610 620 630 640 650
WYPLDWRCSG KDLIPNHLTF FIFNHVAIFR EEHWPKGIAV NGFGTLEGQK
660 670 680 690 700
MSKSKGNVLN FIDAIEENGA DVVRLYIMSL AEHDSDFDWR RKEVGKLRRQ
710 720 730 740 750
LERFYELISQ FAEYEAKENV ELKTIDKWLL HRLNKAIEGT TKALEEFRTR
760 770 780 790 800
TAVQWAFYSI MNDLRWYMRR TEGRDDEAKR FVLRKLADIW VRLMAPFTPH
810 820 830 840 850
ICEELWEKLG GEGFVSLAKW PEPVDEWWNE EVEVEEDFIK SLIEDIKEII
860 870 880 890 900
EVAKIESPKR AYIYTAPEWK WKVYEVVAEK REFKSAMAEL MKDEEIRKHG
910 920 930 940 950
KEVAKLVQAI IKERAFDVKR IDEEKVLRES KDFLEKELGL EVIINPEEDK
960
GGKKRQAIPL KPAVFIE
Length:967
Mass (Da):113,824
Last modified:May 1, 2000 - v1
Checksum:iAA138311F00276A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248285 Genomic DNA. Translation: CAB49785.1.
HE613800 Genomic DNA. Translation: CCE70276.1.
PIRiH75133.
RefSeqiNP_126554.1. NC_000868.1.
WP_010867994.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49785; CAB49785; PAB1782.
GeneIDi1496220.
KEGGipab:PAB1782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248285 Genomic DNA. Translation: CAB49785.1 .
HE613800 Genomic DNA. Translation: CCE70276.1 .
PIRi H75133.
RefSeqi NP_126554.1. NC_000868.1.
WP_010867994.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9V0B9.
SMRi Q9V0B9. Positions 4-967.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB1782.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB49785 ; CAB49785 ; PAB1782 .
GeneIDi 1496220.
KEGGi pab:PAB1782.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiSYL_PYRAB
AccessioniPrimary (citable) accession number: Q9V0B9
Secondary accession number(s): G8ZI35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3