Q9V085 (METE_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable methylcobalamin:homocysteine methyltransferase
EC=2.1.1.-

Alternative name(s):
Methionine synthase

Gene names

Name:	metE
Ordered Locus Names:	PYRAB09060
ORF Names:	PAB0608

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from methylcobalamin and methylcobinamide to homocysteine resulting in methionine formation By similarity. HAMAP MF_00288
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00288
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway. HAMAP MF_00288
Sequence similarities	Belongs to the vitamin-B12 independent methionine synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Probable methylcobalamin:homocysteine methyltransferase HAMAP MF_00288		PRO_0000098687
Sites
	Metal binding	210	1	Zinc By similarity
	Metal binding	212	1	Zinc By similarity
	Metal binding	294	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V085 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F3A3F94CC04601EB	FASTA	338	39,434
	10 20 30 40 50 60 MELPILPTSV IGSYPKPRWL LRMYKLRELG KIPEEDFKEA VKDASVAVLR EHERAGVDIP 70 80 90 100 110 120 WDGEMWRSEM TEHFTAKISG FKFYGPVRVW GNAYFNKAAA VDKLEYKEPL VLEEFLWVRE 130 140 150 160 170 180 NTTREIVKVP ITGPYTIAEW SFNEYYPDKE SFVMDLAKII NKELKTLEEH GATYIQLDEP 190 200 210 220 230 240 AMLNHPDEVP LAVEAINRAV KGIKIKVGLH VCYSNYYLLA DYFDDIRVTQ FALEFANRQF 250 260 270 280 290 300 RDMDFLKKLS GKELGFGVVD VHNPRIETVD EIVRAIKKAF NYLEPEWLYI NPDCGLKLLD 310 320 330 RRIAYQKLVN MVKAVRIVRK ELEKEGRAET EFRTLNDI

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248285 Genomic DNA. Translation: CAB49820.1.
PIR	C75138.
RefSeq	NP_126589.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V085.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002306; EBPYRP00000002237; EBPYRG00000002306.
GeneID	1496258.
GenomeReviews	Gene locus PYRAB09060 in contig AL096836_GR.
KEGG	pab:PAB0608.
NMPDR	fig|272844.1.peg.951.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022830.
HOGENOM	HBG539650.
OMA	DPDCGMR.
PhylomeDB	Q9V085.
ProtClustDB	PRK04326.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0608-MONOMER.
Family and domain databases
HAMAP	MF_00288. MetE. [Tree]
InterPro	IPR022921. MetE_arc. IPR002629. Methionine_synth. [Graphical view]
KO	K00549.
Pfam	PF01717. Meth_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

METE_PYRAB

Accession

Primary (citable) accession number: Q9V085

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program