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Protein

NAD kinase

Gene

nadK

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorUniRule annotation1
Binding sitei72NADUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei167NADUniRule annotation1
Binding sitei202NAD; via carbonyl oxygenUniRule annotation1
Binding sitei236NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 68NADUniRule annotation2
Nucleotide bindingi137 – 138NADUniRule annotation2
Nucleotide bindingi178 – 183NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-990-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PYRAB09100
ORF Names:PAB1756
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207051 – 277NAD kinaseAdd BLAST277

Proteomic databases

PRIDEiQ9V081

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1756

Structurei

3D structure databases

ProteinModelPortaliQ9V081
SMRiQ9V081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348 Archaea
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFGIVARRD REEALKLAYR VYDYLKVRGY DAIVDSETYE HFPHFKEEDI
60 70 80 90 100
AKLEEFDVDF IIAIGGDGTI LRIEHKTKKD IPILSINMGT LGFLTEVEPS
110 120 130 140 150
ETFFAINRLL RGEYYIDERI KLRTYINGEA RIPDALNEVA ILTGIPGKVI
160 170 180 190 200
HLRYYVDGGL ADEVRADGLV VATPTGSTGY AMSAGGPFVD PRLDTIIIAP
210 220 230 240 250
LLPLPRTSVP MVVPGYSKIE IEFVTKREVI LAVDGQYYEH LSPDIKIRIE
260 270
KSPRKTKFVR FTREIYPKYT MRIKERH
Length:277
Mass (Da):31,673
Last modified:May 1, 2000 - v1
Checksum:i1A93BF709D5C5EF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248285 Genomic DNA Translation: CAB49824.1
HE613800 Genomic DNA Translation: CCE70318.1
PIRiG75138
RefSeqiWP_010868033.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49824; CAB49824; PAB1756
GeneIDi1496262
KEGGipab:PAB1756
PATRICifig|272844.11.peg.963

Similar proteinsi

Entry informationi

Entry nameiNADK_PYRAB
AccessioniPrimary (citable) accession number: Q9V081
Secondary accession number(s): G8ZI77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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