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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37TyrosineUniRule annotation1
Binding sitei168TyrosineUniRule annotation1
Binding sitei172TyrosineUniRule annotation1
Binding sitei175TyrosineUniRule annotation1
Binding sitei190TyrosineUniRule annotation1
Binding sitei254ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1052-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:PYRAB09710
ORF Names:PAB1728
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002402651 – 375Tyrosine--tRNA ligaseAdd BLAST375

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB1728.

Structurei

3D structure databases

ProteinModelPortaliQ9V027.
SMRiQ9V027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi251 – 255"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01886. Archaea.
COG0162. LUCA.
HOGENOMiHOG000228238.
KOiK01866.
OMAiYIGFEIS.
OrthoDBiPOG093Z05HU.

Family and domain databases

CDDicd00805. TyrRS_core. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_02009. Tyr_tRNA_synth_type4. 1 hit.
InterProiView protein in InterPro
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002307. Tyr-tRNA-ligase.
IPR023678. Tyr-tRNA-ligase_4.
IPR023617. Tyr-tRNA-ligase_arc/euk-type.
PfamiView protein in Pfam
PF00579. tRNA-synt_1b. 1 hit.
PIRSFiPIRSF006588. TyrRS_arch_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEERINLV LKKPTEEVLT VENLRHLFEV GAPLQHYIGF EISGYIHLGT
60 70 80 90 100
GLMAGAKIAD FQKAGIKTRI FLADWHSWIN DKLGGDLEVI QEVALKYFKV
110 120 130 140 150
GMEKSIEVMG GDPKKVEFVL ASEILENGDY WQTVIDISKN VTLSRVMRSI
160 170 180 190 200
TIMGRQMGES IDFAKLIYPM MQVADIFYQG VTIAHAGMDQ RKAHVIAIEV
210 220 230 240 250
AQKLKYHPIV HNGEKLKPVA VHHHLLLGLQ EPPVWPITSE EQFKEIKAQM
260 270 280 290 300
KMSKSKPYSA VFIHDSPEEI KQKLRKAFCP AREVNYNPVL DWAEHIIFRE
310 320 330 340 350
EPTEFTIHRP AKFGGDVTYT TFEELKKDFA EGKLHPLDLK NAVAEYLIEL
360 370
LKPIREYFER HPEPLELMRS VKITR
Length:375
Mass (Da):43,054
Last modified:May 1, 2000 - v1
Checksum:i1437665DBF82113C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248286 Genomic DNA. Translation: CAB49879.1.
HE613800 Genomic DNA. Translation: CCE70377.1.
PIRiB75072.
RefSeqiWP_010868088.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49879; CAB49879; PAB1728.
GeneIDi1496321.
KEGGipab:PAB1728.
PATRICifig|272844.11.peg.1023.

Similar proteinsi

Entry informationi

Entry nameiSYY_PYRAB
AccessioniPrimary (citable) accession number: Q9V027
Secondary accession number(s): G8ZID6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome