Q9UZV9 (Q9UZV9_PYRAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Asd aspartate-semialdehyde dehydrogenase EMBL CAB49947.1

Submitted name:
Aspartate-semialdehyde dehydrogenase EMBL CCE70446.1

Gene names

Name:	asd EMBL CCE70446.1
Ordered Locus Names:	PAB1678 EMBL CAB49947.1, PYRAB10370

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family. RuleBase RU004041

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aspartate metabolic process Inferred from electronic annotation. Source: InterPro isoleucine biosynthetic process Inferred from electronic annotation. Source: InterPro lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro methionine biosynthetic process Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: InterPro NAD binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from electronic annotation. Source: InterPro aspartate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	143	1	Acyl-thioester intermediate By similarity PIRSR PIRSR000148-1
	Active site	235	1	Proton acceptor By similarity PIRSR PIRSR000148-1

Sequences

	Sequence		Length	Mass (Da)
	Q9UZV9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 4A26E57A921CDA99	FASTA	335	37,164
	10 20 30 40 50 60 MKRVAVLGAT GLVGRTFVKL LGGHPWFKVE KLIASEKSAG KKYGDLVEDS PEEFRDYYVI 70 80 90 100 110 120 SLNEFLENPG VDLVFNALPA SISRDVEEKL AQEIPVFTNA RAHRYDEDVP ILVPEVNKDH 130 140 150 160 170 180 LKLVEVQRKR RGWKGFIVTN PNCSTAILTL SLAPLRNFGI KKVRVATMQA ISGAGFSGLS 190 200 210 220 230 240 AYAIQDNVIP FISGEEWKIE NESKKIMGKL KGDEIEPASF DVIAIATRVP VIHGHTEAVF 250 260 270 280 290 300 VELENPDIKS IREAIENFDP LKDLKLPSYE KPIVYTEIPQ PRLHRDRGRG LTVTVGRLER 310 320 330 TSEGVKYVAL GHNLVRGAAG GSVLNAELAY KLKII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	Gao J. Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: GE5 EMBL CCE70446.1.
[3]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.
[4]	"Re-annotation of Two Hyperthermophilic Archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 0:0-0(0) Cited for: NUCLEOTIDE SEQUENCE. Strain: GE5 EMBL CCE70446.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248286 Genomic DNA. Translation: CAB49947.1. HE613800 Genomic DNA. Translation: CCE70446.1.
PIR	F75080.
RefSeq	NP_126716.1. NC_000868.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272844.PAB1678.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB49947; CAB49947; PAB1678.
GeneID	1496391.
KEGG	pab:PAB1678.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0136.
HOGENOM	HOG000013358.
KO	K00133.
OMA	VIDGHTE.
ProtClustDB	PRK08664.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR005676. Asp_semi-ald_DH_pep-lack. IPR012080. Asp_semialdehyde_DH. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
PIRSF	PIRSF000148. ASA_dh. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR00978. asd_EA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q9UZV9_PYRAB

Accession

Primary (citable) accession number: Q9UZV9

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)