Q9UZV8 (Q9UZV8_PYRAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Threonine synthase PIRNR PIRNR038945
EC=4.2.3.1 PIRNR PIRNR038945

Gene names

Name:	thrC-2 EMBL CCE70447.1
Ordered Locus Names:	PAB1677 EMBL CAB49948.1, PYRAB10380

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity. PIRNR PIRNR038945
Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate. PIRNR PIRNR038945
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038945
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate. PIRNR PIRNR038945
Sequence similarities	Belongs to the threonine synthase family. PIRNR PIRNR038945

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis PIRNR PIRNR038945
Ligand	Pyridoxal phosphate PIRNR PIRNR038945
Molecular function	Lyase PIRNR PIRNR038945
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9UZV8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7F40625AC467CF17	FASTA	394	43,368
	10 20 30 40 50 60 MVLRCIRCGR EYPEDEIRYR CECGGLLEVV VDLDKVDTKI FDGNNITLWK YESWLPVKKI 70 80 90 100 110 120 VSLNEGGTPL YRLNNLEKIL GVKELYAKNE GANPTGSFKD RGMTVGVSKA LELGMKRVAC 130 140 150 160 170 180 ASTGNTSASL AAYAAKAGIE AYVLVPSGKI ALGKLAQAII YGAKVIPIKG NFDDALRVVI 190 200 210 220 230 240 EASEELGIYM LNSINPFRLE GQKTIAYEIY DQLQKVPDNV VLPVGNAGNI SAIWKGFKEL 250 260 270 280 290 300 YEAGVIDKLP RMIGIQAEGA SPLAKAWKEK RKFKPEKNPE TLATAIRIGN PANWEKAWRA 310 320 330 340 350 360 VEESGGMFEI VSDEEILKAQ RILASKEGLF VEPASAASLA GLIKLLNEEK VDRDESFVLV 370 380 390 TTGHGLKDPD IVLRNFKLPE PIEPTLDAFR RVIE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	Gao J. Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: GE5 EMBL CCE70447.1.
[3]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.
[4]	"Re-annotation of Two Hyperthermophilic Archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 0:0-0(0) Cited for: NUCLEOTIDE SEQUENCE. Strain: GE5 EMBL CCE70447.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248286 Genomic DNA. Translation: CAB49948.1. HE613800 Genomic DNA. Translation: CCE70447.1.
PIR	G75080.
RefSeq	NP_126717.1. NC_000868.1.
3D structure databases
HSSP	HSSP built from PDB template 1E5X based on UniProtKB Q9S7B5.
SMR	Q9UZV8. Positions 47-393.
ModBase	Search...
Protein-protein interaction databases
STRING	272844.PAB1677.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB49948; CAB49948; PAB1677.
GeneID	1496392.
KEGG	pab:PAB1677.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0498.
HOGENOM	HOG000076502.
KO	K01733.
OMA	KCIVLLP.
ProtClustDB	PRK06260.
Family and domain databases
InterPro	IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR026260. Thr_Synthase. IPR004450. Thr_synthase_like. IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF038945. Thr_synthase. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9UZV8_PYRAB

Accession

Primary (citable) accession number: Q9UZV8

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)