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Q9UZQ4

- THIM_PYRAB

UniProt

Q9UZQ4 - THIM_PYRAB

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, PYRAB10910, PAB2432
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Substrate; via amide nitrogen By similarity
Binding sitei118 – 1181ATP By similarity
Binding sitei165 – 1651ATP By similarity
Binding sitei192 – 1921Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:PYRAB10910
ORF Names:PAB2432
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000156970Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB2432.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UZQ4-1 [UniParc]FASTAAdd to Basket

« Hide

MNFIVEALNE VRKRKPLVHN ITNFVVMNTT ANALLALGAS PVMAHAEEEL    50
EEMIGLADAV VINIGTLDSW WRKSMIKAVE IANEMKKPIV LDPVGAGATK 100
LRTKVALEIL DRGVTVLKGN FGEISSLLGE FGKTRGVDSS EYDEEKAKVL 150
ALSAAKEFNT TVAVTGAVDY VSDGGKVFAI YNGHKLLERV TGTGCIVTAI 200
TGAFVAVTEP LRAAISSLVV FGIAAEKAYE EAKYPGSFHV KLYDWLYRID 250
GEVIRKYAKV REVGV 265
Length:265
Mass (Da):28,705
Last modified:May 16, 2012 - v2
Checksum:i5E7C4084BA3C5A18
GO

Sequence cautioni

The sequence CAB50002.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248286 Genomic DNA. Translation: CAB50002.1. Different initiation.
HE613800 Genomic DNA. Translation: CCE70504.1.
PIRiE75087.
RefSeqiNP_126771.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50002; CAB50002; PAB2432.
GeneIDi1496449.
KEGGipab:PAB2432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248286 Genomic DNA. Translation: CAB50002.1 . Different initiation.
HE613800 Genomic DNA. Translation: CCE70504.1 .
PIRi E75087.
RefSeqi NP_126771.1. NC_000868.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 272844.PAB2432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB50002 ; CAB50002 ; PAB2432 .
GeneIDi 1496449.
KEGGi pab:PAB2432.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiTHIM_PYRAB
AccessioniPrimary (citable) accession number: Q9UZQ4
Secondary accession number(s): G8ZJP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 16, 2012
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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