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Protein

Ribonuclease Z

Gene

rnz

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Zinc 1; catalyticUniRule annotation1
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Active sitei65Proton acceptorUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi138Zinc 1; catalyticUniRule annotation1
Metal bindingi208Zinc 1; catalyticUniRule annotation1
Metal bindingi208Zinc 2; catalyticUniRule annotation1
Metal bindingi264Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1195-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:PYRAB11010
ORF Names:PAB0728
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559311 – 307Ribonuclease ZAdd BLAST307

Proteomic databases

PRIDEiQ9UZP4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB0728

Structurei

3D structure databases

ProteinModelPortaliQ9UZP4
SMRiQ9UZP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501 Archaea
COG1234 LUCA
HOGENOMiHOG000272419
KOiK00784
OMAiGTQRQMM
OrthoDBiPOG093Z04VY

Family and domain databases

CDDicd07717 RNaseZ_ZiPD-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01818 RNase_Z_BN, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR013471 RNase_Z/BN
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR02651 RNase_Z, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UZP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVIFLGTG GIKPTPERNV PSIAIKVEGE LILFDVGEGT LRQMEIAGLS
60 70 80 90 100
PMKIRRIFIT HFHGDHYLGL PALIQTMNLW KRKEPLHIYG PENSIEFIKN
110 120 130 140 150
LLNSGYFAPS FDVTVHELPG KARLQFEKYE VWAFEVSHGV PALGYVFKEK
160 170 180 190 200
DRRGSFDLEK IKNLGLEPGP WMKELEEKKV INIGGRTIRL SEVTGPKKRG
210 220 230 240 250
AKIVYTGDTE PCENVIQFSR RANLLIHEAT YLNSEDRGES YHTTVEEACE
260 270 280 290 300
IWKKSKAFNL ALFHRGPRYS FKEYKEGATK LCPQAMIPRD FDRIMVKGAE

YVIFKVR
Length:307
Mass (Da):35,131
Last modified:May 1, 2000 - v1
Checksum:iC17E2BFB0C9F3BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248286 Genomic DNA Translation: CAB50012.1
HE613800 Genomic DNA Translation: CCE70514.1
PIRiG75088
RefSeqiWP_010868219.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB50012; CAB50012; PAB0728
GeneIDi1496459
KEGGipab:PAB0728
PATRICifig|272844.11.peg.1157

Similar proteinsi

Entry informationi

Entry nameiRNZ_PYRAB
AccessioniPrimary (citable) accession number: Q9UZP4
Secondary accession number(s): G8ZJQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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