Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative adenylate kinase

Gene

PYRAB11420

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961ATPUniRule annotation
Binding sitei100 – 1001ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenylate kinaseUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AKUniRule annotation
Alternative name(s):
ATP-AMP transphosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:PYRAB11420
ORF Names:PAB0757
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Putative adenylate kinasePRO_0000153910Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0757.

Structurei

Secondary structure

180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 66Combined sources
Helixi13 – 2412Combined sources
Beta strandi27 – 304Combined sources
Helixi31 – 377Combined sources
Beta strandi42 – 443Combined sources
Beta strandi47 – 504Combined sources
Helixi52 – 6211Combined sources
Turni63 – 653Combined sources
Beta strandi66 – 727Combined sources
Helixi75 – 773Combined sources
Beta strandi81 – 877Combined sources
Helixi90 – 10011Combined sources
Helixi104 – 11512Combined sources
Helixi118 – 1269Combined sources
Beta strandi130 – 1345Combined sources
Helixi140 – 15213Combined sources
Helixi164 – 1674Combined sources
Helixi168 – 1714Combined sources
Helixi172 – 1743Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CVNX-ray2.12A/B/C/D1-180[»]
4CW7X-ray2.46A/C/E/G1-180[»]
ProteinModelPortaliQ9UZK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 5021NMPbindUniRule annotationAdd
BLAST
Regioni99 – 10911LIDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01038. Archaea.
COG1936. LUCA.
HOGENOMiHOG000224471.
KOiK18532.
OMAiVDWSEVY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UZK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIAITGTPG VGKTTIAKLL AEKLGYEYVN LRDFALEKGC GREVDGEVEV
60 70 80 90 100
EIDELAYFVE KELKDRNVVL DGHLSHLMPV DLVVVLRAHP RIIGERLRER
110 120 130 140 150
GYSKEKIGEN VEAELVDAIL IEAIDEHENV IEVDTTNKTP EEIVEEIIGL
160 170 180
IKSGVKRRVG IVDWSEVYDE IIPYLRLGGE
Length:180
Mass (Da):20,205
Last modified:May 1, 2000 - v1
Checksum:iA6D0C05F18DB992A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248286 Genomic DNA. Translation: CAB50053.1.
HE613800 Genomic DNA. Translation: CCE70558.1.
PIRiH75093.
RefSeqiWP_010868259.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50053; CAB50053; PAB0757.
GeneIDi1496504.
KEGGipab:PAB0757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248286 Genomic DNA. Translation: CAB50053.1.
HE613800 Genomic DNA. Translation: CCE70558.1.
PIRiH75093.
RefSeqiWP_010868259.1. NC_000868.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CVNX-ray2.12A/B/C/D1-180[»]
4CW7X-ray2.46A/C/E/G1-180[»]
ProteinModelPortaliQ9UZK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50053; CAB50053; PAB0757.
GeneIDi1496504.
KEGGipab:PAB0757.

Phylogenomic databases

eggNOGiarCOG01038. Archaea.
COG1936. LUCA.
HOGENOMiHOG000224471.
KOiK18532.
OMAiVDWSEVY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiKAD6_PYRAB
AccessioniPrimary (citable) accession number: Q9UZK4
Secondary accession number(s): G8ZKB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.