Q9UZC0 (MPGP_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannosyl-3-phosphoglycerate phosphatase
Short name=MPGP
EC=3.1.3.70

Gene names

Name:	mngB
Ordered Locus Names:	PYRAB12280
ORF Names:	PAB0817

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG) By similarity. HAMAP MF_00617
Catalytic activity	2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate. HAMAP MF_00617
Pathway	Carbohydrate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2. HAMAP MF_00617
Subcellular location	Cytoplasm By similarity HAMAP MF_00617.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. MPGP family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mannosylglycerate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	mannosyl-3-phosphoglycerate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Mannosyl-3-phosphoglycerate phosphatase HAMAP MF_00617		PRO_0000184971

Sequences

	Sequence		Length	Mass (Da)
	Q9UZC0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8BFD520FF47D3939	FASTA	243	28,307
	10 20 30 40 50 60 MIKVIFLDID KTLIPSYDPE PAEPVIKELK RKGFEIVFNS SKTRAEQEFY REKLDVKTPF 70 80 90 100 110 120 ISENGSAIYI PKNYFPFEIK GRETKDYIVI ELGVKVEEIR RELRKLEDAY GIKYYANSTK 130 140 150 160 170 180 EEIMEFTGMP EELVPLAMER EYSETIFKWS RESWKRTLSE RGFTVTMGSR FYSVHGNCDK 190 200 210 220 230 240 GKAAKILLEL YRRLGPVRSY AVGDGYNDFP MFDVVDRAFL IGNLTHEKAQ NVSSIMEVLE VIE

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248286 Genomic DNA. Translation: CAB50139.1.
PIR	F75104.
RefSeq	NP_126909.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9UZC0.
SMR	Q9UZC0. Positions 1-243.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003598; EBPYRP00000003529; EBPYRG00000003598.
GeneID	1496615.
GenomeReviews	Gene locus PYRAB12280 in contig AL096836_GR.
KEGG	pab:PAB0817.
NMPDR	fig|272844.1.peg.1308.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023295.
HOGENOM	HBG635303.
OMA	EYSETIF.
PhylomeDB	Q9UZC0.
ProtClustDB	PRK00192.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0817-MONOMER.
Family and domain databases
HAMAP	MF_00617. MPGP_rel. [Tree]
InterPro	IPR023214. HAD-like_dom. IPR013200. HAD-SF_hydro-like_3. IPR006379. HAD-SF_hydro_IIB. IPR006381. HAD-SF_hydro_IIB_YedP. IPR012815. MPG_Pase. IPR012813. Osmo_MPG_phos. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K07026.
Pfam	PF08282. Hydrolase_3. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit. TIGR01486. HAD-SF-IIB-MPGP. 1 hit. TIGR02461. Osmo_MPG_phos. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MPGP_PYRAB

Accession

Primary (citable) accession number: Q9UZC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program