ID   IORA_PYRAB              Reviewed;         648 AA.
AC   Q9UZ57;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Indolepyruvate oxidoreductase subunit iorA;
DE            Short=IOR;
DE            EC=1.2.7.8;
DE   AltName: Full=Indolepyruvate ferredoxin oxidoreductase subunit alpha;
GN   Name=iorA; OrderedLocusNames=PYRAB12970; ORFNames=PAB0855;
OS   Pyrococcus abyssi.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=29292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   MEDLINE=22511545; PubMed=12622808;
RX   DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C.,
RA   Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic
RT   archaeon Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
CC   -!- FUNCTION: Catalyzes the ferredoxin-dependent oxidative
CC       decarboxylation of arylpyruvates (By similarity).
CC   -!- CATALYTIC ACTIVITY: (Indol-3-yl)pyruvate + CoA + 2 oxidized
CC       ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster.
CC   -!- SUBUNIT: Heterodimer of the iorA and iorB subunits.
CC   -!- SIMILARITY: Contains 2 4Fe-4S ferredoxin-type domains.
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DR   EMBL; AJ248287; CAB50202.1; -; Genomic_DNA.
DR   PIR; E75038; E75038.
DR   RefSeq; NP_126972.1; -.
DR   HSSP; O28604; 1JNR.
DR   GeneID; 1496683; -.
DR   GenomeReviews; AL096836_GR; PYRAB12970.
DR   KEGG; pab:PAB0855; -.
DR   NMPDR; fig|272844.1.peg.1376; -.
DR   HOGENOM; Q9UZ57; -.
DR   OMA; Q9UZ57; VADDPSM.
DR   BioCyc; PABY272844:PAB0855-MON; -.
DR   BRENDA; 1.2.7.8; 262861.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase ac...; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamin pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd_subgr.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017721; Indolepyruvate_Fd_OxRdtase_asu.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR011766; TPP_enzyme_bd_C.
DR   Pfam; PF00037; Fer4; 2.
DR   Pfam; PF01855; POR_N; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   TIGRFAMs; TIGR03336; IOR_alpha; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur;
KW   Metal-binding; Oxidoreductase; Repeat; Transport.
FT   CHAIN         1    648       Indolepyruvate oxidoreductase subunit
FT                                iorA.
FT                                /FTId=PRO_0000099928.
FT   DOMAIN      585    614       4Fe-4S ferredoxin-type 1.
FT   DOMAIN      616    645       4Fe-4S ferredoxin-type 2.
FT   METAL       625    625       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       628    628       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       631    631       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       635    635       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   648 AA;  71355 MW;  069AD8E4052098F4 CRC64;
     MVKVTDIVLW DKPGERVLLL GNQAIVRGAL EGNIGVYAAY PGTPSSEITD TMAAVASRAG
     VYMEYSTNEK VAFETALSAS WAGLRAMTAM KHVGLNVAMD SFMTVSYMGV NGGLVVVVAD
     DPSMWSSQNE QDTRAIAKFA NIPVLEPSSV QEAKDMVKYA FEISEKYGQM VILRTTTRSS
     HMRGDVVLGE LPQEIKEGKR KFGDFKKNPE RYVDIPAFQR PKHKWLLETI EKFREEFNNS
     PFNWIEGPED AKVGIIAPGL SYAYVKEALA WLGVDNVKVL KLGTPFPVPY GLLEKFFQGL
     ERVLIVEELE PVVEEQVKVW AFDKGINVEI HGKDLVPRVY EMTTRRAVEA IAKFLGLETP
     INFEEIDEKY KKVQEIVPPR PPSLCPACPH RNTFFALRKA ATPRAIYPSD IGCYTLGVLP
     PLKTVDTTIA MGGSIGVAHG LSIALNGSIA EEQRKTGKGK KIIAATIGDS TFFHTGLPAL
     ANAIYNRSNV LIVVLDNLVT AMTGDQPNPG TGETPHGPGK RILIEEVAKA MGADFVAVVD
     PYDIKETYET FKKALEVEGV SVVVARRACA LYRIGQLRRA GKQWPIYQVN EDKCTGCKIC
     INAYGCPAIY WDPEKKKAKV DPLMCWGCGG CAQVCPFDAF EKVREGEL
//