Reviewed, UniProtKB/Swiss-Prot Q9UZ57 (IORA_PYRAB)

Names and origin

Protein names

Recommended name:
    Indolepyruvate oxidoreductase subunit iorA
      Short name=IOR
    EC=1.2.7.8
Alternative name(s):
    Indolepyruvate ferredoxin oxidoreductase subunit alpha

Gene names

Name:	iorA
Ordered Locus Names:	PYRAB12970
ORF Names:	PAB0855

Organism

Pyrococcus abyssi [Complete proteome] [HAMAP]

Taxonomic identifier

29292 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates By similarity.
Catalytic activity	(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced ferredoxin + H(+).
Cofactor	Binds 1 4Fe-4S cluster.
Subunit structure	Heterodimer of the iorA and iorB subunits.
Sequence similarities	Contains 2 4Fe-4S ferredoxin-type domains.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Repeat
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW indolepyruvate ferredoxin oxidoreductase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 648	648	Indolepyruvate oxidoreductase subunit iorA		PRO_0000099928
Regions
	Domain	585 – 614	30	4Fe-4S ferredoxin-type 1
	Domain	616 – 645	30	4Fe-4S ferredoxin-type 2
Sites
	Metal binding	625	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	628	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	631	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	635	1	Iron-sulfur (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9UZ57-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 069AD8E4052098F4	FASTA	648	71,355
	10 20 30 40 50 60 MVKVTDIVLW DKPGERVLLL GNQAIVRGAL EGNIGVYAAY PGTPSSEITD TMAAVASRAG 70 80 90 100 110 120 VYMEYSTNEK VAFETALSAS WAGLRAMTAM KHVGLNVAMD SFMTVSYMGV NGGLVVVVAD 130 140 150 160 170 180 DPSMWSSQNE QDTRAIAKFA NIPVLEPSSV QEAKDMVKYA FEISEKYGQM VILRTTTRSS 190 200 210 220 230 240 HMRGDVVLGE LPQEIKEGKR KFGDFKKNPE RYVDIPAFQR PKHKWLLETI EKFREEFNNS 250 260 270 280 290 300 PFNWIEGPED AKVGIIAPGL SYAYVKEALA WLGVDNVKVL KLGTPFPVPY GLLEKFFQGL 310 320 330 340 350 360 ERVLIVEELE PVVEEQVKVW AFDKGINVEI HGKDLVPRVY EMTTRRAVEA IAKFLGLETP 370 380 390 400 410 420 INFEEIDEKY KKVQEIVPPR PPSLCPACPH RNTFFALRKA ATPRAIYPSD IGCYTLGVLP 430 440 450 460 470 480 PLKTVDTTIA MGGSIGVAHG LSIALNGSIA EEQRKTGKGK KIIAATIGDS TFFHTGLPAL 490 500 510 520 530 540 ANAIYNRSNV LIVVLDNLVT AMTGDQPNPG TGETPHGPGK RILIEEVAKA MGADFVAVVD 550 560 570 580 590 600 PYDIKETYET FKKALEVEGV SVVVARRACA LYRIGQLRRA GKQWPIYQVN EDKCTGCKIC 610 620 630 640 INAYGCPAIY WDPEKKKAKV DPLMCWGCGG CAQVCPFDAF EKVREGEL

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ248287 Genomic DNA. Translation: CAB50202.1.
PIR	E75038.
RefSeq	NP_126972.1.
3D structure databases
HSSP	HSSP built from PDB template 1JNR based on UniProtKB O28604.
ModBase	Search...
Genome annotation databases
GeneID	1496683.
GenomeReviews	Gene locus PYRAB12970 in contig AL096836_GR.
KEGG	pab:PAB0855.
NMPDR	fig|272844.1.peg.1376.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9UZ57.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0855-MON.
Family and domain databases
InterPro	IPR001450. 4Fe4S_Fe_S_bd. IPR017721. Indolepyruvate_Fd_OxRdtase_asu. IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR011766. TPP_enzyme_bd_C. [Graphical view]
Pfam	PF00037. Fer4. 2 hits. PF01855. POR_N. 1 hit. PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
PRINTS	PR00353. 4FE4SFRDOXIN.
PROSITE	PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

IORA_PYRAB

Accession

Primary (citable) accession number: Q9UZ57

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	November 4, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)