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Q9UZ37

- RIBL_PYRAB

UniProt

Q9UZ37 - RIBL_PYRAB

Protein

FAD synthase

Gene

ribL

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.UniRule annotation

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 152ATPUniRule annotation
    Nucleotide bindingi19 – 224ATPUniRule annotation
    Nucleotide bindingi98 – 1014ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. FMN adenylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-HAMAP
    2. FMN metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD synthaseUniRule annotation (EC:2.7.7.2UniRule annotation)
    Alternative name(s):
    FMN adenylyltransferaseUniRule annotation
    Flavin adenine dinucleotide synthaseUniRule annotation
    Gene namesi
    Name:ribLUniRule annotation
    Ordered Locus Names:PYRAB13170
    ORF Names:PAB1507
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 148148FAD synthasePRO_0000406279Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272844.PAB1507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UZ37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal FAD synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0615.
    HOGENOMiHOG000284153.
    KOiK14656.
    OMAiIVLGHDQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_02115. FAD_synth_arch.
    InterProiIPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01467. CTP_transf_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UZ37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGNRRIRVV VGGVFDILHV GHIHFLKMAK ELGDELIVIV AHDETVKKRK    50
    GRPPINPAED RAEVLRAIRY VDDVVIGEPG EISLELIKKL KPDVIALGPD 100
    QDFDCRTLKE KLRSIGLKVE VIRLPYLYKE DRAKTSKIIK RITEIFCD 148
    Length:148
    Mass (Da):16,833
    Last modified:May 1, 2000 - v1
    Checksum:i262B17E43AE43E0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248287 Genomic DNA. Translation: CAB50222.1.
    HE613800 Genomic DNA. Translation: CCE70758.1.
    PIRiA75041.
    RefSeqiNP_126992.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB50222; CAB50222; PAB1507.
    GeneIDi1496704.
    KEGGipab:PAB1507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248287 Genomic DNA. Translation: CAB50222.1 .
    HE613800 Genomic DNA. Translation: CCE70758.1 .
    PIRi A75041.
    RefSeqi NP_126992.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9UZ37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB1507.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50222 ; CAB50222 ; PAB1507 .
    GeneIDi 1496704.
    KEGGi pab:PAB1507.

    Phylogenomic databases

    eggNOGi COG0615.
    HOGENOMi HOG000284153.
    KOi K14656.
    OMAi IVLGHDQ.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_02115. FAD_synth_arch.
    InterProi IPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01467. CTP_transf_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiRIBL_PYRAB
    AccessioniPrimary (citable) accession number: Q9UZ37
    Secondary accession number(s): G8ZHC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3