Q9UZ37 (RIBL_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FAD synthase
EC=2.7.7.2

Alternative name(s):
FMN adenylyltransferase
Flavin adenine dinucleotide synthase

Gene names

Name:	ribL
Ordered Locus Names:	PYRAB13170
ORF Names:	PAB1507

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme By similarity. HAMAP-Rule MF_02115
Catalytic activity	ATP + FMN = diphosphate + FAD. HAMAP-Rule MF_02115
Cofactor	Divalent metal cations By similarity.
Pathway	Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. HAMAP-Rule MF_02115
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the archaeal FAD synthase family.

Ontologies

Keywords
Ligand	ATP-binding FAD FMN Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	FAD biosynthetic process Inferred from electronic annotation. Source: HAMAP FMN metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP FMN adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	FAD synthase HAMAP-Rule MF_02115		PRO_0000406279
Regions
	Nucleotide binding	14 – 15	2	ATP By similarity
	Nucleotide binding	19 – 22	4	ATP By similarity
	Nucleotide binding	98 – 101	4	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UZ37 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 262B17E43AE43E0D	FASTA	148	16,833
	10 20 30 40 50 60 MAGNRRIRVV VGGVFDILHV GHIHFLKMAK ELGDELIVIV AHDETVKKRK GRPPINPAED 70 80 90 100 110 120 RAEVLRAIRY VDDVVIGEPG EISLELIKKL KPDVIALGPD QDFDCRTLKE KLRSIGLKVE 130 140 VIRLPYLYKE DRAKTSKIIK RITEIFCD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248287 Genomic DNA. Translation: CAB50222.1. HE613800 Genomic DNA. Translation: CCE70758.1.
PIR	A75041.
RefSeq	NP_126992.1. NC_000868.1.
3D structure databases
HSSP	HSSP built from PDB template 1COZ based on UniProtKB P27623.
ProteinModelPortal	Q9UZ37.
ModBase	Search...
Protein-protein interaction databases
STRING	272844.PAB1507.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB50222; CAB50222; PAB1507.
GeneID	1496704.
KEGG	pab:PAB1507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0615.
HOGENOM	HOG000284153.
KO	K14656.
OMA	VAHDETV.
ProtClustDB	CLSK253517.
Enzyme and pathway databases
UniPathway	UPA00277; UER00407.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_02115. FAD_synth_arch.
InterPro	IPR004821. Cyt_trans-like. IPR024902. FAD_synth_RibL. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIBL_PYRAB

Accession

Primary (citable) accession number: Q9UZ37
Secondary accession number(s): G8ZHC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program