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Q9UZ35

- PYRF_PYRAB

UniProt

Q9UZ35 - PYRF_PYRAB

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71SubstrateUniRule annotation
Binding sitei29 – 291SubstrateUniRule annotation
Active sitei59 – 591Proton donorUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation
Binding sitei186 – 1861SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:PYRAB13190
ORF Names:PAB1505
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Orotidine 5'-phosphate decarboxylasePRO_0000134614Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB1505.

Structurei

3D structure databases

ProteinModelPortaliQ9UZ35.
SMRiQ9UZ35. Positions 1-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 6610Substrate bindingUniRule annotation
Regioni162 – 17211Substrate bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226069.
KOiK01591.
OMAiTEMSHPG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_A. OMPdecase_type1_A.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UZ35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVLALDVYD EDRALKIAEE TKDYVAMIKV NWPLIIGSGL DIIRKLKDRT
60 70 80 90 100
GLKIIADLKL ADIPNTNKLI ARKVYEAGAD YIIVHPFVGR DSVEAVNELG
110 120 130 140 150
EIILVVEMSH PGALEFINPL TDKFIELAND VEPFGVIAPG TRPERVKYIR
160 170 180 190 200
ERLKEGVKIL TPGIGAQGGK AKEAIEAGAD YVIVGRSIYN APNPREAARE

IYDEIRGE
Length:208
Mass (Da):22,991
Last modified:May 1, 2000 - v1
Checksum:iB993BF06CD61A9BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248287 Genomic DNA. Translation: CAB50224.1.
HE613800 Genomic DNA. Translation: CCE70760.1.
PIRiC75041.
RefSeqiNP_126994.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50224; CAB50224; PAB1505.
GeneIDi1496706.
KEGGipab:PAB1505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248287 Genomic DNA. Translation: CAB50224.1 .
HE613800 Genomic DNA. Translation: CCE70760.1 .
PIRi C75041.
RefSeqi NP_126994.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9UZ35.
SMRi Q9UZ35. Positions 1-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB1505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB50224 ; CAB50224 ; PAB1505 .
GeneIDi 1496706.
KEGGi pab:PAB1505.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226069.
KOi K01591.
OMAi TEMSHPG.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_A. OMPdecase_type1_A.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiPYRF_PYRAB
AccessioniPrimary (citable) accession number: Q9UZ35
Secondary accession number(s): G8ZHC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3