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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7SubstrateUniRule annotation1
Binding sitei29SubstrateUniRule annotation1
Active sitei59Proton donorUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei185Substrate; via amide nitrogenUniRule annotation1
Binding sitei186SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1448-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:PYRAB13190
ORF Names:PAB1505
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346141 – 208Orotidine 5'-phosphate decarboxylaseAdd BLAST208

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB1505

Structurei

3D structure databases

ProteinModelPortaliQ9UZ35
SMRiQ9UZ35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 66Substrate bindingUniRule annotation10
Regioni162 – 172Substrate bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00081 Archaea
COG0284 LUCA
HOGENOMiHOG000226069
KOiK01591
OMAiEMSHPGA
OrthoDBiPOG093Z0B4G

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_A OMPdecase_type1_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UZ35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVLALDVYD EDRALKIAEE TKDYVAMIKV NWPLIIGSGL DIIRKLKDRT
60 70 80 90 100
GLKIIADLKL ADIPNTNKLI ARKVYEAGAD YIIVHPFVGR DSVEAVNELG
110 120 130 140 150
EIILVVEMSH PGALEFINPL TDKFIELAND VEPFGVIAPG TRPERVKYIR
160 170 180 190 200
ERLKEGVKIL TPGIGAQGGK AKEAIEAGAD YVIVGRSIYN APNPREAARE

IYDEIRGE
Length:208
Mass (Da):22,991
Last modified:May 1, 2000 - v1
Checksum:iB993BF06CD61A9BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248287 Genomic DNA Translation: CAB50224.1
HE613800 Genomic DNA Translation: CCE70760.1
PIRiC75041
RefSeqiWP_010868434.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB50224; CAB50224; PAB1505
GeneIDi1496706
KEGGipab:PAB1505
PATRICifig|272844.11.peg.1403

Similar proteinsi

Entry informationi

Entry nameiPYRF_PYRAB
AccessioniPrimary (citable) accession number: Q9UZ35
Secondary accession number(s): G8ZHC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health