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Q9UZ14

- SYT_PYRAB

UniProt

Q9UZ14 - SYT_PYRAB

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Protein
Threonine--tRNA ligase
Gene
thrS, PYRAB13430, PAB1490
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi298 – 2981Zinc; catalytic By similarity
Metal bindingi350 – 3501Zinc; catalytic By similarity
Metal bindingi474 – 4741Zinc; catalytic By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. threonine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligase (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Name:thrS
Ordered Locus Names:PYRAB13430
ORF Names:PAB1490
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625Threonine--tRNA ligaseUniRule annotation
PRO_0000101107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1490.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 2221
Helixi28 – 303
Beta strandi31 – 4414
Helixi47 – 515
Helixi53 – 7119
Beta strandi75 – 806
Helixi82 – 843
Beta strandi86 – 883
Helixi91 – 10717
Beta strandi111 – 1144
Beta strandi117 – 12711
Beta strandi133 – 1386
Helixi142 – 1443

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y2QX-ray1.95A1-143[»]
2HKZX-ray2.10A1-143[»]
2HL0X-ray1.86A1-143[»]
2HL1X-ray2.25A/B1-147[»]
2HL2X-ray2.60A/B1-143[»]
3PD2X-ray1.86A/B1-147[»]
3PD3X-ray1.86A/B1-147[»]
3PD4X-ray2.40A/B1-147[»]
3PD5X-ray2.29A/B1-147[»]
ProteinModelPortaliQ9UZ14.
SMRiQ9UZ14. Positions 1-147.

Miscellaneous databases

EvolutionaryTraceiQ9UZ14.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni206 – 505300CatalyticUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0441.
HOGENOMiHOG000073571.
KOiK01868.
OMAiRQYRFRQ.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002320. Thr-tRNA-ligase_IIa.
IPR015011. Threonyl-tRNA_syn_edit_dom_arc.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF08915. tRNA-Thr_ED. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
ProDomiPD016189. tRNA-Thr_ED_arc. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UZ14-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLLIHSDY IEYEVKDKAL KNPEPISEDM KRGRMEEVLV AFISVEKVDE    50
KNPEEVSLKA IEEISKVAEQ VKAENVFVYP FAHLSSELAK PSVAMDILNR 100
VYQGLKERGF NVGKAPFGYY KAFKISCKGH PLAELSRTIV PEEARVEEVP 150
EALRKEEEEL VSYWYILTPE GELIEVDKFD FTGYENLRKF VNYEIAKNRI 200
AEKEPPHVKL MLEHELVDYE PGSDPGNLRY YPKGRLIKSL LEQYVTEKVI 250
EYGAMEVETP IMYDFEHPAL EKYLNRFPAR QYIVLSGDKR YFLRFAACFG 300
QFMIKKDAII SYRNLPLRMY ELTRYSFRRE KRGELSGLRR LRAFTMPDMH 350
TLAKDIEQAK EEFKKQFKLS MEVLEGVGLT PEDYEVAIRF TEDFWKEHKD 400
FIVELVKLIG KPVLIEMWKQ RFFYFILKFE FNFVDNLDKA AALSTVQIDV 450
ENAERFGITY YDENGEEKYP LILHCSPSGA IERVMYAILE KQAKLMNEGK 500
KPMFPLWLSP IQVRVIPVSE EYLDYALYVA GKLEGAKIRV DVDDEDERLN 550
KKIRRAEKEW IPYIVVVGAR EKENGTITVR RREDGKQYET RIEELIKEIK 600
EKTEGFPYKP RPLPLLLSKR PKFRG 625
Length:625
Mass (Da):73,372
Last modified:May 1, 2000 - v1
Checksum:iAF8E48AAE789124F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248287 Genomic DNA. Translation: CAB50248.1.
HE613800 Genomic DNA. Translation: CCE70785.1.
PIRiC75044.
RefSeqiNP_127018.1. NC_000868.1.
WP_010868458.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50248; CAB50248; PAB1490.
GeneIDi1496731.
KEGGipab:PAB1490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248287 Genomic DNA. Translation: CAB50248.1 .
HE613800 Genomic DNA. Translation: CCE70785.1 .
PIRi C75044.
RefSeqi NP_127018.1. NC_000868.1.
WP_010868458.1. NC_000868.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Y2Q X-ray 1.95 A 1-143 [» ]
2HKZ X-ray 2.10 A 1-143 [» ]
2HL0 X-ray 1.86 A 1-143 [» ]
2HL1 X-ray 2.25 A/B 1-147 [» ]
2HL2 X-ray 2.60 A/B 1-143 [» ]
3PD2 X-ray 1.86 A/B 1-147 [» ]
3PD3 X-ray 1.86 A/B 1-147 [» ]
3PD4 X-ray 2.40 A/B 1-147 [» ]
3PD5 X-ray 2.29 A/B 1-147 [» ]
ProteinModelPortali Q9UZ14.
SMRi Q9UZ14. Positions 1-147.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272844.PAB1490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB50248 ; CAB50248 ; PAB1490 .
GeneIDi 1496731.
KEGGi pab:PAB1490.

Phylogenomic databases

eggNOGi COG0441.
HOGENOMi HOG000073571.
KOi K01868.
OMAi RQYRFRQ.

Miscellaneous databases

EvolutionaryTracei Q9UZ14.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00184. Thr_tRNA_synth.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002320. Thr-tRNA-ligase_IIa.
IPR015011. Threonyl-tRNA_syn_edit_dom_arc.
[Graphical view ]
Pfami PF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF08915. tRNA-Thr_ED. 1 hit.
[Graphical view ]
PRINTSi PR01047. TRNASYNTHTHR.
ProDomi PD016189. tRNA-Thr_ED_arc. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00418. thrS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiSYT_PYRAB
AccessioniPrimary (citable) accession number: Q9UZ14
Secondary accession number(s): G8ZHE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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