Reviewed, UniProtKB/Swiss-Prot Q9UYZ2 (VORB_PYRAB)

Names and origin

Protein names

Recommended name:
    Ketoisovalerate oxidoreductase subunit vorB
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase beta chain
    2-oxoisovalerate ferredoxin reductase subunit beta

Gene names

Name:	vorB
Ordered Locus Names:	PYRAB13650
ORF Names:	PAB1473

Organism

Pyrococcus abyssi [Complete proteome] [HAMAP]

Taxonomic identifier

29292 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain By similarity.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ketoisovalerate oxidoreductase subunit vorB		PRO_0000099956

Sequences

	Sequence		Length	Mass (Da)
	Q9UYZ2-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1EBE2609519DAC30	FASTA	311	34,759
	10 20 30 40 50 60 MEVPEDVKRR LTLPFEENFF AGHTACQGCG ASLGLRYVLK AYGRKTILVI PACCSTIIAG 70 80 90 100 110 120 PWPYSALNAN LFHTAFETTG AVISGIEAAL KALGYKVKGE DGIMVVGWAG DGGTADIGLQ 130 140 150 160 170 180 ALSGFLERGH DALYIMYDNE AYMNTGIQRS SSTPYGAWTT NTPGGKRHFL EKRHKKKVID 190 200 210 220 230 240 IVIAHRIPYA ATASVAYPED FLRKLKKAQK IPGPSFIQLF APCPTGWRAP TDKTIEIARL 250 260 270 280 290 300 AVQTAYFPLF EYENGKYKIN MPNPKKEPKP IEEFLKLQGR FKYMTKEDIE VLQKWVLEEW 310 ERLKKLAEVF G

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248287 Genomic DNA. Translation: CAB50270.1.
PIR	A75047.
RefSeq	NP_127040.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1496754.
KEGG	pab:PAB1473.
NMPDR	fig|272844.1.peg.1447.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG313203.
OMA	PACCSTI.
Enzyme and pathway databases
BioCyc	PABY272844:PAB1473-MONOMER.
BRENDA	1.2.7.7. 262861.
Family and domain databases
InterPro	IPR011766. TPP_enzyme_bd_C. [Graphical view]
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORB_PYRAB

Accession

Primary (citable) accession number: Q9UYZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)