Reviewed, UniProtKB/Swiss-Prot Q9UYZ1 (VORA_PYRAB)

Names and origin

Protein names

Recommended name:
    Ketoisovalerate oxidoreductase subunit vorA
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase alpha chain
    2-oxoisovalerate ferredoxin reductase subunit alpha

Gene names

Name:	vorA
Ordered Locus Names:	PYRAB13660
ORF Names:	PAB1472

Organism

Pyrococcus abyssi [Complete proteome] [HAMAP]

Taxonomic identifier

29292 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Ketoisovalerate oxidoreductase subunit vorA		PRO_0000099951

Sequences

	Sequence		Length	Mass (Da)
	Q9UYZ1-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: DF760EDF08CB6823	FASTA	395	44,230
	10 20 30 40 50 60 MVEYKPIKKV VSGNYAAAYA VLHARVQVVA AYPITPQTSI IEKIAEFIAN GEADIQYIPV 70 80 90 100 110 120 ESEHSAMAAC IGASATGARV FTATSAQGLA LMHEMLHWAA GARLPIVMVD VNRAMAPPWS 130 140 150 160 170 180 VWDDQTDSLS QRDTGWMQFY AENNQEVYDG VLMAFKVAET VNVPAMVVES AFILSHTYEI 190 200 210 220 230 240 VNMIPQELVD EFLPPRKPLY SLADFENPIA VGALATPADY YEFRYKLARA HEEAKKVIKD 250 260 270 280 290 300 VGREFGERFG RDYSEMIEKA YIDDADFVFM GMGSLMGTVK EAVELLRKQG YKVGYAKVRW 310 320 330 340 350 360 FRPFPREELL EIAESVKGIA VLDRNFSFGQ EGILFTEAKG ALYNNGARPI MKNYIVGLGG 370 380 390 RDFTVSDVKA IAEDMKKVIE SGKLDREVEW YHLKR

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248287 Genomic DNA. Translation: CAB50271.1.
PIR	B75047.
RefSeq	NP_127041.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1496755.
KEGG	pab:PAB1472.
NMPDR	fig|272844.1.peg.1448.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG313202.
OMA	NGEADIQ.
Enzyme and pathway databases
BioCyc	PABY272844:PAB1472-MONOMER.
BRENDA	1.2.7.7. 262861.
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF01855. POR_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORA_PYRAB

Accession

Primary (citable) accession number: Q9UYZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)