Reviewed, UniProtKB/Swiss-Prot Q9UYY9 (PORC_PYRAB)

Names and origin

Protein names

Recommended name:
    Pyruvate/ketoisovalerate oxidoreductases common subunit gamma
Including the following 2 domains:
    1- Recommended name:
            Pyruvate synthase subunit porC
              EC=1.2.7.1
        Alternative name(s):
            Pyruvate oxidoreductase gamma chain
              Short name=POR
            Pyruvic-ferredoxin oxidoreductase subunit gamma
    2- Recommended name:
            Ketoisovalerate oxidoreductase subunit vorC
                Short name=VOR
              EC=1.2.7.7
        Alternative name(s):
            2-oxoisovalerate oxidoreductase gamma chain
            2-oxoisovalerate ferredoxin reductase subunit gamma

Gene names

Name:	porG
Ordered Locus Names:	PYRAB13680
ORF Names:	PAB1470

Organism

Pyrococcus abyssi [Complete proteome] [HAMAP]

Taxonomic identifier

29292 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Pyruvate/ketoisovalerate oxidoreductases common subunit gamma		PRO_0000099913

Sequences

	Sequence		Length	Mass (Da)
	Q9UYY9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2387E6FE6C6A27EC	FASTA	185	20,023
	10 20 30 40 50 60 MIEIRFHGRG GQGAVTAANI LAEAAFIEGK YVQAFPFFGV ERRGAPVTAF TRIDEKPIRI 70 80 90 100 110 120 KTQIYEPDVV VVLDPSLLET VDVTAGLKED GIVIVNTEKS KEEVLEKLKR KPKKLALVDA 130 140 150 160 170 180 TTIALETLGL PITNTAILGA VAKATGLVKI ESVETAIKDT FSGELGEKNA KAAREAFEKT QIFEV

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248287 Genomic DNA. Translation: CAB50273.1.
PIR	D75047.
RefSeq	NP_127043.1.
3D structure databases
SMR	Q9UYY9. Positions 1-183.
ModBase	Search...
Genome annotation databases
GeneID	1496757.
KEGG	pab:PAB1470.
NMPDR	fig|272844.1.peg.1450.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553299.
OMA	KEIRIHG.
Enzyme and pathway databases
BioCyc	PABY272844:PAB1470-MONOMER.
BRENDA	1.2.7.1. 262861. 1.2.7.7. 262861.
Family and domain databases
InterPro	IPR011894. PorC_KorC. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
Pfam	PF01558. POR. 1 hit. [Graphical view]
TIGRFAMs	TIGR02175. PorC_KorC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PORC_PYRAB

Accession

Primary (citable) accession number: Q9UYY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)