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Reviewed, UniProtKB/Swiss-Prot Q9UYU5 (CDR_PYRAB)

Last modified June 16, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Coenzyme A disulfide reductase
      Short name=CoA-disulfide reductase
      Short name=CoADR
    EC=1.8.1.14
Gene names
Ordered Locus Names: PYRAB14120
ORF Names: PAB0936
OrganismPyrococcus abyssi [Complete proteome] [HAMAP]
Taxonomic identifier29292 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

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Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

2 CoA + NAD(P)+ = CoA-disulfide + NAD(P)H.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Coenzyme A disulfide reductase
PRO_0000184697

Regions

Nucleotide binding14 – 3926FAD By similarity
Nucleotide binding155 – 17016NADP By similarity
Nucleotide binding274 – 28411FAD By similarity

Sites

Active site491Nucleophile By similarity
Active site491Redox-active By similarity
Binding site211Substrate
Binding site251Substrate
Binding site281Substrate By similarity
Binding site451Substrate By similarity
Binding site761Substrate
Binding site4261FAD; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9UYU5-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0B7048662F50BD72

FASTA44649,181
        10         20         30         40         50         60 
MRVVKVKKTV VIIGGGAAGM SAASRVKRLK PEWDVKVFEA TEWVSHAPCG IPYVVEGISP 

        70         80         90        100        110        120 
TEKLMHYPPE VFIKKRGIDL HLNAEVIEVD TGYVRVREKD GEKSYEWDYL VFANGASPQV 

       130        140        150        160        170        180 
PAIEGVDLKG VFTADLPPDA VAIREYMEKN RVEDVVIVGG GYIGLEMAEA FVAQGKRVTM 

       190        200        210        220        230        240 
IVRGERILRR SFDKEVTDII EEKLKQHVNL RLQEIVLRIE GKDRVEKVVT DAGEYRADLV 

       250        260        270        280        290        300 
ILATGIKPNI ELARQLGVRI GETGAIWTNE KMQTSVENVY AAGDVAETKH VITGRRVWVP 

       310        320        330        340        350        360 
LAPPGNKMGY VAGSNIAGKE IHFPGVLGTT VTKFLDVEIG KTGLTETEAL KEGYDIRTAF 

       370        380        390        400        410        420 
IKASTRPHYY PGGKEIWLKG VVDNETNRLL GVQAVGAEIL PRIDAAAAML MANFTTKDAF 

       430        440 
FTDLAYAPPF APVWDPLVVL ARVLKF

« Hide

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References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.

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Cross-references

Sequence databases

AJ248287 Genomic DNA. Translation: CAB50317.1.
PIRH75052.
RefSeqNP_127087.1.

3D structure databases

HSSPHSSP built from PDB template 1NHP based on UniProtKB P37062.
ModBaseSearch...

Genome annotation databases

GeneID1496802.
GenomeReviewsGene locus PYRAB14120 in contig AL096836_GR.
KEGGpab:PAB0936.
NMPDRfig|272844.1.peg.1495.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9UYU5.
OMAQ9UYU5. DVAETKH.

Enzyme and pathway databases

BioCycPABY272844:PAB0936-MON.
BRENDA1.8.1.14. 262861.

Family and domain databases

InterProIPR017758. CoA_disulphide_reductase.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR001327. Pyr_OxRdtase_NAD_bd.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
ProDomPD000139. FAD_pyr_redox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03385. CoA_CoA_reduc. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameCDR_PYRAB
AccessionPrimary (citable) accession number: Q9UYU5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents