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Protein

GPN-loop GTPase PAB0955

Gene

PYRAB14380

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Small GTPase that may be involved in genome maintenance. Has weak intrinsic GTPase activity but displays no ATPase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei67Stabilizes the phosphate intermediate; shared with dimeric partner1 Publication1
Binding sitei224GTP; via amide nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15GTP1 Publication6
Nucleotide bindingi165 – 168GTP1 Publication4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GPN-loop GTPase PAB09551 Publication (EC:3.6.5.-1 Publication)
Gene namesi
Ordered Locus Names:PYRAB14380Imported
ORF Names:PAB0955Imported
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004312971 – 248GPN-loop GTPase PAB0955Add BLAST248

Interactioni

Subunit structurei

Homodimer (PubMed:16510996). Interacts with DNA topoisomerase VI subunit B (top6B), DNA primase DnaG and RF-C (PubMed:17468740).2 Publications

Protein-protein interaction databases

MINTiMINT-4791347.
STRINGi272844.PAB0955.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 6Combined sources6
Helixi13 – 24Combined sources12
Turni25 – 27Combined sources3
Beta strandi30 – 34Combined sources5
Beta strandi47 – 49Combined sources3
Helixi50 – 52Combined sources3
Helixi56 – 60Combined sources5
Turni61 – 63Combined sources3
Helixi66 – 78Combined sources13
Helixi81 – 94Combined sources14
Beta strandi96 – 101Combined sources6
Helixi106 – 111Combined sources6
Helixi113 – 120Combined sources8
Beta strandi122 – 124Combined sources3
Beta strandi126 – 131Combined sources6
Helixi133 – 135Combined sources3
Helixi139 – 156Combined sources18
Beta strandi160 – 164Combined sources5
Helixi167 – 169Combined sources3
Helixi172 – 183Combined sources12
Helixi185 – 194Combined sources10
Helixi198 – 213Combined sources16
Turni224 – 226Combined sources3
Helixi230 – 244Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YR6X-ray2.15A1-248[»]
1YR7X-ray2.08A1-248[»]
1YR8X-ray2.40A1-248[»]
1YR9X-ray2.80A1-248[»]
1YRAX-ray2.30A/B1-248[»]
1YRBX-ray1.75A/B1-248[»]
2OXRX-ray2.40A1-248[»]
SMRiQ9UYR9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UYR9.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi65 – 67Gly-Pro-Asn (GPN)-loop; involved in dimer interface1 Publication3

Sequence similaritiesi

Belongs to the GPN-loop GTPase family.Curated

Phylogenomic databases

eggNOGiarCOG01225. Archaea.
COG1100. LUCA.
HOGENOMiHOG000110575.
KOiK06883.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR004130. Gpn.
IPR030228. Gpn3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR21231. PTHR21231. 1 hit.
PTHR21231:SF7. PTHR21231:SF7. 1 hit.
PfamiPF03029. ATP_bind_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UYR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVVFVGTAG SGKTTLTGEF GRYLEDNYKV AYVNLDTGVK ELPYEPSIDV
60 70 80 90 100
REFVTVEEIM REGYGPNGAI VESYDRLMEK FNEYLNKILR LEKENDYVLI
110 120 130 140 150
DTPGQMETFL FHEFGVRLME NLPYPLVVYI SDPEILKKPN DYCFVRFFAL
160 170 180 190 200
LIDLRLGATT IPALNKVDLL SEEEKERHRK YFEDIDYLTA RLKLDPSMQG
210 220 230 240
LMAYKMCSMM TEVLPPVRVL YLSAKTREGF EDLETLAYEH YCTCGDLT
Length:248
Mass (Da):28,697
Last modified:November 26, 2014 - v2
Checksum:iF88FB5473E40B0D3
GO

Sequence cautioni

The sequence CAB50343 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248287 Genomic DNA. Translation: CAB50343.1. Different initiation.
HE613800 Genomic DNA. Translation: CCE70884.1.
PIRiB75056.
RefSeqiWP_048147021.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50343; CAB50343; PAB0955.
GeneIDi1495713.
KEGGipab:PAB0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248287 Genomic DNA. Translation: CAB50343.1. Different initiation.
HE613800 Genomic DNA. Translation: CCE70884.1.
PIRiB75056.
RefSeqiWP_048147021.1. NC_000868.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YR6X-ray2.15A1-248[»]
1YR7X-ray2.08A1-248[»]
1YR8X-ray2.40A1-248[»]
1YR9X-ray2.80A1-248[»]
1YRAX-ray2.30A/B1-248[»]
1YRBX-ray1.75A/B1-248[»]
2OXRX-ray2.40A1-248[»]
SMRiQ9UYR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4791347.
STRINGi272844.PAB0955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50343; CAB50343; PAB0955.
GeneIDi1495713.
KEGGipab:PAB0955.

Phylogenomic databases

eggNOGiarCOG01225. Archaea.
COG1100. LUCA.
HOGENOMiHOG000110575.
KOiK06883.

Miscellaneous databases

EvolutionaryTraceiQ9UYR9.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR004130. Gpn.
IPR030228. Gpn3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR21231. PTHR21231. 1 hit.
PTHR21231:SF7. PTHR21231:SF7. 1 hit.
PfamiPF03029. ATP_bind_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPN_PYRAB
AccessioniPrimary (citable) accession number: Q9UYR9
Secondary accession number(s): G8ZIK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: November 26, 2014
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.