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Reviewed, UniProtKB/Swiss-Prot Q9UYR1 (GYAR_PYRAB)

Last modified February 9, 2010. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glyoxylate reductase
    EC=1.1.1.26
Gene names
Name: gyaR
Ordered Locus Names: PYRAB14460
ORF Names: PAB2374
OrganismPyrococcus abyssi [Complete proteome] [HAMAP]
Taxonomic identifier29292 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

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Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Glycolate + NAD+ = glyoxylate + NADH. HAMAP MF_00776

Subunit structure

Homodimer By similarity. HAMAP MF_00776

Subcellular location

Cytoplasm By similarity HAMAP MF_00776.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD or NADH binding

Inferred from electronic annotation. Source: InterPro

glyoxylate reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Glyoxylate reductase HAMAP MF_00776
PRO_0000075947

Regions

Nucleotide binding159 – 1624NADP By similarity
Nucleotide binding181 – 1833NADP By similarity
Nucleotide binding240 – 2423NADP By similarity
Nucleotide binding289 – 2913NADP By similarity

Sites

Active site2421 By similarity
Active site2711 By similarity
Active site2891Proton donor By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9UYR1-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 32CEA1CB7126A0B4

FASTA33538,270
        10         20         30         40         50         60 
MSKPRVFITR EIPEVGIEML EKEFEVEVWE DEREIPREIL LEKVKDVDAL VTMLSERIDR 

        70         80         90        100        110        120 
EVFERAPRLR IVANYAVGYD NIDVEEATKR GIYVTNTPGV LTDATADLAF ALLLATARHL 

       130        140        150        160        170        180 
VKGDKFTRSG EWKKRGVAWH PKWFLGYDVY GKTIGIIGFG RIGQAIAKRA RGFDMRILYY 

       190        200        210        220        230        240 
SRTRKPEVEK ELNAEFKPLD ELLRESDFVV LAVPLNKETY HMINEERLKM MKRTAILINV 

       250        260        270        280        290        300 
ARGKVIDTKA LIKALKEGWI AGAGLDVYEE EPYYNEELFS LDNVVLTPHI GSATFGAREG 

       310        320        330 
MAKLVAENLI AFKRGEVPPT LVNREVLKVR KPGFQ

« Hide

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References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ248287 Genomic DNA. Translation: CAB50351.1.
PIRB75057.
RefSeqNP_127121.1.

3D structure databases

SMRQ9UYR1. Positions 3-334.
ModBaseSearch...

Genome annotation databases

GeneID1495721.
KEGGpab:PAB2374.
NMPDRfig|272844.1.peg.1531.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG731446.
OMARSGEWKK.

Enzyme and pathway databases

BioCycPABY272844:PAB2374-MONOMER.
BRENDA1.1.1.26. 262861.

Family and domain databases

HAMAPMF_00776. GyaR.
[Tree]
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGYAR_PYRAB
AccessionPrimary (citable) accession number: Q9UYR1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents