Q9UYQ9 (PCP_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrrolidone-carboxylate peptidase
EC=3.4.19.3

Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name=PGP-I
Short name=Pyrase

Gene names

Name:	pcp
Ordered Locus Names:	PYRAB14480
ORF Names:	PAB1419

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes 5-oxoproline from various penultimate amino acid residues except L-proline. HAMAP-Rule MF_00417
Catalytic activity	Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. HAMAP-Rule MF_00417
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm HAMAP-Rule MF_00417.
Sequence similarities	Belongs to the peptidase C15 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW pyroglutamyl-peptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Pyrrolidone-carboxylate peptidase HAMAP-Rule MF_00417		PRO_0000184754
Sites
	Active site	79	1	By similarity
	Active site	142	1	By similarity
	Active site	166	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UYQ9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6F97DB87529D222A	FASTA	200	22,082
	10 20 30 40 50 60 MKVLVTGFEP FGGDDKNPTM EIVKFLDGKE IGGAKVIGRV LPVSFKRARK ELVAILDEIK 70 80 90 100 110 120 PDVTINLGLA PGRTHISVER VAVNIIDARI PDNDGEKPID EPIVENGPAA YFATIPTREI 130 140 150 160 170 180 VEEMKRNNIP AVLSYTAGTY LCNFVMYLTL HHSATKGYPR KAGFIHVPYT PDQVIEKKNT 190 200 PSMSLELEIK GVEIAIRKSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248287 Genomic DNA. Translation: CAB50353.1. HE613800 Genomic DNA. Translation: CCE70894.1.
PIR	D75057.
RefSeq	NP_127123.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9UYQ9.
SMR	Q9UYQ9. Positions 1-197.
ModBase	Search...
Protein-protein interaction databases
STRING	272844.PAB1419.
Protein family/group databases
MEROPS	C15.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB50353; CAB50353; PAB1419.
GeneID	1495723.
KEGG	pab:PAB1419.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2039.
HOGENOM	HOG000242641.
KO	K01304.
OMA	AYFTQLP.
ProtClustDB	PRK13194.
Family and domain databases
Gene3D	3.40.630.20. 1 hit.
HAMAP	MF_00417. Pyrrolid_peptidase.
InterPro	IPR000816. Peptidase_C15. IPR016125. Peptidase_C15-like. [Graphical view]
PANTHER	PTHR23402. PTHR23402. 1 hit.
Pfam	PF01470. Peptidase_C15. 1 hit. [Graphical view]
PIRSF	PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTS	PR00706. PYROGLUPTASE.
SUPFAM	SSF53182. Peptidase_C15-like. 1 hit.
TIGRFAMs	TIGR00504. pyro_pdase. 1 hit.
PROSITE	PS01334. PYRASE_CYS. 1 hit. PS01333. PYRASE_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PCP_PYRAB

Accession

Primary (citable) accession number: Q9UYQ9
Secondary accession number(s): G8ZIL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program