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Q9UYQ9

- PCP_PYRAB

UniProt

Q9UYQ9 - PCP_PYRAB

Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    • Comment

    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791By similarity
    Active sitei142 – 1421By similarity
    Active sitei166 – 1661By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:PYRAB14480
    ORF Names:PAB1419
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Pyrrolidone-carboxylate peptidasePRO_0000184754Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi272844.PAB1419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UYQ9.
    SMRiQ9UYQ9. Positions 1-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.Curated

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiKPNTPSM.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UYQ9-1 [UniParc]FASTAAdd to Basket

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    MKVLVTGFEP FGGDDKNPTM EIVKFLDGKE IGGAKVIGRV LPVSFKRARK    50
    ELVAILDEIK PDVTINLGLA PGRTHISVER VAVNIIDARI PDNDGEKPID 100
    EPIVENGPAA YFATIPTREI VEEMKRNNIP AVLSYTAGTY LCNFVMYLTL 150
    HHSATKGYPR KAGFIHVPYT PDQVIEKKNT PSMSLELEIK GVEIAIRKSL 200
    Length:200
    Mass (Da):22,082
    Last modified:May 1, 2000 - v1
    Checksum:i6F97DB87529D222A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248287 Genomic DNA. Translation: CAB50353.1.
    HE613800 Genomic DNA. Translation: CCE70894.1.
    PIRiD75057.
    RefSeqiNP_127123.1. NC_000868.1.
    WP_010868563.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB50353; CAB50353; PAB1419.
    GeneIDi1495723.
    KEGGipab:PAB1419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248287 Genomic DNA. Translation: CAB50353.1 .
    HE613800 Genomic DNA. Translation: CCE70894.1 .
    PIRi D75057.
    RefSeqi NP_127123.1. NC_000868.1.
    WP_010868563.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9UYQ9.
    SMRi Q9UYQ9. Positions 1-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB1419.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50353 ; CAB50353 ; PAB1419 .
    GeneIDi 1495723.
    KEGGi pab:PAB1419.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi KPNTPSM.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiPCP_PYRAB
    AccessioniPrimary (citable) accession number: Q9UYQ9
    Secondary accession number(s): G8ZIL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3