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Reviewed, UniProtKB/Swiss-Prot Q9UYQ3 (GLKA_PYRAB)

Last modified November 3, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADP-dependent glucokinase
      Short name=ADPGK
      Short name=ADP-GK
    EC=2.7.1.147
Gene names
Name: glkA
Ordered Locus Names: PYRAB14540
ORF Names: PAB0967
OrganismPyrococcus abyssi [Complete proteome] [HAMAP]
Taxonomic identifier29292 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

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Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor By similarity.

Catalytic activity

ADP + D-glucose = AMP + D-glucose 6-phosphate. HAMAP MF_00809

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Carbohydrate degradation; glycolysis. HAMAP MF_00809

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the ADP-dependent glucokinase family.

Contains 1 ADPK (ADP-dependent kinase) domain.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
Glycolysis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionADP-specific glucokinase activity

Inferred from electronic annotation. Source: EC

glucokinase activity

Inferred from electronic annotation. Source: HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452ADP-dependent glucokinase HAMAP MF_00809
PRO_0000184771

Regions

Domain1 – 452452ADPK
Nucleotide binding339 – 3413ADP By similarity
Nucleotide binding435 – 4395ADP By similarity

Sites

Active site4371Proton acceptor By similarity
Metal binding2641Magnesium By similarity
Metal binding2931Magnesium By similarity
Metal binding4371Magnesium By similarity
Binding site291Glucose By similarity
Binding site331Glucose By similarity
Binding site871Glucose By similarity
Binding site1121Glucose By similarity
Binding site1741Glucose By similarity
Binding site1951Glucose By similarity
Binding site2901ADP By similarity
Binding site3391ADP By similarity
Binding site3401ADP; via carbonyl oxygen By similarity
Binding site4261ADP; via carbonyl oxygen By similarity
Binding site4371ADP By similarity
Binding site4371Glucose By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9UYQ3-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4212E6CE9D4FC4E9

FASTA45251,572
        10         20         30         40         50         60 
MSWDEMYRDA YERVLNSIGK IKGVMLAYNT NIDAIKYLKR EDLERRIEEA GKDEVLRYSD 

        70         80         90        100        110        120 
ELPKKINTIQ QLLGSILWSV KRGKAAELLV EDREVRNYMR QWGWDELRMG GQVGIMANLL 

       130        140        150        160        170        180 
GGVYGIPVIA HVPQISKLQA SLFLDGPIYV PTFEEGLKLV HPRNFEGNEE DCIHYIYEFP 

       190        200        210        220        230        240 
RGFKVLNFTA PRENRFIGAA DDYNPRLYIR KEWVERFEEI AERAELAIVS GLHSLTEETY 

       250        260        270        280        290        300 
REPIKVVREH LKVLKDLNIK THLEFAFTAD EKVRREILGL LSLVYSVGLN EVELASVLEI 

       310        320        330        340        350        360 
MNERELADRI LAKDPADPVA VIEGLMKLIE EGVERIHFHT YGYYLAITKY RGEHVRDALL 

       370        380        390        400        410        420 
FSALAAATKA MLGNIEKLDD LRKGLEVPIG RQGLEVYEVV KREFNVEKGI GEVGDYQIAF 

       430        440        450 
VPTKIVEKPK STVGIGDTIS SSAFVSEFSL SS

« Hide

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References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.

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Cross-references

Sequence databases

AJ248287 Genomic DNA. Translation: CAB50359.1.
PIRB75058.
RefSeqNP_127129.1.

3D structure databases

HSSPHSSP built from PDB template 1L2L based on UniProtKB O58328.
SMRQ9UYQ3. Positions 3-450.
ModBaseSearch...

Genome annotation databases

GeneID1495729.
GenomeReviewsGene locus PYRAB14540 in contig AL096836_GR.
KEGGpab:PAB0967.
NMPDRfig|272844.1.peg.1539.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9UYQ3.
OMAGIMANLL.

Enzyme and pathway databases

BioCycPABY272844:PAB0967-MON.
BRENDA2.7.1.147. 262861.

Family and domain databases

HAMAPMF_00809.
[Tree]
InterProIPR007666. ADP_PFK/GK.
IPR015990. ADP_PFK/GK_arc.
[Graphical view]
PANTHERPTHR21208. ADP_PFK/GK. 1 hit.
PfamPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
PIRSFPIRSF015883. ADP-Pfk_glckin. 1 hit.
PROSITEPS51255. ADPK. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLKA_PYRAB
AccessionPrimary (citable) accession number: Q9UYQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents