ID   Q9UYH3_PYRAB            Unreviewed;       313 AA.
AC   Q9UYH3;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 135.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=PAB1013 {ECO:0000313|EMBL:CAB50439.1};
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844 {ECO:0000313|EMBL:CAB50439.1, ECO:0000313|Proteomes:UP000000810};
RN   [1] {ECO:0000313|EMBL:CAB50439.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Orsay {ECO:0000313|EMBL:CAB50439.1};
RA   Genoscope;
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAB50439.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Orsay {ECO:0000313|EMBL:CAB50439.1};
RX   PubMed=10736225; DOI=10.1006/jmbi.2000.3593;
RA   Gaspin C., Cavaille J., Erauso G.;
RT   "Archaeal homologs of eukaryotic methylation guide small nucleolar RNAs:
RT   lessons from the Pyrococcus genomes.";
RL   J. Mol. Biol. 297:895-906(2000).
RN   [3] {ECO:0000313|EMBL:CAB50439.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Orsay {ECO:0000313|EMBL:CAB50439.1};
RX   PubMed=11381026; DOI=10.1101/gr.GR1653R;
RA   Lecompte O., Ripp R., Puzos-Barbe V., Duprat S., Heilig R., Dietrich J.,
RA   Thierry J.C., Poch O.;
RT   "Genome evolution at the genus level: comparison of three complete genomes
RT   of hyperthermophilic archaea.";
RL   Genome Res. 11:981-993(2001).
RN   [4] {ECO:0000313|EMBL:CAB50439.1, ECO:0000313|Proteomes:UP000000810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay {ECO:0000313|Proteomes:UP000000810}, and Orsay
RC   {ECO:0000313|EMBL:CAB50439.1};
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G., Barbe V., Flament D., Galperin M., Heilig R., Ripp R.,
RA   Lecompte O., Prieur D., Poch O., Quellerou J., Thierry J.C.,
RA   Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [5] {ECO:0000313|EMBL:CCE70988.1, ECO:0000313|Proteomes:UP000009139}
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 {ECO:0000313|EMBL:CCE70988.1}, and GE5 / Orsay
RC   {ECO:0000313|Proteomes:UP000009139};
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. RIO-type Ser/Thr
CC       kinase family. {ECO:0000256|ARBA:ARBA00009196}.
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DR   EMBL; AJ248287; CAB50439.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70988.1; -; Genomic_DNA.
DR   PIR; B75068; B75068.
DR   RefSeq; WP_010868652.1; NC_000868.1.
DR   AlphaFoldDB; Q9UYH3; -.
DR   STRING; 272844.PAB1013; -.
DR   GeneID; 1495817; -.
DR   KEGG; pab:PAB1013; -.
DR   PATRIC; fig|272844.11.peg.1633; -.
DR   eggNOG; arCOG01181; Archaea.
DR   HOGENOM; CLU_018693_1_0_2; -.
DR   OrthoDB; 50101at2157; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05144; RIO2_C; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR030484; Rio2.
DR   InterPro; IPR015285; RIO2_wHTH_N.
DR   InterPro; IPR000687; RIO_kinase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45852; SER/THR-PROTEIN KINASE RIO2; 1.
DR   PANTHER; PTHR45852:SF1; SERINE_THREONINE-PROTEIN KINASE RIO2; 1.
DR   Pfam; PF01163; RIO1; 1.
DR   Pfam; PF09202; Rio2_N; 1.
DR   SMART; SM00090; RIO; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAB50439.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW   ECO:0000313|EMBL:CAB50439.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          98..313
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   313 AA;  36252 MW;  6E8B6BAFB314B5D7 CRC64;
     MVSKLLALEA YPKLKDIDFR LLRAVELKMR YYKWVPLEEI AKFARMDVES ASYRLGKLDD
     FGLVIRRSDM GYIGYQLTIH GYDALAIRAF AKKGVIEAIS TTQIGVGKDA DVYVAITPSG
     EKVAVKFNRI GERTSARKAF YHSDVFADKH HKSWLYVSRL IAKKEHEALV LLSPFAKVPK
     PIAWNRHAIV MEFINGVELA ELRDTDLTRE EADEILGKVL DEYEKIVKFG IVHGDMSEFN
     VVLTEDNDIL IIDWAQYQSC ANPESLELLK RDITVLLNAF RRRWGVKRNF EEEWKRFYEA
     WLIGRKEISE EQQ
//