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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.By similarity

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei173By similarity1
Active sitei200By similarity1
Active sitei296By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase (EC:3.1.1.61)
Gene namesi
Name:cheB
Ordered Locus Names:PYRAB15550
ORF Names:PAB1331
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580561 – 368Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei604-aspartylphosphateBy similarity1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1331.

Structurei

3D structure databases

ProteinModelPortaliQ9UYF3.
SMRiQ9UYF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 126Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini161 – 354CheB-type methylesteraseAdd BLAST194

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.By similarity

Phylogenomic databases

eggNOGiarCOG02382. Archaea.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG093Z00HE.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UYF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTGRKIRV LVVDDSAFMR KVLKDIINSD PELEVCGEAR DGIEAIEMVQ
60 70 80 90 100
KCRPDVVTLD VEMPRMNGLD ALRVIMKKYP VPVIMISALT QEGAEATIKA
110 120 130 140 150
LEYGAIDFIP KPSSSISINM RELKDEIIAK IKEAAKVPRR FLELRRIRLL
160 170 180 190 200
RVQKAKKVKP SVPARIAVAI AASTGGPQSL LKIFPKFPEN LKAGILLVQH
210 220 230 240 250
MPPGFTRSFA KRLDSVSKID VKEAEEGDVV EEGKAYVAPG DYHMEVTLRG
260 270 280 290 300
GKPVITLNKK PKMHGVRPAA DPMMITAAQV FGRRTVGVVM TGMGRDGAQG
310 320 330 340 350
IVEIKKRGGI TIAQDEKTSI IFGMPKAAIE TGMVDYVVPL EKIPETVVRA
360
VEMIRGGGNL GRHVTIPR
Length:368
Mass (Da):40,313
Last modified:May 1, 2000 - v1
Checksum:i147655F99918D0AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248288 Genomic DNA. Translation: CAB50459.1.
HE613800 Genomic DNA. Translation: CCE71009.1.
PIRiE75002.
RefSeqiWP_010868672.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50459; CAB50459; PAB1331.
GeneIDi1495838.
KEGGipab:PAB1331.
PATRICifig|272844.11.peg.1654.

Similar proteinsi

Entry informationi

Entry nameiCHEB_PYRAB
AccessioniPrimary (citable) accession number: Q9UYF3
Secondary accession number(s): G8ZIX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome