Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (cytidine(56)-2'-O)-methyltransferase

Gene

PYRAB15770

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + cytidine(56) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(56) in tRNA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

  • tRNA methyltransferase activity Source: UniProtKB

GO - Biological processi

  • tRNA nucleoside ribose methylation Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1737-MONOMER
BRENDAi2.1.1.206 5242

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (cytidine(56)-2'-O)-methyltransferase (EC:2.1.1.206)
Alternative name(s):
tRNA ribose 2'-O-methyltransferase aTrm56
Gene namesi
Ordered Locus Names:PYRAB15770
ORF Names:PAB1040
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469331 – 198tRNA (cytidine(56)-2'-O)-methyltransferaseAdd BLAST198

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272844.PAB1040

Structurei

3D structure databases

ProteinModelPortaliQ9UYD1
SMRiQ9UYD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 114S-adenosyl-L-methionine bindingBy similarity5
Regioni128 – 135S-adenosyl-L-methionine bindingBy similarity8

Sequence similaritiesi

Belongs to the aTrm56 family.Curated

Phylogenomic databases

eggNOGiarCOG01857 Archaea
COG1303 LUCA
HOGENOMiHOG000015482
KOiK07254
OMAiVVHLTMY
OrthoDBiPOG093Z0BT8

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
HAMAPiMF_00077 tRNA_methyltr_aTrm56, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029026 tRNA_m1G_MTases_N
IPR002845 tRNA_mtfrase_aTrm56
PANTHERiPTHR42197 PTHR42197, 1 hit
PfamiView protein in Pfam
PF01994 Trm56, 1 hit
PIRSFiPIRSF016123 UCP016123, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016584 DUF127, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UYD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVVLRLGHR PERDKRVTTH VALTARAFGA DGIIIVSEEV DLKVKESVED
60 70 80 90 100
VVERWGGPFF VKFEKSWRKV MKEFDGVKVH LTMYGIHIDD IIDELREKLR
110 120 130 140 150
EGRDFMVIVG AEKVPREVYE LADYNVAIGN QPHSEVAALA VFLDRLLEGK
160 170 180 190
GLRKEFKGAK LKIIPQARGK MVVEVQKDAK QAEASGEGAS RKNGQLPS
Length:198
Mass (Da):22,262
Last modified:May 1, 2000 - v1
Checksum:iD126B48B3A0D5AAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248288 Genomic DNA Translation: CAB50481.1
HE613800 Genomic DNA Translation: CCE71034.1
PIRiC75005
RefSeqiWP_010868694.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB50481; CAB50481; PAB1040
GeneIDi1495863
KEGGipab:PAB1040
PATRICifig|272844.11.peg.1681

Similar proteinsi

Entry informationi

Entry nameiTRM56_PYRAB
AccessioniPrimary (citable) accession number: Q9UYD1
Secondary accession number(s): G8ZJ01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health