Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine synthetase

Gene

glnA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.By similarity

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.By similarity

Cofactori

Mg2+By similarityNote: Binds 2 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi122Magnesium 1By similarity1
Metal bindingi124Magnesium 2By similarity1
Binding sitei172ATPBy similarity1
Metal bindingi177Magnesium 2By similarity1
Metal bindingi184Magnesium 2By similarity1
Binding sitei229L-glutamate; via carbonyl oxygenBy similarity1
Metal bindingi233Magnesium 1; via pros nitrogenBy similarity1
Binding sitei237ATPBy similarity1
Binding sitei283L-glutamateBy similarity1
Binding sitei289L-glutamateBy similarity1
Binding sitei301ATPBy similarity1
Binding sitei301L-glutamateBy similarity1
Binding sitei306ATPBy similarity1
Metal bindingi318Magnesium 1By similarity1
Binding sitei320L-glutamateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi235 – 237ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1774-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetaseBy similarity (EC:6.3.1.2By similarity)
Short name:
GSBy similarity
Alternative name(s):
Glutamate--ammonia ligaseBy similarity
Glutamine synthetase I alphaBy similarity
Short name:
GSI alphaBy similarity
Gene namesi
Name:glnABy similarity
Ordered Locus Names:PYRAB16090
ORF Names:PAB1292
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532081 – 439Glutamine synthetaseAdd BLAST439

Proteomic databases

PRIDEiQ9UY99

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi272844.PAB1292

Structurei

3D structure databases

ProteinModelPortaliQ9UY99
SMRiQ9UY99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.By similarity

Phylogenomic databases

eggNOGiarCOG01909 Archaea
COG0174 LUCA
HOGENOMiHOG000005156
KOiK01915
OMAiIEAAWNT
OrthoDBiPOG093Z00GE

Family and domain databases

Gene3Di3.10.20.70, 1 hit
InterProiView protein in InterPro
IPR008147 Gln_synt_b-grasp
IPR036651 Gln_synt_N
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR008146 Gln_synth_cat_dom
IPR027303 Gln_synth_gly_rich_site
IPR004809 Gln_synth_I
IPR027302 Gln_synth_N_conserv_site
PfamiView protein in Pfam
PF00120 Gln-synt_C, 1 hit
PF03951 Gln-synt_N, 1 hit
SMARTiView protein in SMART
SM01230 Gln-synt_C, 1 hit
SUPFAMiSSF54368 SSF54368, 1 hit
SSF55931 SSF55931, 1 hit
TIGRFAMsiTIGR00653 GlnA, 1 hit
PROSITEiView protein in PROSITE
PS00180 GLNA_1, 1 hit
PS00181 GLNA_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UY99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVSEVKSGA TRSPKFVQLI FVDINGMPKG MEIPASRLQE AIEDGISFDG
60 70 80 90 100
SSVPGFQGIE DSDLIFKADP DTYVEVPWDN VARVYGYIYK DGKPYGADPR
110 120 130 140 150
GVLKRVIEKL AEMGIKAYIG PEPEFYLFKK NGSWELEIPD VGGYFDILTL
160 170 180 190 200
DKAKDIKREI AEYMPSFGLV PEVLHHEVGK AQHEIDFRYD EALKTADNII
210 220 230 240 250
SFKYIVKAVA EVHGLYATFM PKPIYGMPGN GMHLHISLWK EGENIFKGEE
260 270 280 290 300
GLSETALHFI GGLLKHAKAL TAITNPTVNS YKRLVPGYEA PVYISWGYKN
310 320 330 340 350
RSALIRVPAF WGNGARIEYR CPDPSANPYF AFAAILMAGL DGIKHKVEPF
360 370 380 390 400
AYVEENVYEM DEGKRKELGI DTLPGSLGEA LDELEKDKVV REALGEAYKN
410 420 430
FIEYKRKEWE SYLEYLEAKH LPKDTKRVTE WELERYFFI
Length:439
Mass (Da):49,743
Last modified:May 1, 2000 - v1
Checksum:i62CCFD3970A98AF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248288 Genomic DNA Translation: CAB50513.1
HE613800 Genomic DNA Translation: CCE71069.1
PIRiC75009
RefSeqiWP_010868727.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB50513; CAB50513; PAB1292
GeneIDi1495898
KEGGipab:PAB1292
PATRICifig|272844.11.peg.1718

Similar proteinsi

Entry informationi

Entry nameiGLN1A_PYRAB
AccessioniPrimary (citable) accession number: Q9UY99
Secondary accession number(s): G8ZJW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health