Q9UY68 (PURE_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutase
Short name=N5-CAIR mutase
EC=5.4.99.18

Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutase

Gene names

Name:	purE
Ordered Locus Names:	PYRAB16400
ORF Names:	PAB1077

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity.
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	N5-carboxyaminoimidazole ribonucleotide mutase		PRO_0000074988
Sites
	Binding site	15	1	Substrate By similarity
	Binding site	18	1	Substrate By similarity
	Binding site	45	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UY68 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5A37D37C0EC7FD01	FASTA	174	19,000
	10 20 30 40 50 60 MVKVGMPKVG IIMGSDSDLP VMKEAAKVLE DFEVDYEMKV ISAHRTPERL HEYARTAEER 70 80 90 100 110 120 GIEVIIAGAG GAAHLPGVLA ALTMIPVIGV PIKSKALNGL DSLLSIVQMP PGIPVATVGI 130 140 150 160 170 DGAKNAALLA LEILSIKYPE IKEKLKKYRE DMKRKVEEKS KKLEELGWRK YLEG

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248288 Genomic DNA. Translation: CAB50544.1.
PIR	B75013.
RefSeq	NP_127314.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9UY68.
SMR	Q9UY68. Positions 7-172.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003816; EBPYRP00000003747; EBPYRG00000003816.
GeneID	1495930.
GenomeReviews	Gene locus PYRAB16400 in contig AL096836_GR.
KEGG	pab:PAB1077.
NMPDR	fig|272844.1.peg.1740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023138.
HOGENOM	HBG301965.
OMA	LIMGSDS.
PhylomeDB	Q9UY68.
Enzyme and pathway databases
BioCyc	PABY272844:PAB1077-MONOMER.
Family and domain databases
InterPro	IPR024694. N5-CAIR_mutase_PurE. IPR000031. N5-CAIR_Mutase_PurE_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
KO	K01588.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
PIRSF	PIRSF001338. AIR_carboxylase. 1 hit.
SMART	SM01001. AIRC. 1 hit. [Graphical view]
SUPFAM	SSF52255. AIR_carboxyl. 1 hit.
TIGRFAMs	TIGR01162. PurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PURE_PYRAB

Accession

Primary (citable) accession number: Q9UY68

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program