Reviewed, UniProtKB/Swiss-Prot Q9UY68 (PUR6_PYRAB)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase catalytic subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	purE
Ordered Locus Names:	PYRAB16400
ORF Names:	PAB1077

Organism

Pyrococcus abyssi [Complete proteome] [HAMAP]

Taxonomic identifier

29292 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity.
Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Phosphoribosylaminoimidazole carboxylase catalytic subunit		PRO_0000074988
Sites
	Binding site	15	1	Substrate By similarity
	Binding site	18	1	Substrate By similarity
	Binding site	45	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UY68-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5A37D37C0EC7FD01	FASTA	174	19,000
	10 20 30 40 50 60 MVKVGMPKVG IIMGSDSDLP VMKEAAKVLE DFEVDYEMKV ISAHRTPERL HEYARTAEER 70 80 90 100 110 120 GIEVIIAGAG GAAHLPGVLA ALTMIPVIGV PIKSKALNGL DSLLSIVQMP PGIPVATVGI 130 140 150 160 170 DGAKNAALLA LEILSIKYPE IKEKLKKYRE DMKRKVEEKS KKLEELGWRK YLEG

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ248288 Genomic DNA. Translation: CAB50544.1.
PIR	B75013.
RefSeq	NP_127314.1.
3D structure databases
HSSP	HSSP built from PDB template 1O4V based on UniProtKB Q9WYS7.
ModBase	Search...
Genome annotation databases
GeneID	1495930.
GenomeReviews	Gene locus PYRAB16400 in contig AL096836_GR.
KEGG	pab:PAB1077.
NMPDR	fig|272844.1.peg.1740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9UY68.
OMA	GVVMGSS.
Enzyme and pathway databases
BioCyc	PABY272844:PAB1077-MON.
BRENDA	4.1.1.21. 262861.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR6_PYRAB

Accession

Primary (citable) accession number: Q9UY68

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)