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Q9UY53

- PCKG_PYRAB

UniProt

Q9UY53 - PCKG_PYRAB

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei83 – 831SubstrateUniRule annotation
    Binding sitei219 – 2191Substrate; via amide nitrogenUniRule annotation
    Metal bindingi226 – 2261ManganeseUniRule annotation
    Binding sitei226 – 2261SubstrateUniRule annotation
    Metal bindingi245 – 2451Manganese; via tele nitrogenUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Active sitei269 – 2691UniRule annotation
    Metal bindingi286 – 2861ManganeseUniRule annotation
    Binding sitei383 – 3831GTPUniRule annotation
    Binding sitei415 – 4151GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:PYRAB16550
    ORF Names:PAB1253
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 618618Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103617Add
    BLAST

    Proteomic databases

    PRIDEiQ9UY53.

    Interactioni

    Protein-protein interaction databases

    STRINGi272844.PAB1253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UY53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni381 – 3833Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiSEFLLYR.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UY53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLKRFLPE DQYEKLAAIN NPYLHEFLAE WIEWLKPSKV FVCTDSPEDE    50
    EYVRWKALYY GEEKMLEMPR HTVHYDNYYD QARDKANTKL LVPKGVTLPF 100
    LNTMDREEGL KEIREIMKGI MKGKELFICF FVLGPRNSIF TIPAVQLTDS 150
    AYVAHSEFLL YRKGYEEFKR LGPTKNFLKF VHSAGELDER KTSKNLDKRR 200
    IYIDLVDETV YSANTQYGGN TIGLKKLAFR LTIQRAVREG WLSEHMFLMR 250
    VNGPNGRKTY FTGAYPSMCG KTSTAMIPWE NIVGDDLVFI KNVDGTARAV 300
    NVEIGVFGII EGINEKDDPI IWQVLHSPVE IIFSNVLVKD GKPYWNGMGI 350
    EIPDEGENHS GKWWRGKRDK EGNEIPPSHK NARFTVRLEA FPNLDKEALE 400
    NPCGVEVGGM IFGGRDPDTW PPVREAFDWE HGVITMGASL ESETTAATLG 450
    KEGVRAFNPM SILDFLSVHL GDYIRNYLEF GRKLKKKPKI FAVNYFLREN 500
    GKWLNEKLDK AVWLKWMELR VHGDVEAIET PIGYIPKYED LRELFKQVLN 550
    KEYKKEDYEK QFKIRVPELL AKIDRIWNIY EPIGNIPEEL FKQLEEERER 600
    LLKAREKYGD YISPFSLL 618
    Length:618
    Mass (Da):71,880
    Last modified:May 1, 2000 - v1
    Checksum:i88E045DC671956E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50559.1.
    HE613800 Genomic DNA. Translation: CCE71123.1.
    PIRiA75015.
    RefSeqiNP_127329.1. NC_000868.1.
    WP_010868773.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB50559; CAB50559; PAB1253.
    GeneIDi1495952.
    KEGGipab:PAB1253.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50559.1 .
    HE613800 Genomic DNA. Translation: CCE71123.1 .
    PIRi A75015.
    RefSeqi NP_127329.1. NC_000868.1.
    WP_010868773.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9UY53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB1253.

    Proteomic databases

    PRIDEi Q9UY53.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50559 ; CAB50559 ; PAB1253 .
    GeneIDi 1495952.
    KEGGi pab:PAB1253.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi SEFLLYR.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiPCKG_PYRAB
    AccessioniPrimary (citable) accession number: Q9UY53
    Secondary accession number(s): G8ZK16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3