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Q9UY11

- SYW_PYRAB

UniProt

Q9UY11 - SYW_PYRAB

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:PYRAB16970
    ORF Names:PAB1111
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Tryptophan--tRNA ligasePRO_0000136727Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272844.PAB1111.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UY11.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi82 – 909"HIGH" region
    Motifi253 – 2575"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000224742.
    KOiK01867.
    OMAiKTFIFNN.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UY11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEDFKVTPW EVEGVVDYNK LIEHFGTSPL TEELLEKTAE LTKSELPLFF    50
    RRKFFFSHRD YDKVLQDYEE GRGFFLYTGR GPSGPMHIGH IIPFFATKWL 100
    QEKFGVNLYI QITDDEKFLF KENLTFEDTK HWAYENILDI IAVGFDPDKT 150
    FIFQNSEFTK IYEMAIPIAK KINFSMAKAV FGFTEQSKIG MIFFPAIQIA 200
    PTFFEKRRCL IPAAIDQDPY WRLQRDFAES LGYYKTAAIH SKFVPSLTSL 250
    SGKMSASKPE TAIYLTDSPE DVEKKVWKFA LTGGRPTLKE QREKGGEPEK 300
    CVVFKWLEIF FEEDDKKLKE RYYACKNGEL TCGECKRYLI SKIQEFLKEH 350
    QKRRKKAEKQ IEKFKYTGKL AQEMWDKAIP EPLKG 385
    Length:385
    Mass (Da):45,100
    Last modified:May 1, 2000 - v1
    Checksum:i4C29D01414976B12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50601.1.
    HE613800 Genomic DNA. Translation: CCE71167.1.
    PIRiC75020.
    RefSeqiNP_127372.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB50601; CAB50601; PAB1111.
    GeneIDi1495996.
    KEGGipab:PAB1111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50601.1 .
    HE613800 Genomic DNA. Translation: CCE71167.1 .
    PIRi C75020.
    RefSeqi NP_127372.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9UY11.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB1111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50601 ; CAB50601 ; PAB1111 .
    GeneIDi 1495996.
    KEGGi pab:PAB1111.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000224742.
    KOi K01867.
    OMAi KTFIFNN.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiSYW_PYRAB
    AccessioniPrimary (citable) accession number: Q9UY11
    Secondary accession number(s): G8ZK60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3