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Q9UXW3 (G6PI_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgiA
Ordered Locus Names:PYRAB17450
ORF Names:PAB1199
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_01410

Cofactor

Binds 1 iron ion per subunit By similarity. HAMAP-Rule MF_01410

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_01410

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01410

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01410.

Sequence similarities

Belongs to the archaeal-type GPI family.

Sequence caution

The sequence CCE71219.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Glucose-6-phosphate isomerase HAMAP-Rule MF_01410
PRO_0000185356

Sites

Metal binding881Iron By similarity
Metal binding901Iron By similarity
Metal binding971Iron By similarity
Metal binding1361Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UXW3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 904B3AA0FDDC64F9

FASTA18921,525
        10         20         30         40         50         60 
MYKEPLGVKV DFNTGVIPGA KKIVRRLSDM KGYFLDEKSW EELVKKEDPI VYEVYAIEQE 

        70         80         90        100        110        120 
EKEGDLNFAT TILYPGKVGK EFFFTKGHYH SKKDRAEVYV ALKGKGGMLL QTPEGEARWI 

       130        140        150        160        170        180 
PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA IYPADAGHDY GTIAERGFSK IVIEENGEVK 


VVDNPRWKS 

« Hide

References

« Hide 'large scale' references
[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.
[2]"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
Gao J., Wang J.
Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: GE5 / Orsay.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ248288 Genomic DNA. Translation: CAB50650.1.
HE613800 Genomic DNA. Translation: CCE71219.1. Different initiation.
PIRD75026.
RefSeqNP_127421.2. NC_000868.1.

3D structure databases

ProteinModelPortalQ9UXW3.
SMRQ9UXW3. Positions 1-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272844.PAB1199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB50650; CAB50650; PAB1199.
GeneID1496048.
KEGGpab:PAB1199.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2140.
HOGENOMHOG000243903.
KOK06859.
OMAYPADAGH.
ProtClustDBPRK04190.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_01410. G6P_isomerase_arch.
InterProIPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF06560. GPI. 1 hit.
[Graphical view]
PIRSFPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG6PI_PYRAB
AccessionPrimary (citable) accession number: Q9UXW3
Secondary accession number(s): G8ZKS8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways