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Q9UXW3

- G6PI_PYRAB

UniProt

Q9UXW3 - G6PI_PYRAB

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Protein
Glucose-6-phosphate isomerase
Gene
pgiA, PYRAB17450, PAB1199
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881Iron By similarity
Metal bindingi90 – 901Iron By similarity
Metal bindingi97 – 971Iron By similarity
Metal bindingi136 – 1361Iron By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgiA
Ordered Locus Names:PYRAB17450
ORF Names:PAB1199
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Glucose-6-phosphate isomeraseUniRule annotation
PRO_0000185356Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB1199.

Structurei

3D structure databases

ProteinModelPortaliQ9UXW3.
SMRiQ9UXW3. Positions 1-188.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal-type GPI family.

Phylogenomic databases

eggNOGiCOG2140.
HOGENOMiHOG000243903.
KOiK06859.
OMAiYPADAGH.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01410. G6P_isomerase_arch.
InterProiIPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06560. GPI. 1 hit.
[Graphical view]
PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UXW3-1 [UniParc]FASTAAdd to Basket

« Hide

MYKEPLGVKV DFNTGVIPGA KKIVRRLSDM KGYFLDEKSW EELVKKEDPI    50
VYEVYAIEQE EKEGDLNFAT TILYPGKVGK EFFFTKGHYH SKKDRAEVYV 100
ALKGKGGMLL QTPEGEARWI PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA 150
IYPADAGHDY GTIAERGFSK IVIEENGEVK VVDNPRWKS 189
Length:189
Mass (Da):21,525
Last modified:May 1, 2000 - v1
Checksum:i904B3AA0FDDC64F9
GO

Sequence cautioni

The sequence CCE71219.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248288 Genomic DNA. Translation: CAB50650.1.
HE613800 Genomic DNA. Translation: CCE71219.1. Different initiation.
PIRiD75026.
RefSeqiNP_127421.2. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50650; CAB50650; PAB1199.
GeneIDi1496048.
KEGGipab:PAB1199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248288 Genomic DNA. Translation: CAB50650.1 .
HE613800 Genomic DNA. Translation: CCE71219.1 . Different initiation.
PIRi D75026.
RefSeqi NP_127421.2. NC_000868.1.

3D structure databases

ProteinModelPortali Q9UXW3.
SMRi Q9UXW3. Positions 1-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB1199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB50650 ; CAB50650 ; PAB1199 .
GeneIDi 1496048.
KEGGi pab:PAB1199.

Phylogenomic databases

eggNOGi COG2140.
HOGENOMi HOG000243903.
KOi K06859.
OMAi YPADAGH.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_01410. G6P_isomerase_arch.
InterProi IPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF06560. GPI. 1 hit.
[Graphical view ]
PIRSFi PIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiG6PI_PYRAB
AccessioniPrimary (citable) accession number: Q9UXW3
Secondary accession number(s): G8ZKS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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