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Q9UXW3

- G6PI_PYRAB

UniProt

Q9UXW3 - G6PI_PYRAB

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Protein

Glucose-6-phosphate isomerase

Gene

pgiA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 iron ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881IronBy similarity
Metal bindingi90 – 901IronBy similarity
Metal bindingi97 – 971IronBy similarity
Metal bindingi136 – 1361IronBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgiA
Ordered Locus Names:PYRAB17450
ORF Names:PAB1199
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Glucose-6-phosphate isomerasePRO_0000185356Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272844.PAB1199.

Structurei

3D structure databases

ProteinModelPortaliQ9UXW3.
SMRiQ9UXW3. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal-type GPI family.Curated

Phylogenomic databases

eggNOGiCOG2140.
HOGENOMiHOG000243903.
KOiK06859.
OMAiYPADAGH.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01410. G6P_isomerase_arch.
InterProiIPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06560. GPI. 1 hit.
[Graphical view]
PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UXW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKEPLGVKV DFNTGVIPGA KKIVRRLSDM KGYFLDEKSW EELVKKEDPI
60 70 80 90 100
VYEVYAIEQE EKEGDLNFAT TILYPGKVGK EFFFTKGHYH SKKDRAEVYV
110 120 130 140 150
ALKGKGGMLL QTPEGEARWI PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA
160 170 180
IYPADAGHDY GTIAERGFSK IVIEENGEVK VVDNPRWKS
Length:189
Mass (Da):21,525
Last modified:May 1, 2000 - v1
Checksum:i904B3AA0FDDC64F9
GO

Sequence cautioni

The sequence CCE71219.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248288 Genomic DNA. Translation: CAB50650.1.
HE613800 Genomic DNA. Translation: CCE71219.1. Different initiation.
PIRiD75026.
RefSeqiNP_127421.2. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50650; CAB50650; PAB1199.
GeneIDi1496048.
KEGGipab:PAB1199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248288 Genomic DNA. Translation: CAB50650.1 .
HE613800 Genomic DNA. Translation: CCE71219.1 . Different initiation.
PIRi D75026.
RefSeqi NP_127421.2. NC_000868.1.

3D structure databases

ProteinModelPortali Q9UXW3.
SMRi Q9UXW3. Positions 1-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB1199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB50650 ; CAB50650 ; PAB1199 .
GeneIDi 1496048.
KEGGi pab:PAB1199.

Phylogenomic databases

eggNOGi COG2140.
HOGENOMi HOG000243903.
KOi K06859.
OMAi YPADAGH.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_01410. G6P_isomerase_arch.
InterProi IPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF06560. GPI. 1 hit.
[Graphical view ]
PIRSFi PIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiG6PI_PYRAB
AccessioniPrimary (citable) accession number: Q9UXW3
Secondary accession number(s): G8ZKS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3