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Q9UXU7 (VATA_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
V-type ATP synthase alpha chain
EC=3.6.3.14
Alternative name(s):
V-ATPase subunit A

Cleaved into the following chain:

  1. Pab AtpA intein
    Alternative name(s):
    Pab VMA intein
Gene names
Name:atpA
Ordered Locus Names:PYRAB17610
ORF Names:PAB2378
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length1017 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. HAMAP MF_00309

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_00309

Post-translational modification

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation Potential. HAMAP MF_00309

Miscellaneous

The intein interrupts the ATP-binding site. HAMAP MF_00309

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Contains 1 DOD-type homing endonuclease domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240V-type ATP synthase alpha chain, 1st part Potential
PRO_0000002461
Chain241 – 669429Pab AtpA intein Potential
PRO_0000002462
Chain670 – 1017348V-type ATP synthase alpha chain, 2nd part Potential
PRO_0000002463

Regions

Domain396 – 529134DOD-type homing endonuclease

Sequences

Sequence LengthMass (Da)Tools
Q9UXU7 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0F2008895F3E407A

FASTA1,017114,354
        10         20         30         40         50         60 
MVAKGRIIRV TGPLVVADGM KGAKMYEVVR VGELGLIGEI IRLEGDKAVI QVYEETAGVR 

        70         80         90        100        110        120 
PGEPVIGTGS SLSVELGPGL LTSIYDGIQR PLEVIREKTG DFIARGVTAP ALPRDKKWHF 

       130        140        150        160        170        180 
IPKVKVGDKV VGGDIIGEVP ETSIITHKIM VPPGIEGEIV EIAEEGEYTI EEVIAKVKTP 

       190        200        210        220        230        240 
SGEIKELKMY QRWPVRVKRP YKEKLPPEVP LITGQRVIDT FFPQAKGGTA AIPGPFGSGK 

       250        260        270        280        290        300 
CVDGDTLVLT KEFGLIKIKD LYKILDGKGK KTVNGNEEWT ELERPITLYG YKDGKIVEIK 

       310        320        330        340        350        360 
ATHVYKGFSA GMIEIRTRTG RKIKVTPIHK LFTGRVTKNG LEIREVMAKD LKKGDRIIVA 

       370        380        390        400        410        420 
KKIDGGERVK LNIRVEQKRG KKIRIPDVLD EKLAEFLGYL IADGTLKPRT VAIYNNDESL 

       430        440        450        460        470        480 
LRRANELANE LFNIEGKIVK GRTVKALLIH SKALVEFFSK LGVPRNKKAR TWKVPKELLI 

       490        500        510        520        530        540 
SEPEVVKAFI KAYIMCDGYY DENKGEIEIV TASEEAAYGF SYLLAKLGIY AIIREKIIGD 

       550        560        570        580        590        600 
KVYYRVVISG ESNLEKLGIE RVGRGYTSYD IVPVEVEELY NALGRPYAEL KRAGIEIHNY 

       610        620        630        640        650        660 
LSGENMSYEM FRKFAKFVGM EEIAENHLTH VLFDEIVEIR YISEGQEVYD VTTETHNFIG 

       670        680        690        700        710        720 
GNMPTLLHNT VTQHQLAKWS DAQVVIYIGC GERGNEMTDV LEEFPKLKDP KTGKPLMERT 

       730        740        750        760        770        780 
VLIANTSNMP VAAREASIYT GITIAEYFRD MGYDVALMAD STSRWAEALR EISGRLEEMP 

       790        800        810        820        830        840 
GEEGYPAYLA SKLAEFYERA GRVVTLGSDY RVGSVSVIGA VSPPGGDFSE PVVQNTLRVV 

       850        860        870        880        890        900 
KVFWALDADL ARRRHFPAIN WLTSYSLYVD AVKDWWHKNV DPEWKAMRDK AMELLQKESE 

       910        920        930        940        950        960 
LQEIVRIVGP DALPERERAI LLVARMLRED YLQQDAFDEV DTYCPPEKQV TMMRVLLNFY 

       970        980        990       1000       1010 
DKTMEAISRG VPLEEIAKLP VREEIGRMKF EPDVGKIKAL IDKTNEQFEE LFKKYGA

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References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ248288 Genomic DNA. Translation: CAB50666.1.
PIRD75028.
RefSeqNP_127437.1. NC_000868.1.

3D structure databases

ProteinModelPortalQ9UXU7.
SMRQ9UXU7. Positions 60-287, 670-1017.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000002595; EBPYRP00000002526; EBPYRG00000002595.
GeneID1496064.
GenomeReviewsGene locus PYRAB17610 in contig AL096836_GR.
KEGGpab:PAB2378.
NMPDRfig|272844.1.peg.1874.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022151.
HOGENOMHBG288114.
OMAHNCGERG.
PhylomeDBQ9UXU7.
ProtClustDBPRK14698.

Enzyme and pathway databases

BioCycPABY272844:PAB2378-MONOMER.

Family and domain databases

HAMAPMF_00309. ATP_synth_A_arch. Divergent sequence.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1_bsu/V1_C.
IPR003586. Hedgehog_hint_C.
IPR003587. Hedgehog_hint_N.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR022878. V-ATPase_su_A/alpha.
[Graphical view]
Gene3DG3DSA:1.10.1140.10. G3DSA:1.10.1140.10. 1 hit.
KOK02117.
PfamPF00006. ATP-synt_ab. 2 hits.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PRINTSPR00379. INTEIN.
SMARTSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR01443. Intein_Cterm. 1 hit.
TIGR01445. Intein_Nterm. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVATA_PYRAB
AccessionPrimary (citable) accession number: Q9UXU7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Intein-containing proteins

List of intein-containing protein entries

SIMILARITY comments

Index of protein domains and families

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