Reviewed,
UniProtKB/Swiss-Prot Q9UXU7 (VATA_PYRAB)
Last modified
November 24, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: V-type ATP synthase alpha chain EC=3.6.3.14 Alternative name(s): V-ATPase subunit A Cleaved into the following chain: 1- Recommended name: Pab atpA intein Alternative name(s): Pab VMA intein | ||||||
| Gene names |
| ||||||
| Organism | Pyrococcus abyssi [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 29292 [NCBI] | ||||||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
Protein attributes
| Sequence length | 1017 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. HAMAP MF_00309 |
| Catalytic activity | ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_00309 |
| Post-translational modification | This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation Potential. |
| Miscellaneous | The intein interrupts the ATP-binding site. HAMAP MF_00309 |
| Sequence similarities | Belongs to the ATPase alpha/beta chains family. Contains 1 DOD-type homing endonuclease domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | ATP synthesis Hydrogen ion transport Ion transport Transport |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| PTM | Autocatalytic cleavage Protein splicing |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | intein-mediated protein splicing Inferred from electronic annotation. Source: InterPro plasma membrane ATP synthesis coupled proton transportInferred from electronic annotation. Source: HAMAP |
| Cellular component | proton-transporting two-sector ATPase complex, catalytic domain Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP endonuclease activityInferred from electronic annotation. Source: InterPro hydrogen ion transporting ATP synthase activity, rotational mechanismInferred from electronic annotation. Source: HAMAP proton-transporting ATPase activity, rotational mechanismInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 240 | 240 | V-type ATP synthase alpha chain, 1st part Potential | PRO_0000002461 | |||||
| Chain | 241 – 669 | 429 | Pab atpA intein Potential | PRO_0000002462 | |||||
| Chain | 670 – 1017 | 348 | V-type ATP synthase alpha chain, 2nd part Potential | PRO_0000002463 | |||||
Regions | |||||||||
| Domain | 396 – 529 | 134 | DOD-type homing endonuclease | ||||||
Sequences
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References
| [1] | "An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay. |
Cross-references
Sequence databases | |
|---|---|
| AJ248288 Genomic DNA. Translation: CAB50666.1. | |
| PIR | D75028. |
| RefSeq | NP_127437.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1496064. |
| GenomeReviews | Gene locus PYRAB17610 in contig AL096836_GR. |
| KEGG | pab:PAB2378. |
| NMPDR | fig|272844.1.peg.1874. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q9UXU7. |
| OMA | HNCGERG |
Enzyme and pathway databases | |
| BioCyc | PABY272844:PAB2378-MON. |
| BRENDA | 3.6.3.14. 262861. |
Family and domain databases | |
| HAMAP | MF_00309. Divergent sequence. [Tree] |
| InterPro | IPR018118. ATPase_F1/A1-cplx_a/bsu_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR020003. ATPase_F1/V1/A1_a/bsu_AS. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splicing_site. [Graphical view] |
| Pfam | PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view] |
| PRINTS | PR00379. INTEIN. |
| SMART | SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01443. intein_Cterm. 1 hit. TIGR01445. intein_Nterm. 1 hit. |
| PROSITE | PS00152. ATPASE_ALPHA_BETA. 1 hit. PS50818. INTEIN_C_TER. 1 hit. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | VATA_PYRAB | ||||||||
| Accession | Primary (citable) accession number: Q9UXU7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Intein-containing proteins List of intein-containing protein entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


