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Q9UXU7

- VATA_PYRAB

UniProt

Q9UXU7 - VATA_PYRAB

Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. endonuclease activity Source: InterPro
    3. hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Source: InterPro

    GO - Biological processi

    1. ATP biosynthetic process Source: UniProtKB-KW
    2. ATP hydrolysis coupled proton transport Source: InterPro
    3. intein-mediated protein splicing Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type ATP synthase alpha chain (EC:3.6.3.14)
    Alternative name(s):
    V-ATPase subunit A
    Cleaved into the following chain:
    Alternative name(s):
    Pab VMA intein
    Gene namesi
    Name:atpA
    Ordered Locus Names:PYRAB17610
    ORF Names:PAB2378
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240V-type ATP synthase alpha chain, 1st partSequence AnalysisPRO_0000002461Add
    BLAST
    Chaini241 – 669429Pab AtpA inteinSequence AnalysisPRO_0000002462Add
    BLAST
    Chaini670 – 1017348V-type ATP synthase alpha chain, 2nd partSequence AnalysisPRO_0000002463Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Interactioni

    Protein-protein interaction databases

    STRINGi272844.PAB2378.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UXU7.
    SMRiQ9UXU7. Positions 60-287, 670-1017.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini396 – 529134DOD-type homing endonucleaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.Curated

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000161057.
    KOiK02117.
    OMAiVHNCGER.

    Family and domain databases

    Gene3Di1.10.1140.10. 1 hit.
    2.170.16.10. 3 hits.
    3.10.28.10. 2 hits.
    3.40.50.300. 3 hits.
    HAMAPiMF_00309. ATP_synth_A_arch.
    InterProiIPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR006142. INTEIN.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 2 hits.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    PF14528. LAGLIDADG_3. 1 hit.
    [Graphical view]
    PRINTSiPR00379. INTEIN.
    SMARTiSM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    SSF55608. SSF55608. 1 hit.
    TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50819. INTEIN_ENDONUCLEASE. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UXU7-1 [UniParc]FASTAAdd to Basket

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    MVAKGRIIRV TGPLVVADGM KGAKMYEVVR VGELGLIGEI IRLEGDKAVI     50
    QVYEETAGVR PGEPVIGTGS SLSVELGPGL LTSIYDGIQR PLEVIREKTG 100
    DFIARGVTAP ALPRDKKWHF IPKVKVGDKV VGGDIIGEVP ETSIITHKIM 150
    VPPGIEGEIV EIAEEGEYTI EEVIAKVKTP SGEIKELKMY QRWPVRVKRP 200
    YKEKLPPEVP LITGQRVIDT FFPQAKGGTA AIPGPFGSGK CVDGDTLVLT 250
    KEFGLIKIKD LYKILDGKGK KTVNGNEEWT ELERPITLYG YKDGKIVEIK 300
    ATHVYKGFSA GMIEIRTRTG RKIKVTPIHK LFTGRVTKNG LEIREVMAKD 350
    LKKGDRIIVA KKIDGGERVK LNIRVEQKRG KKIRIPDVLD EKLAEFLGYL 400
    IADGTLKPRT VAIYNNDESL LRRANELANE LFNIEGKIVK GRTVKALLIH 450
    SKALVEFFSK LGVPRNKKAR TWKVPKELLI SEPEVVKAFI KAYIMCDGYY 500
    DENKGEIEIV TASEEAAYGF SYLLAKLGIY AIIREKIIGD KVYYRVVISG 550
    ESNLEKLGIE RVGRGYTSYD IVPVEVEELY NALGRPYAEL KRAGIEIHNY 600
    LSGENMSYEM FRKFAKFVGM EEIAENHLTH VLFDEIVEIR YISEGQEVYD 650
    VTTETHNFIG GNMPTLLHNT VTQHQLAKWS DAQVVIYIGC GERGNEMTDV 700
    LEEFPKLKDP KTGKPLMERT VLIANTSNMP VAAREASIYT GITIAEYFRD 750
    MGYDVALMAD STSRWAEALR EISGRLEEMP GEEGYPAYLA SKLAEFYERA 800
    GRVVTLGSDY RVGSVSVIGA VSPPGGDFSE PVVQNTLRVV KVFWALDADL 850
    ARRRHFPAIN WLTSYSLYVD AVKDWWHKNV DPEWKAMRDK AMELLQKESE 900
    LQEIVRIVGP DALPERERAI LLVARMLRED YLQQDAFDEV DTYCPPEKQV 950
    TMMRVLLNFY DKTMEAISRG VPLEEIAKLP VREEIGRMKF EPDVGKIKAL 1000
    IDKTNEQFEE LFKKYGA 1017
    Length:1,017
    Mass (Da):114,354
    Last modified:May 1, 2000 - v1
    Checksum:i0F2008895F3E407A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50666.1.
    HE613800 Genomic DNA. Translation: CCE71235.1.
    PIRiD75028.
    RefSeqiNP_127437.1. NC_000868.1.
    WP_010868880.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB50666; CAB50666; PAB2378.
    GeneIDi1496064.
    KEGGipab:PAB2378.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50666.1 .
    HE613800 Genomic DNA. Translation: CCE71235.1 .
    PIRi D75028.
    RefSeqi NP_127437.1. NC_000868.1.
    WP_010868880.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9UXU7.
    SMRi Q9UXU7. Positions 60-287, 670-1017.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB2378.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50666 ; CAB50666 ; PAB2378 .
    GeneIDi 1496064.
    KEGGi pab:PAB2378.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000161057.
    KOi K02117.
    OMAi VHNCGER.

    Family and domain databases

    Gene3Di 1.10.1140.10. 1 hit.
    2.170.16.10. 3 hits.
    3.10.28.10. 2 hits.
    3.40.50.300. 3 hits.
    HAMAPi MF_00309. ATP_synth_A_arch.
    InterProi IPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR006142. INTEIN.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 2 hits.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    PF14528. LAGLIDADG_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00379. INTEIN.
    SMARTi SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    SSF55608. SSF55608. 1 hit.
    TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50819. INTEIN_ENDONUCLEASE. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiVATA_PYRAB
    AccessioniPrimary (citable) accession number: Q9UXU7
    Secondary accession number(s): G8ZKU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The intein interrupts the ATP-binding site.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3