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Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

Miscellaneous

The intein interrupts the ATP-binding site.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Cleaved into the following chain:
Alternative name(s):
Pab VMA intein
Gene namesi
Name:atpA
Ordered Locus Names:PYRAB17610
ORF Names:PAB2378
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000024611 – 240V-type ATP synthase alpha chain, 1st partSequence analysisAdd BLAST240
ChainiPRO_0000002462241 – 669Pab AtpA inteinSequence analysisAdd BLAST429
ChainiPRO_0000002463670 – 1017V-type ATP synthase alpha chain, 2nd partSequence analysisAdd BLAST348

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB2378.

Structurei

3D structure databases

ProteinModelPortaliQ9UXU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini396 – 529DOD-type homing endonucleaseAdd BLAST134

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiarCOG00868. Archaea.
arCOG03154. Archaea.
COG1155. LUCA.
HOGENOMiHOG000161057.
KOiK02117.
OMAiHNTVTQH.
OrthoDBiPOG093Z00V1.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.10.28.10. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiView protein in InterPro
IPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_b/a_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR030934. Intein_C.
IPR004042. Intein_endonuc.
IPR006141. Intein_N.
IPR004860. LAGLIDADG_2.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
PANTHERiPTHR43607. PTHR43607. 1 hit.
PfamiView protein in Pfam
PF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
PRINTSiPR00379. INTEIN.
SMARTiView protein in SMART
SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF52540. SSF52540. 2 hits.
SSF55608. SSF55608. 1 hit.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiView protein in PROSITE
PS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UXU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKGRIIRV TGPLVVADGM KGAKMYEVVR VGELGLIGEI IRLEGDKAVI
60 70 80 90 100
QVYEETAGVR PGEPVIGTGS SLSVELGPGL LTSIYDGIQR PLEVIREKTG
110 120 130 140 150
DFIARGVTAP ALPRDKKWHF IPKVKVGDKV VGGDIIGEVP ETSIITHKIM
160 170 180 190 200
VPPGIEGEIV EIAEEGEYTI EEVIAKVKTP SGEIKELKMY QRWPVRVKRP
210 220 230 240 250
YKEKLPPEVP LITGQRVIDT FFPQAKGGTA AIPGPFGSGK CVDGDTLVLT
260 270 280 290 300
KEFGLIKIKD LYKILDGKGK KTVNGNEEWT ELERPITLYG YKDGKIVEIK
310 320 330 340 350
ATHVYKGFSA GMIEIRTRTG RKIKVTPIHK LFTGRVTKNG LEIREVMAKD
360 370 380 390 400
LKKGDRIIVA KKIDGGERVK LNIRVEQKRG KKIRIPDVLD EKLAEFLGYL
410 420 430 440 450
IADGTLKPRT VAIYNNDESL LRRANELANE LFNIEGKIVK GRTVKALLIH
460 470 480 490 500
SKALVEFFSK LGVPRNKKAR TWKVPKELLI SEPEVVKAFI KAYIMCDGYY
510 520 530 540 550
DENKGEIEIV TASEEAAYGF SYLLAKLGIY AIIREKIIGD KVYYRVVISG
560 570 580 590 600
ESNLEKLGIE RVGRGYTSYD IVPVEVEELY NALGRPYAEL KRAGIEIHNY
610 620 630 640 650
LSGENMSYEM FRKFAKFVGM EEIAENHLTH VLFDEIVEIR YISEGQEVYD
660 670 680 690 700
VTTETHNFIG GNMPTLLHNT VTQHQLAKWS DAQVVIYIGC GERGNEMTDV
710 720 730 740 750
LEEFPKLKDP KTGKPLMERT VLIANTSNMP VAAREASIYT GITIAEYFRD
760 770 780 790 800
MGYDVALMAD STSRWAEALR EISGRLEEMP GEEGYPAYLA SKLAEFYERA
810 820 830 840 850
GRVVTLGSDY RVGSVSVIGA VSPPGGDFSE PVVQNTLRVV KVFWALDADL
860 870 880 890 900
ARRRHFPAIN WLTSYSLYVD AVKDWWHKNV DPEWKAMRDK AMELLQKESE
910 920 930 940 950
LQEIVRIVGP DALPERERAI LLVARMLRED YLQQDAFDEV DTYCPPEKQV
960 970 980 990 1000
TMMRVLLNFY DKTMEAISRG VPLEEIAKLP VREEIGRMKF EPDVGKIKAL
1010
IDKTNEQFEE LFKKYGA
Length:1,017
Mass (Da):114,354
Last modified:May 1, 2000 - v1
Checksum:i0F2008895F3E407A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248288 Genomic DNA. Translation: CAB50666.1.
HE613800 Genomic DNA. Translation: CCE71235.1.
PIRiD75028.
RefSeqiWP_010868880.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50666; CAB50666; PAB2378.
GeneIDi1496064.
KEGGipab:PAB2378.
PATRICifig|272844.11.peg.1880.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVATA_PYRAB
AccessioniPrimary (citable) accession number: Q9UXU7
Secondary accession number(s): G8ZKU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families