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Q9UXT1

- GCSPB_PYRAB

UniProt

Q9UXT1 - GCSPB_PYRAB

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, PYRAB17770, PAB1172
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:PYRAB17770
ORF Names:PAB1172
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi272844.PAB1172.

Structurei

3D structure databases

ProteinModelPortaliQ9UXT1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UXT1-1 [UniParc]FASTAAdd to Basket

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MYRQAKWDEP LIFELSRPGR VGYTLPKPIE DVDVEIPEKL KRKSPLNLPE    50
VSEPEVVKHY TRLSEMNYGV DSGIYPLGSC TMKYNPKINE ELAGHPKVAY 100
IHPYQDERTV QGALRIMWEL EQWLKEITGM DRFTLQPAAG ANGEFTGVMI 150
IKAYHLDRGE TQRNEMLVPD SAHGTNPASA AMAGFKVIEI PSNENGTVDL 200
EALENAVSER TAGLMLTNPN TLGIFEDEIE EIAKIVHKAG GLLYYDGANL 250
NGILGKVRPG DMGFDIVHLN LHKTFSTPHG GGGPGAGPVG VKEFLKDYLP 300
VPLVSYDEEN DRYYLDYDVP KSIGKVKELF GNFAVLVRAL TYLKVMGKDG 350
LREVSEVAVL NANYLARKLK GTRGYELPHK ELRKHEVVFS AEPMKRETGV 400
RTLDVAKRLL DFGMHAPTIY FPLIVHEALM IEPTETVSKE ELDAYVEAMK 450
KISEEAYTNP EVVKSAPHNT AVRRVDDVLA SKKPIITWKM YKELKEKGEV 500
DY 502
Length:502
Mass (Da):56,288
Last modified:May 1, 2000 - v1
Checksum:iF8E8C9CFA27EBD3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248288 Genomic DNA. Translation: CAB50682.1.
HE613800 Genomic DNA. Translation: CCE71251.1.
PIRiD75030.
RefSeqiNP_127453.1. NC_000868.1.
WP_010868896.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50682; CAB50682; PAB1172.
GeneIDi1496080.
KEGGipab:PAB1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248288 Genomic DNA. Translation: CAB50682.1 .
HE613800 Genomic DNA. Translation: CCE71251.1 .
PIRi D75030.
RefSeqi NP_127453.1. NC_000868.1.
WP_010868896.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9UXT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB1172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB50682 ; CAB50682 ; PAB1172 .
GeneIDi 1496080.
KEGGi pab:PAB1172.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiGCSPB_PYRAB
AccessioniPrimary (citable) accession number: Q9UXT1
Secondary accession number(s): G8ZKW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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