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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1963-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:PYRAB17780
ORF Names:PAB1171
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669841 – 449Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST449

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB1171

Structurei

3D structure databases

ProteinModelPortaliQ9UXT0
SMRiQ9UXT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UXT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHYIPNSA HKEEMLKEIG LSSIDELFAD IPGKFIRDEL NLPEGKSEYE
60 70 80 90 100
VFLEMNEILG KNKTVLEMPT FLGAGTYFHY IPAHVKYLIE RSEFLTAYTP
110 120 130 140 150
YQPEISQGML QALFEYQSLI AELVGLPVVN ASMYDWGTAM AEAALMTVRL
160 170 180 190 200
HRGKRKKFIV PRHTHPERLQ VLETYAKGPG VEIETVKWNE RGQVDIEDLK
210 220 230 240 250
EKVKDAAGVY VEIPNFFGLL EEEVREIGEI AHEAGAYFVV GVDPTILGIV
260 270 280 290 300
EAPGELGADI VVGEASYFGN PMNFGGPRAG IFAVRNDMKL IRQMPGRLIG
310 320 330 340 350
MTKDAEGKRA FVMTLQTREQ HIRRAKATSN ICSNEALVAV AAAIHIASLG
360 370 380 390 400
PRGIRELGEV ILKNTAYLKK RLSEVAEIPF DGVNFKDVLV RFEKPYKEIH
410 420 430 440
EELLKRNIHG GYYVGKHFPE LGESALFAAT ETTRKEWVDA LISALREVI
Length:449
Mass (Da):50,319
Last modified:May 1, 2000 - v1
Checksum:i198007620423E937
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248288 Genomic DNA Translation: CAB50683.1
HE613800 Genomic DNA Translation: CCE71252.1
PIRiE75030
RefSeqiWP_010868897.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB50683; CAB50683; PAB1171
GeneIDi1496081
KEGGipab:PAB1171
PATRICifig|272844.11.peg.1897

Similar proteinsi

Entry informationi

Entry nameiGCSPA_PYRAB
AccessioniPrimary (citable) accession number: Q9UXT0
Secondary accession number(s): G8ZKW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health