Glycerol-1-phosphate dehydrogenase [NAD(P)+]

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Reviewed, UniProtKB/Swiss-Prot Q9UXE7 (G1PDH_SULSO)

Last modified November 3, 2009. Version 52. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Glycerol-1-phosphate dehydrogenase [NAD(P)+]
      Short name=G1P dehydrogenase
      Short name=G1PDH
    EC=1.1.1.261
Alternative name(s):
    sn-glycerol-1-phosphate dehydrogenase
    Enantiomeric glycerophosphate synthase

Gene names

Name:	egsA
Synonyms:	gldA
Ordered Locus Names:	SSO0760

Organism

Sulfolobus solfataricus [Complete proteome] [HAMAP]

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

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Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol-1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea By similarity.
Catalytic activity	sn-glycerol-1-phosphate + NAD(P)⁺ = glycerone phosphate + NAD(P)H. HAMAP MF_00497
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP MF_00497
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the glycerol-1-phosphate dehydrogenase family.

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Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cytoplasm
Ligand	Metal-binding NAD NADP Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: InterPro glycerol-1-phosphate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 351

351

Glycerol-1-phosphate dehydrogenase [NAD(P)+] HAMAP MF_00497

PRO_0000157353

Regions

Nucleotide binding

97 – 101

NAD By similarity

Nucleotide binding

119 – 122

NAD By similarity

Sites

Metal binding

171

Zinc; catalytic By similarity

Metal binding

251

Zinc; catalytic By similarity

Metal binding

267

Zinc; catalytic By similarity

Binding site

124

Substrate By similarity

Binding site

128

NAD By similarity

Binding site

171

Substrate By similarity

Binding site

255

Substrate By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9UXE7-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C930E3DC1CA636EF
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FASTA

351

38,484

        10         20         30         40         50         60 
MNVKEHVISL PRRVFVGHDI VYDISIYFSQ LGVTPPFLIV TGTKYTKKIA DKVIENLPKD 

        70         80         90        100        110        120 
AKYEVVEIDS ATLDDVYMVE EVIKRISPSL LLGIGGGKVI DVTKYAAFRN SLEFVSIPTS 

       130        140        150        160        170        180 
PSHDGITSPF ASIKGLQKPV SVKAKEPLAI IADIEILSLS PRRLINAGIG DTIGKIIAVR 

       190        200        210        220        230        240 
DWKLAAKLRG EYYGDYTASL ALMSAKHAFQ CTKIINKDIK YGVRMLMEAL ISSGVAMGMA 

       250        260        270        280        290        300 
GSTRPASGSE HLFAHAVELI HPEGILHGEL VGLGTIIMAY LHGINWKIIR NRLKKIGFPV 

       310        320        330        340        350 
KAKDLGLSDE EVIKALTIAH TIRPERYTIL GDRGLTWSSA EKIARVTKII D

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References

[1]

"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2."
Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N.

Sensen C.W.
Genome 43:116-136(2000) [PubMed: 10701121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

[2]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.

Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

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Cross-references

Sequence databases
	Y18930 Genomic DNA. Translation: CAB57543.1. AE006641 Genomic DNA. Translation: AAK41055.1.
PIR	H90224.
RefSeq	NP_342265.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1455022.
GenomeReviews	Gene locus SSO0760 in contig AE006641_GR.
KEGG	sso:SSO0760.
NMPDR	fig\|273057.1.peg.688.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9UXE7.
OMA	ADWELAH.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0760-MON.
BRENDA	1.1.1.261. 2070.
Family and domain databases
HAMAP	MF_00497. [Tree]
InterPro	IPR002658. DHQ_synth_AroB. IPR016205. Glycerol_DH. [Graphical view]
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000112. Glycerol_dehydrogenase. 1 hit.
ProtoNet	Search...

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Entry information

Entry name

G1PDH_SULSO

Accession

Primary (citable) accession number: Q9UXE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents