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Protein

Exosome complex component Rrp41

Gene

rrp41

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. Binds RNA.UniRule annotation3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component Rrp41UniRule annotation (EC:3.1.13.-UniRule annotation)
Gene namesi
Name:rrp41UniRule annotation
Ordered Locus Names:SSO0735
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98R → E: Abolishes exoribonuclease activity; when associated with E-99. 1 Publication1
Mutagenesisi99R → E: Abolishes exoribonuclease activity; when associated with E-98. 1 Publication1
Mutagenesisi182D → A: Abolishes both exoribonuclease and polyadenylation activities. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001399911 – 248Exosome complex component Rrp41Add BLAST248

Interactioni

Subunit structurei

Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.UniRule annotation6 Publications

Protein-protein interaction databases

DIPiDIP-58154N.
IntActiQ9UXC2. 1 interactor.
MINTiMINT-7891191.
STRINGi273057.SSO0735.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi15 – 17Combined sources3
Beta strandi31 – 36Combined sources6
Beta strandi39 – 49Combined sources11
Beta strandi52 – 63Combined sources12
Helixi67 – 69Combined sources3
Beta strandi72 – 74Combined sources3
Beta strandi76 – 83Combined sources8
Beta strandi87 – 90Combined sources4
Helixi98 – 112Combined sources15
Helixi117 – 119Combined sources3
Beta strandi123 – 133Combined sources11
Helixi138 – 152Combined sources15
Beta strandi157 – 159Combined sources3
Beta strandi162 – 169Combined sources8
Beta strandi172 – 176Combined sources5
Helixi179 – 184Combined sources6
Beta strandi185 – 194Combined sources10
Helixi195 – 197Combined sources3
Beta strandi199 – 207Combined sources9
Helixi211 – 237Combined sources27
Helixi238 – 240Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BR2X-ray2.80B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C37X-ray2.80B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C38X-ray3.10B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C39X-ray3.30B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2JE6X-ray1.60B1-248[»]
2JEAX-ray2.33B1-248[»]
2JEBX-ray2.40B1-248[»]
3L7ZX-ray2.41B/E/H4-248[»]
4BA1X-ray1.80B1-248[»]
4BA2X-ray2.50B1-248[»]
ProteinModelPortaliQ9UXC2.
SMRiQ9UXC2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UXC2.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family. Rrp41 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01575. Archaea.
COG0689. LUCA.
HOGENOMiHOG000229515.
InParanoidiQ9UXC2.
KOiK11600.
OMAiDITLLQM.

Family and domain databases

CDDicd11366. RNase_PH_archRRP41. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00591. Exosome_Rrp41. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR011807. Rrp41.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR02065. ECX1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UXC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREMLQVERP KLILDDGKRT DGRKPDELRS IKIELGVLKN ADGSAIFEMG
60 70 80 90 100
NTKAIAAVYG PKEMHPRHLS LPDRAVLRVR YHMTPFSTDE RKNPAPSRRE
110 120 130 140 150
IELSKVIREA LESAVLVELF PRTAIDVFTE ILQADAGSRL VSLMAASLAL
160 170 180 190 200
ADAGIPMRDL IAGVAVGKAD GVIILDLNET EDMWGEADMP IAMMPSLNQV
210 220 230 240
TLFQLNGSMT PDEFRQAFDL AVKGINIIYN LEREALKSKY VEFKEEGV
Length:248
Mass (Da):27,578
Last modified:May 1, 2000 - v1
Checksum:iEAB2C2C89DD5854C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57569.1.
AE006641 Genomic DNA. Translation: AAK41031.1.
PIRiH90221.

Genome annotation databases

EnsemblBacteriaiAAK41031; AAK41031; SSO0735.
KEGGisso:SSO0735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57569.1.
AE006641 Genomic DNA. Translation: AAK41031.1.
PIRiH90221.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BR2X-ray2.80B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C37X-ray2.80B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C38X-ray3.10B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C39X-ray3.30B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2JE6X-ray1.60B1-248[»]
2JEAX-ray2.33B1-248[»]
2JEBX-ray2.40B1-248[»]
3L7ZX-ray2.41B/E/H4-248[»]
4BA1X-ray1.80B1-248[»]
4BA2X-ray2.50B1-248[»]
ProteinModelPortaliQ9UXC2.
SMRiQ9UXC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58154N.
IntActiQ9UXC2. 1 interactor.
MINTiMINT-7891191.
STRINGi273057.SSO0735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41031; AAK41031; SSO0735.
KEGGisso:SSO0735.

Phylogenomic databases

eggNOGiarCOG01575. Archaea.
COG0689. LUCA.
HOGENOMiHOG000229515.
InParanoidiQ9UXC2.
KOiK11600.
OMAiDITLLQM.

Miscellaneous databases

EvolutionaryTraceiQ9UXC2.

Family and domain databases

CDDicd11366. RNase_PH_archRRP41. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00591. Exosome_Rrp41. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR011807. Rrp41.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR02065. ECX1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRRP41_SULSO
AccessioniPrimary (citable) accession number: Q9UXC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.