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Q9UXC0 (ECX2_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable exosome complex exonuclease 2
EC=3.1.13.-
Gene names
Ordered Locus Names:SSO0732
ORF Names:C20_023
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in the 3'->5' degradation of a variety of RNA species Potential. HAMAP MF_00622

Subunit structure

Component of the archaeal exosome multienzyme ribonuclease complex Potential.

Subcellular location

Cytoplasm Potential HAMAP MF_00622.

Sequence similarities

Belongs to the RNase PH family.

Ontologies

Keywords
   Cellular componentCytoplasm
Exosome
   Molecular functionExonuclease
Hydrolase
Nuclease
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processRNA catabolic process

Inferred from electronic annotation. Source: InterPro

RNA processing

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

exosome (RNase complex)

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3'-5' exonuclease activity

Inferred from electronic annotation. Source: InterPro

RNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Probable exosome complex exonuclease 2 HAMAP MF_00622
PRO_0000140006

Secondary structure

1 ...................................... 275
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9UXC0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4188C9D6928A144C

FASTA27530,194
        10         20         30         40         50         60 
MSSTPSNQNI IPIIKKESIV SLFEKGIRQD GRKLTDYRPL SITLDYAKKA DGSALVKLGT 

        70         80         90        100        110        120 
TMVLAGTKLE IDKPYEDTPN QGNLIVNVEL LPLAYETFEP GPPDENAIEL ARVVDRSLRD 

       130        140        150        160        170        180 
SKALDLTKLV IEPGKSVWTV WLDVYVLDYG GNVLDACTLA SVAALYNTKV YKVEQHSNGI 

       190        200        210        220        230        240 
SVNKNEVVGK LPLNYPVVTI SVAKVDKYLV VDPDLDEESI MDAKISFSYT PDLKIVGIQK 

       250        260        270 
SGKGSMSLQD IDQAENTARS TAVKLLEELK KHLGI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y18930 Genomic DNA. Translation: CAB57571.1.
AE006641 Genomic DNA. Translation: AAK41030.1.
PIRG90221.
RefSeqNP_342240.1. NC_002754.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BR2X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C37X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C38X-ray3.10A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C39X-ray3.30A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2JE6X-ray1.60A1-275[»]
2JEAX-ray2.33A1-275[»]
2JEBX-ray2.40A1-275[»]
3L7ZX-ray2.41A/D/G1-275[»]
ProteinModelPortalQ9UXC0.
SMRQ9UXC0. Positions 1-275.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1454997.
GenomeReviewsGene locus SSO0732 in contig AE006641_GR.
KEGGsso:SSO0732.
NMPDRfig|273057.1.peg.663.

Phylogenomic databases

HOGENOMHBG737187.
OMAFIDVHVL.
ProtClustDBPRK04282.

Enzyme and pathway databases

BioCycSSOL273057:SSO0732-MONOMER.

Family and domain databases

HAMAPMF_00622. Exosome_Exonucl_2.
[Tree]
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR020869. Exosome_complex_exonuc_2_prob.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
KOK12589.
PfamPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMSSF55666. 3_ExoRNase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
ProtoNetSearch...

Entry information

Entry nameECX2_SULSO
AccessionPrimary (citable) accession number: Q9UXC0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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