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Protein

Exosome complex component Rrp42

Gene

rrp42

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.UniRule annotation2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component Rrp42UniRule annotation
Gene namesi
Name:rrp42UniRule annotation
Ordered Locus Names:SSO0732
ORF Names:C20_023
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi112R → E: Abolishes exoribonuclease activity of the complex; when associated with E-116. 1 Publication1
Mutagenesisi116R → E: Abolishes exoribonuclease activity of the complex; when associated with E-112. 1 Publication1
Mutagenesisi218E → A: Does not change activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001400061 – 275Exosome complex component Rrp42Add BLAST275

Interactioni

Subunit structurei

Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.UniRule annotation6 Publications

Protein-protein interaction databases

DIPiDIP-60492N.
STRINGi273057.SSO0732.

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 19Combined sources7
Turni20 – 22Combined sources3
Helixi23 – 25Combined sources3
Beta strandi29 – 31Combined sources3
Beta strandi40 – 44Combined sources5
Beta strandi50 – 58Combined sources9
Beta strandi61 – 72Combined sources12
Beta strandi76 – 78Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi83 – 90Combined sources8
Turni92 – 94Combined sources3
Beta strandi100 – 102Combined sources3
Helixi105 – 120Combined sources16
Helixi126 – 129Combined sources4
Beta strandi130 – 132Combined sources3
Turni133 – 135Combined sources3
Beta strandi136 – 148Combined sources13
Helixi153 – 166Combined sources14
Beta strandi169 – 174Combined sources6
Beta strandi181 – 190Combined sources10
Beta strandi193 – 195Combined sources3
Beta strandi198 – 205Combined sources8
Beta strandi208 – 212Combined sources5
Helixi215 – 220Combined sources6
Beta strandi222 – 229Combined sources8
Turni231 – 233Combined sources3
Beta strandi235 – 244Combined sources10
Helixi248 – 273Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BR2X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C37X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C38X-ray3.10A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C39X-ray3.30A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2JE6X-ray1.60A1-275[»]
2JEAX-ray2.33A1-275[»]
2JEBX-ray2.40A1-275[»]
3L7ZX-ray2.41A/D/G1-275[»]
4BA1X-ray1.80A1-275[»]
4BA2X-ray2.50A1-275[»]
ProteinModelPortaliQ9UXC0.
SMRiQ9UXC0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UXC0.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family. Rrp42 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01574. Archaea.
COG2123. LUCA.
HOGENOMiHOG000229504.
InParanoidiQ9UXC0.
KOiK12589.
OMAiKKDYIYN.

Family and domain databases

CDDicd11365. RNase_PH_archRRP42. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00622. Exosome_Rrp42. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR020869. Rrp42_archaea.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
SSF55666. SSF55666. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UXC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTPSNQNI IPIIKKESIV SLFEKGIRQD GRKLTDYRPL SITLDYAKKA
60 70 80 90 100
DGSALVKLGT TMVLAGTKLE IDKPYEDTPN QGNLIVNVEL LPLAYETFEP
110 120 130 140 150
GPPDENAIEL ARVVDRSLRD SKALDLTKLV IEPGKSVWTV WLDVYVLDYG
160 170 180 190 200
GNVLDACTLA SVAALYNTKV YKVEQHSNGI SVNKNEVVGK LPLNYPVVTI
210 220 230 240 250
SVAKVDKYLV VDPDLDEESI MDAKISFSYT PDLKIVGIQK SGKGSMSLQD
260 270
IDQAENTARS TAVKLLEELK KHLGI
Length:275
Mass (Da):30,194
Last modified:May 1, 2000 - v1
Checksum:i4188C9D6928A144C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57571.1.
AE006641 Genomic DNA. Translation: AAK41030.1.
PIRiG90221.
RefSeqiWP_009991305.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41030; AAK41030; SSO0732.
GeneIDi27427054.
KEGGisso:SSO0732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57571.1.
AE006641 Genomic DNA. Translation: AAK41030.1.
PIRiG90221.
RefSeqiWP_009991305.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BR2X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C37X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C38X-ray3.10A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C39X-ray3.30A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2JE6X-ray1.60A1-275[»]
2JEAX-ray2.33A1-275[»]
2JEBX-ray2.40A1-275[»]
3L7ZX-ray2.41A/D/G1-275[»]
4BA1X-ray1.80A1-275[»]
4BA2X-ray2.50A1-275[»]
ProteinModelPortaliQ9UXC0.
SMRiQ9UXC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60492N.
STRINGi273057.SSO0732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41030; AAK41030; SSO0732.
GeneIDi27427054.
KEGGisso:SSO0732.

Phylogenomic databases

eggNOGiarCOG01574. Archaea.
COG2123. LUCA.
HOGENOMiHOG000229504.
InParanoidiQ9UXC0.
KOiK12589.
OMAiKKDYIYN.

Miscellaneous databases

EvolutionaryTraceiQ9UXC0.

Family and domain databases

CDDicd11365. RNase_PH_archRRP42. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00622. Exosome_Rrp42. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR020869. Rrp42_archaea.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
SSF55666. SSF55666. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRRP42_SULSO
AccessioniPrimary (citable) accession number: Q9UXC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.