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Protein

Argininosuccinate lyase

Gene

argH

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:SSO0639
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001378701 – 444Argininosuccinate lyaseAdd BLAST444

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0639.

Structurei

3D structure databases

ProteinModelPortaliQ9UX32.
SMRiQ9UX32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01748. Archaea.
COG0165. LUCA.
HOGENOMiHOG000242744.
InParanoidiQ9UX32.
KOiK01755.
OMAiSIMPHKK.
OrthoDBiPOG093Z09KV.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 2 hits.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UX32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYRKWGSEK DEVVNYTSSV DSDREIIEEV KLTMKAHVIS LYLTGYLGKE
60 70 80 90 100
TARKILVALN EFKEIGQGYE DIHEALEDFL IKKVGEDAGW IGLGRSRNDH
110 120 130 140 150
VATALRLRLR NKLIELLTDI NSLRKILLDK AKEHITTIFP SYTHLQLAQP
160 170 180 190 200
TTFAHYLTYI EEELASRWEI IFSTLKQVNK SPLGSGAIVG TNVKIDREKE
210 220 230 240 250
AELLGFDSII YNTLSATSSR ADILSTISEL TVLMVVLSRI AEDLIFFSSN
260 270 280 290 300
KLIKLPDSHV STSSLMPQKR NPVTMEILRA KAAESIGMLT SLLSIYKGLP
310 320 330 340 350
TGYNLDLQEM NKYYWLVINY TKSSIGVLSS LFSQIQVNKI NIDESSLATD
360 370 380 390 400
DAELLSISKK VPYRSTYFEI AKKVREGSYK STLKIEDSIN MKAVIGSPNF
410 420 430 440
DLMANLIKIR ETKLKEDEKE IEEYKLKIIS KLGELQVIEN EIGE
Length:444
Mass (Da):50,263
Last modified:April 23, 2003 - v2
Checksum:i817B75F74C3C60CE
GO

Sequence cautioni

The sequence AAK40947 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB57662 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57662.1. Different initiation.
AE006641 Genomic DNA. Translation: AAK40947.1. Different initiation.
PIRiD90211.
RefSeqiWP_014511588.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40947; AAK40947; SSO0639.
GeneIDi27426941.
KEGGisso:SSO0639.
PATRICifig|273057.12.peg.644.

Similar proteinsi

Entry informationi

Entry nameiARLY_SULSO
AccessioniPrimary (citable) accession number: Q9UX32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: February 28, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome