Argininosuccinate synthase - Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

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Q9UX31 (ASSY_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 77. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Argininosuccinate synthase
EC=6.3.4.5

Alternative name(s):
Citrulline--aspartate ligase

Gene names

Name:	argG
Ordered Locus Names:	SSO0638

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus ›

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00005
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00005.
Sequence similarities	Belongs to the argininosuccinate synthase family. Type 1 subfamily.
Sequence caution	The sequence AAK40946.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB57663.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP argininosuccinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 391

391

Argininosuccinate synthase HAMAP-Rule MF_00005

PRO_0000148686

Regions

Nucleotide binding

6 – 14

ATP By similarity

Sites

Binding site

Citrulline By similarity

Binding site

114

ATP; via amide nitrogen By similarity

Binding site

116

Aspartate By similarity

Binding site

120

Aspartate By similarity

Binding site

120

Citrulline By similarity

Binding site

121

Aspartate By similarity

Binding site

124

Citrulline By similarity

Binding site

171

Citrulline By similarity

Binding site

180

Citrulline By similarity

Binding site

253

Citrulline By similarity

Binding site

265

Citrulline By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UX31 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 58565E5F25A4F5FC
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FASTA

391

44,487

        10         20         30         40         50         60 
MKIVLAYSGG LDTTVSIRWL KETFKAEIIT VTVDVGQKDD FKKIEERAYI AGASKHYTID 

        70         80         90        100        110        120 
AVRQFANNYI AYAIKLNGLY EGVYPLSTAL ARPLIAEKVV EVAKKEGAEA VAHGSTSKGN 

       130        140        150        160        170        180 
DQVRFDLAVK ALYPDVKIIA PARIWNMTRE DEIKYAKEKG IPIKVESDKY SIDENLWGRS 

       190        200        210        220        230        240 
IEGDIISDPS LEVPEDAFEW TKQIYNKKEI VSIEFSNGVP TAVNGEKMEL NKLVDFLNLK 

       250        260        270        280        290        300 
FGSHGFGRVE HIENRVVGFK SREVYEVPAA LGLIYAHIDL EKTIYTPMEL RFKRHIDQLW 

       310        320        330        340        350        360 
SDLVYQGLWF EPLRETLHKV ADEMNKWISG EAKVEVSNGS FRIVGRESEY SPYSEKIASY 

       370        380        390 
NKGWYPSDEM ARGFIEIWGM HSLIARRVRG L

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References

[1]

"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2."
Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N.

Sensen C.W.
Genome 43:116-136(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

[2]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.

Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18930 Genomic DNA. Translation: CAB57663.1. Different initiation. AE006641 Genomic DNA. Translation: AAK40946.1. Different initiation.
PIR	C90211.
RefSeq	NP_342156.1. NC_002754.1.
3D structure databases
ProteinModelPortal	Q9UX31.
ModBase	Search...
Protein-protein interaction databases
STRING	273057.SSO0638.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK40946; AAK40946; SSO0638.
GeneID	1454913.
KEGG	sso:SSO0638.
Phylogenomic databases
eggNOG	COG0137.
HOGENOM	HOG000230093.
KO	K01940.
OMA	NDQFRFE.
ProtClustDB	PRK00509.
Enzyme and pathway databases
BioCyc	SSOL273057:GCH2-608-MONOMER.
UniPathway	UPA00068; UER00113.
Family and domain databases
Gene3D	3.40.50.620. 1 hit. 3.90.1260.10. 1 hit.
HAMAP	MF_00005. Arg_succ_synth_type1.
InterPro	IPR001518. Arginosuc_synth. IPR018223. Arginosuc_synth_CS. IPR023434. Arginosuc_synth_type_1_subfam. IPR024074. AS_cat/multimer_dom_body. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR11587. PTHR11587. 1 hit.
Pfam	PF00764. Arginosuc_synth. 1 hit. [Graphical view]
TIGRFAMs	TIGR00032. argG. 1 hit.
PROSITE	PS00564. ARGININOSUCCIN_SYN_1. 1 hit. PS00565. ARGININOSUCCIN_SYN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASSY_SULSO

Accession

Primary (citable) accession number: Q9UX31

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	September 27, 2005
Last modified:	May 29, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents