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Q9UX31 (ASSY_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:SSO0638
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Sequence caution

The sequence AAK40946.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAB57663.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000148686

Regions

Nucleotide binding6 – 149ATP By similarity

Sites

Binding site841Citrulline By similarity
Binding site1141ATP; via amide nitrogen By similarity
Binding site1161Aspartate By similarity
Binding site1201Aspartate By similarity
Binding site1201Citrulline By similarity
Binding site1211Aspartate By similarity
Binding site1241Citrulline By similarity
Binding site1711Citrulline By similarity
Binding site1801Citrulline By similarity
Binding site2531Citrulline By similarity
Binding site2651Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UX31 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 58565E5F25A4F5FC

FASTA39144,487
        10         20         30         40         50         60 
MKIVLAYSGG LDTTVSIRWL KETFKAEIIT VTVDVGQKDD FKKIEERAYI AGASKHYTID 

        70         80         90        100        110        120 
AVRQFANNYI AYAIKLNGLY EGVYPLSTAL ARPLIAEKVV EVAKKEGAEA VAHGSTSKGN 

       130        140        150        160        170        180 
DQVRFDLAVK ALYPDVKIIA PARIWNMTRE DEIKYAKEKG IPIKVESDKY SIDENLWGRS 

       190        200        210        220        230        240 
IEGDIISDPS LEVPEDAFEW TKQIYNKKEI VSIEFSNGVP TAVNGEKMEL NKLVDFLNLK 

       250        260        270        280        290        300 
FGSHGFGRVE HIENRVVGFK SREVYEVPAA LGLIYAHIDL EKTIYTPMEL RFKRHIDQLW 

       310        320        330        340        350        360 
SDLVYQGLWF EPLRETLHKV ADEMNKWISG EAKVEVSNGS FRIVGRESEY SPYSEKIASY 

       370        380        390 
NKGWYPSDEM ARGFIEIWGM HSLIARRVRG L 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y18930 Genomic DNA. Translation: CAB57663.1. Different initiation.
AE006641 Genomic DNA. Translation: AAK40946.1. Different initiation.
PIRC90211.
RefSeqNP_342156.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ9UX31.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0638.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40946; AAK40946; SSO0638.
GeneID1454913.
KEGGsso:SSO0638.

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMARFESTIR.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-608-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_SULSO
AccessionPrimary (citable) accession number: Q9UX31
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways