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Q9UX31

- ASSY_SULSO

UniProt

Q9UX31 - ASSY_SULSO

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841CitrullineUniRule annotation
Binding sitei114 – 1141ATP; via amide nitrogenUniRule annotation
Binding sitei116 – 1161AspartateUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei120 – 1201CitrullineUniRule annotation
Binding sitei121 – 1211AspartateUniRule annotation
Binding sitei124 – 1241CitrullineUniRule annotation
Binding sitei171 – 1711CitrullineUniRule annotation
Binding sitei180 – 1801CitrullineUniRule annotation
Binding sitei253 – 2531CitrullineUniRule annotation
Binding sitei265 – 2651CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 149ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-608-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:SSO0638
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Argininosuccinate synthasePRO_0000148686Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0638.

Structurei

3D structure databases

ProteinModelPortaliQ9UX31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
InParanoidiQ9UX31.
KOiK01940.
OMAiRFESTIR.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UX31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIVLAYSGG LDTTVSIRWL KETFKAEIIT VTVDVGQKDD FKKIEERAYI
60 70 80 90 100
AGASKHYTID AVRQFANNYI AYAIKLNGLY EGVYPLSTAL ARPLIAEKVV
110 120 130 140 150
EVAKKEGAEA VAHGSTSKGN DQVRFDLAVK ALYPDVKIIA PARIWNMTRE
160 170 180 190 200
DEIKYAKEKG IPIKVESDKY SIDENLWGRS IEGDIISDPS LEVPEDAFEW
210 220 230 240 250
TKQIYNKKEI VSIEFSNGVP TAVNGEKMEL NKLVDFLNLK FGSHGFGRVE
260 270 280 290 300
HIENRVVGFK SREVYEVPAA LGLIYAHIDL EKTIYTPMEL RFKRHIDQLW
310 320 330 340 350
SDLVYQGLWF EPLRETLHKV ADEMNKWISG EAKVEVSNGS FRIVGRESEY
360 370 380 390
SPYSEKIASY NKGWYPSDEM ARGFIEIWGM HSLIARRVRG L
Length:391
Mass (Da):44,487
Last modified:September 27, 2005 - v2
Checksum:i58565E5F25A4F5FC
GO

Sequence cautioni

The sequence AAK40946.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB57663.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57663.1. Different initiation.
AE006641 Genomic DNA. Translation: AAK40946.1. Different initiation.
PIRiC90211.
RefSeqiNP_342156.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40946; AAK40946; SSO0638.
GeneIDi1454913.
KEGGisso:SSO0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57663.1 . Different initiation.
AE006641 Genomic DNA. Translation: AAK40946.1 . Different initiation.
PIRi C90211.
RefSeqi NP_342156.1. NC_002754.1.

3D structure databases

ProteinModelPortali Q9UX31.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40946 ; AAK40946 ; SSO0638 .
GeneIDi 1454913.
KEGGi sso:SSO0638.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
InParanoidi Q9UX31.
KOi K01940.
OMAi RFESTIR.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SSOL273057:GCH2-608-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiASSY_SULSO
AccessioniPrimary (citable) accession number: Q9UX31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3