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Q9UX29

- PUR5_SULSO

UniProt

Q9UX29 - PUR5_SULSO

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-606-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:SSO0636
ORF Names:C08_014
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148289Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0636.

Structurei

3D structure databases

ProteinModelPortaliQ9UX29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
InParanoidiQ9UX29.
KOiK01933.
OMAiMEMINSE.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UX29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSEEYKKAG VDLEKLRNYH NMISQIISST YKNTIIGAGH YSGVIKIGSL
60 70 80 90 100
NIAMHTDGVG TKTFLALQTR IIKPVGIDCV AMNVNDLICV GAKPVALVDY
110 120 130 140 150
IALERPMDNV VNEIIDGIVQ GAKEADVEVI GGETAIMPDV IRGFDLSCTA
160 170 180 190 200
IGVVDKLKTG AEIRPGDYVL GLESSGIHAN GYSLVRKLIE EGKLSLDEYK
210 220 230 240 250
NELLKPTKIY VKPILEVMNM IKGAAHVTGG AFSKLKRLTS YKIVLNMPDP
260 270 280 290 300
PQIFKTIEKA GVAHEEMYKV FNMGIGIVLF VSEELMKEVK TKLEGYGTVY
310 320
ELGRVYNGNG ITIKTYKNEI LRL
Length:323
Mass (Da):35,400
Last modified:May 1, 2000 - v1
Checksum:i17202798E4C5A401
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18930 Genomic DNA. Translation: CAB57665.1.
AE006641 Genomic DNA. Translation: AAK40944.1.
PIRiA99211.
RefSeqiNP_342154.1. NC_002754.1.
WP_009991170.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40944; AAK40944; SSO0636.
GeneIDi1454911.
KEGGisso:SSO0636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18930 Genomic DNA. Translation: CAB57665.1 .
AE006641 Genomic DNA. Translation: AAK40944.1 .
PIRi A99211.
RefSeqi NP_342154.1. NC_002754.1.
WP_009991170.1. NC_002754.1.

3D structure databases

ProteinModelPortali Q9UX29.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40944 ; AAK40944 ; SSO0636 .
GeneIDi 1454911.
KEGGi sso:SSO0636.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
InParanoidi Q9UX29.
KOi K01933.
OMAi MEMINSE.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SSOL273057:GCH2-606-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiPUR5_SULSO
AccessioniPrimary (citable) accession number: Q9UX29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3