Q9UX25 (Q9UX25_SULSF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485

Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485

Gene names

Name:

ORF-c08_018 EMBL CAB57669.1

Organism

Sulfolobus solfataricus EMBL CAB57669.1

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485
Cofactor	Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3 Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485
Sequence similarities	In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Ontologies

Keywords
Biological process	Purine biosynthesis PIRNR PIRNR000485
Ligand	Iron Iron-sulfur PIRSR PIRSR000485-3 Magnesium PIRNR PIRNR000485 Metal-binding
Molecular function	Glycosyltransferase PIRNR PIRNR000485 EMBL CAB57669.1 Transferase
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro purine base biosynthetic process Inferred from electronic annotation. Source: InterPro purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amidophosphoribosyltransferase activity Inferred from electronic annotation. Source: EC iron-sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	8	1	For GATase activity By similarity PIRSR PIRSR000485-1
	Metal binding	230	1	Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
	Metal binding	376	1	Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
	Metal binding	425	1	Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
	Metal binding	428	1	Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

	Sequence		Length	Mass (Da)
	Q9UX25 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5B0FACBEC8135B60	FASTA	450	50,494
	10 20 30 40 50 60 MDSIRDKCGV FAVSSPKEVN IQLVVEGIRL LQHRGQESAG IAYAENGEIL TIKGSGLVDE 70 80 90 100 110 120 VFKENLNKFI KNGIGHVRYS TSGKSSIEEA QPLGDSKIVV AFNGTISNYY QFGSFRVDTE 130 140 150 160 170 180 FIYKFFKQKL AFRSIPDTVK EFMKVVDGGY SVAILLNDEE IVVFRDPKGF HPVVLGFLEG 190 200 210 220 230 240 SLIVSSEDSV IRQLGGSVLK HILPSEMIIM KNGKILYDKV IYEEKNYATC SFEYIYFARP 250 260 270 280 290 300 DSNIDGHSVY LARIRLGELL AEKHPANGDI VVPVPDSSRP IALGFSRKSH IPLEEPLVRT 310 320 330 340 350 360 ISSVRSFIMP TQDKRNEVLE EKFGVVADAV RGKRIVLIDD SIVRGNTMKR IITMLRKAGA 370 380 390 400 410 420 KEIHVRIGSP MIKYPCYMGI DFPKREELIA HNKSEKEIGN ELNADSIEFL SVEEMLQGIG 430 440 450 RRDLCNACFS GIYPLKFNYN STELERIFGK

References

[1]

"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2." Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N. , Peng X., Penny S.L., She Q., St Jean A., van der Oost J., Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W. Genome 43:116-136(2000) [PubMed: 10701121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: P2 EMBL CAB57669.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18930 Genomic DNA. Translation: CAB57669.1.
PIR	F90210.
RefSeq	NP_342151.1. NC_002754.1.
3D structure databases
HSSP	HSSP built from PDB template 1AO0 based on UniProtKB P00497.
ProteinModelPortal	Q9UX25.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1454908.
NMPDR	fig|273057.1.peg.574.
Phylogenomic databases
HOGENOM	HBG392416.
OMA	DIAQMIC.
PhylomeDB	Q9UX25.
ProtClustDB	CLSK802804.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0632-MONOMER.
Family and domain databases
InterPro	IPR005854. Amd_phspho_trans. IPR000583. GATase_2. IPR017932. GATase_II. IPR000836. PRibTrfase. [Graphical view]
PANTHER	PTHR11907. Amd_phspho_trans. 1 hit.
Pfam	PF00310. GATase_2. 1 hit. PF00156. Pribosyltran. 1 hit. [Graphical view]
PIRSF	PIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMs	TIGR01134. PurF. 1 hit.
PROSITE	PS51278. GATASE_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9UX25_SULSF

Accession

Primary (citable) accession number: Q9UX25

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)