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Q9UX24 (PURL_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2
EC=6.3.5.3
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II
Short name=FGAM synthase II
Gene names
Name:purL
Ordered Locus Names:SSO0629
ORF Names:C08_019
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL.

Subcellular location

Cytoplasm By similarity HAMAP MF_00420.

Sequence similarities

Belongs to the FGAMS family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
PRO_0000100525

Regions

Nucleotide binding95 – 10612ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q9UX24 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 150777DE8D23E5CA

FASTA70977,089
        10         20         30         40         50         60 
MGINLLPIEM DEIRKRLGRE PNETEWRVID AVWSEHCSYK SSKIFLKSFS IDSPNVIMGI 

        70         80         90        100        110        120 
KDWQDAGAVD IGDGWAVVIK VESHNHPSAI DPFNGAATGV GGIIRDIISK GAKPIALMDM 

       130        140        150        160        170        180 
IRVGNLKIKK NVWLLKNIIA GIAAYGNSIG VPVVGGELSF DDTYNDNPLV DVAAIGIVRK 

       190        200        210        220        230        240 
DKIKPSIVDK AGLKLVLAGL TGVDGLGGAS FASRKLSGED EIGAVQIADP FAGKIILDVT 

       250        260        270        280        290        300 
LEIADKVEAI KDLGGGGLAV AVTEITNGLG ATVDIEKIPL RVKNMNPSDV IISETQERML 

       310        320        330        340        350        360 
YAVEEKNVKE VCEAFEEYEY PCSVIGEITN EPVIKFRYIG KDLVSLPTNV LLNPPRFLWP 

       370        380        390        400        410        420 
IKNTKKNVEE KIVDLPLESA IYTVLTHPDL VSKGWAYSQF DYEVNTSTVV KPGDADSAVV 

       430        440        450        460        470        480 
SLPNGKLLAI KADANPDMCA EDGYECGKGI VAEAYRNLAT VGARGMVAVD HLQFGDPKKA 

       490        500        510        520        530        540 
EVYYTFVEAI RGIGEATRFF NIPIVGGKVS FYNENNQGRP IKPTPLIVMA GLVQDKLLKN 

       550        560        570        580        590        600 
RVEDNLYVVS VGYTRKELGG SLLSKIFKIP SQAPKVRLQE DLLSSEVVID SINEGKITFA 

       610        620        630        640        650        660 
KDVSRGGLAA SLFSILVHGY GVEISTKSIL SDTDNVIENL FSESSGRFIV LTNEPEWIVE 

       670        680        690        700 
KSKSKGIVAS IIGRVNKKTN ILTIDNIDYN LKNIVDNYFN FLEEVMGNG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y18930 Genomic DNA. Translation: CAB57670.1.
AE006641 Genomic DNA. Translation: AAK40940.1.
PIRE90210.
RefSeqNP_342150.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ9UX24.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1454907.
GenomeReviewsGene locus SSO0629 in contig AE006641_GR.
KEGGsso:SSO0629.
NMPDRfig|273057.1.peg.573.

Phylogenomic databases

HOGENOMHBG311214.
OMAYGNSFGV.
ProtClustDBPRK01213.

Enzyme and pathway databases

BioCycSSOL273057:SSO0629-MONOMER.

Family and domain databases

HAMAPMF_00420. PurL_2.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
KOK01952.
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry namePURL_SULSO
AccessionPrimary (citable) accession number: Q9UX24
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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