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Protein

tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase

Gene

taw3

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseUniRule annotation (EC:2.1.1.282UniRule annotation)
Alternative name(s):
tRNA wyosine derivatives biosynthesis protein Taw3UniRule annotation
Gene namesi
Name:taw3UniRule annotation
Ordered Locus Names:SSO0622
ORF Names:C08_028
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001571021 – 209tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseAdd BLAST209

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0622.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 20Combined sources18
Helixi26 – 28Combined sources3
Helixi29 – 37Combined sources9
Beta strandi40 – 48Combined sources9
Beta strandi51 – 59Combined sources9
Beta strandi67 – 74Combined sources8
Helixi78 – 86Combined sources9
Beta strandi90 – 98Combined sources9
Beta strandi101 – 108Combined sources8
Helixi109 – 122Combined sources14
Beta strandi128 – 133Combined sources6
Beta strandi136 – 141Combined sources6
Beta strandi146 – 154Combined sources9
Helixi161 – 189Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TLJX-ray2.80A/B1-209[»]
ProteinModelPortaliQ9UX16.
SMRiQ9UX16.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UX16.

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
HOGENOMiHOG000222308.
InParanoidiQ9UX16.
KOiK15450.
OMAiTMSSCSG.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UX16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVWEELREK ALNKIYHDKE IGYLDPDILG FLLAFYRNRN DVYTQSSCSG
60 70 80 90 100
RITIVDAEMP WDRKNSTIIF KNHLRITEQD LEDVLSKNQV RRLWLIVQGP
110 120 130 140 150
IIHIYAKNIE TGWDILKIAR EAGFKHSGIL ATNQKGVLVE LRTGIRMVHL
160 170 180 190 200
LRESNTERVD KDKIKTLVNV CNEVLARGKQ KMNLLKDLLS SSSNNSMELG

KNSKLKTPI
Length:209
Mass (Da):24,115
Last modified:May 1, 2000 - v1
Checksum:iEA94C8B46E1FB88B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57678.1.
AE006641 Genomic DNA. Translation: AAK40933.1.
PIRiF90209.
RefSeqiWP_009991156.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40933; AAK40933; SSO0622.
GeneIDi27426926.
KEGGisso:SSO0622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA. Translation: CAB57678.1.
AE006641 Genomic DNA. Translation: AAK40933.1.
PIRiF90209.
RefSeqiWP_009991156.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TLJX-ray2.80A/B1-209[»]
ProteinModelPortaliQ9UX16.
SMRiQ9UX16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40933; AAK40933; SSO0622.
GeneIDi27426926.
KEGGisso:SSO0622.

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
HOGENOMiHOG000222308.
InParanoidiQ9UX16.
KOiK15450.
OMAiTMSSCSG.

Miscellaneous databases

EvolutionaryTraceiQ9UX16.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTYW3_SULSO
AccessioniPrimary (citable) accession number: Q9UX16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.